HOXA9, homeobox A9, 3205

N. diseases: 147; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.060 Biomarker group BEFREE However, mutant IDH1 greatly accelerated onset of myeloproliferative disease-like myeloid leukemia in mice in cooperation with HoxA9 with a mean latency of 83 days compared with cells expressing HoxA9 and wild-type IDH1 or a control vector (167 and 210 days, respectively, P = .001). 23954893 2013
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.060 GeneticVariation group BEFREE The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice. 22932805 2012
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.060 Biomarker group BEFREE NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis. 21810091 2011
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.060 GeneticVariation group BEFREE The NUP98-HOXA9 fusion gene with t(7;11)(p15;p15) was identified and revealed to be essential for leukemogenesis and myeloproliferative disease. 19338047 2009
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.060 AlteredExpression group BEFREE Expression of NUP98-HOXA9 in murine bone marrow resulted in a myeloproliferative disease progressing to AML by 7-8 months. 17442773 2007
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.060 AlteredExpression group BEFREE Mice transplanted with bone marrow cells expressing NUP98-HOXA9 through retroviral transduction acquire a myeloproliferative disease (MPD) and eventually succumb to acute myeloid leukemia (AML). 11157742 2001