|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The aim of the present study was to evaluate the correlation between HOXB9 expression, prognosis and clinicopathologic factors in patients with gastric cancer, and to assess the contribution of HOXB9 expression to tumor cell lymphangiogenesis <i>in vitro</i>.
|
30867739 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, AcK27-HOXB9 underlies the tumour suppressive role of HOXB9.
|
29654889 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, patients affected by an HOXB9-negative tumor had a significantly longer PFS compared with those with an HOXB9-positive tumor if treated with a first-line regimen containing bevacizumab (18.0 months vs. 10.4 months; HR 2.037; 95% confidence interval, 1.006-4.125; <i>P</i> = 0.048).<b>Conclusions:</b> These findings integrate the complexity of numerous mechanisms of anti-VEGF resistance into the single transcription factor HOXB9.
|
28298545 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HOXB7 and HOXB9 are members of the class I homeobox-containing genes important for normal embryogenesis and that are dysregulated in several human neoplasms.
|
26991799 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Functionally, in contrast to the wild type HOXB9, AcK27-HOXB9 decreased its capacity in promoting lung cancer cell migration and tumor growth in mice.
|
27613418 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Correlation was shown between PD-L1 and tumor size and lymph node metastasis, HOXB9 and tumor size, BLNK and perineural invasion, and between ZNF813 and perineural invasion.
|
26041877 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HOXB9 induced angiogenesis and tumor proliferation in vitro, which resulted in high tumorigenicity in vivo and poor overall survival.
|
24885802 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Homeobox B9 (HOXB9), a member of the homeobox gene family, is overexpressed in breast cancer and promotes tumor progression and metastasis by stimulating epithelial-to-mesenchymal transition and angiogenesis within the tumor microenvironment.
|
25136922 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results provide the first evidence that HOXB9 is a critical regulator of tumor growth factor in HCC.
|
24462859 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overexpression of HOXB9 inhibited colon adenocarcinoma cell growth, migration, invasion in vitro and tumour growth, liver as well as lung metastases in nude mice; whereas silencing HOXB9 promoted these functions.
|
25025961 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HOXB9 and PHF20L1 are members of gene families that are fused in other neoplasms.
|
23260012 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, we demonstrated that HOXB9 is a critical regulator of tumor growth factors and is associated with tumorigenesis.
|
22863320 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Measuring the expression of HOX genes HOXB1-HOXB9 in primary tumors revealed that a subset of tumors show highly elevated expression indicating that these might be potentially very sensitive to killing by HXR9.
|
23053648 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, HOXB9 promotes the formation of large, well-vascularized tumors that metastasize to the lung.
|
20080567 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Independent variations of mRNA expression of HER-2/neu and prostate-specific antigen were observed in hormone-independent tumors whereas HOXB9 gene expression was constant.
|
11485933 |
2001 |