|
Congenital kyphoscoliosis
|
0.200 |
Biomarker
|
disease |
RGD |
Abnormalities of vertebral formation and Hox expression in congenital kyphoscoliotic rats.
|
18327665 |
2008 |
|
Kyphoscoliosis deformity of spine
|
0.200 |
Biomarker
|
disease |
RGD |
Abnormalities of vertebral formation and Hox expression in congenital kyphoscoliotic rats.
|
18327665 |
2008 |
|
Acquired Kyphoscoliosis
|
0.200 |
Biomarker
|
disease |
RGD |
Abnormalities of vertebral formation and Hox expression in congenital kyphoscoliotic rats.
|
18327665 |
2008 |
|
Tumor Cell Invasion
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Silencing HOXC10 suppressed proliferation, migration, and invasion in vitro, and inhibited tumor growth and induced apoptosis in vivo.
|
31552684 |
2020 |
|
Tumor Cell Invasion
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Cell proliferation, migration and invasion were assessed using the Cell Counting Kit-8 (CCK-8) and colony formation assay, wound healing, Transwell assay, respectively in GBM U87 cell after HOXC10 knockdown.
|
29768063 |
2019 |
|
Tumor Cell Invasion
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Bioinformatics and cellular study further confirmed that HOXC10 may promote invasion and migration of OSCC cells by regulating the WNT/epithelial-mesenchymal transition (EMT) signaling pathway.
|
31528218 |
2019 |
|
Tumor Cell Invasion
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
HOXC10 promotes proliferation and invasion and induces immunosuppressive gene expression in glioma.
|
29676849 |
2018 |
|
Tumor Cell Invasion
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
HOXC10 may promote invasion and migration of GC by regulating ATM/NF-κB signaling pathway.
|
29753747 |
2018 |
|
Tumor Cell Invasion
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
In addition, knockdown of HOXC10 reduced GC-9811P cell migration and invasion, similar to the phenotype observed with miR-136 restoration in these cells, indicating that HOXC10 functions as a metastasis promoter in gastric cancer peritoneal metastasis.
|
28656883 |
2017 |
|
Tumor Cell Invasion
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
HOXC10 knockdown by shRNA conferred cell cycle blocking and inhibition of migration and invasion.
|
26279264 |
2015 |
|
Tumor Cell Invasion
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion.
|
17974957 |
2007 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
HOXC10 may play an important role in PD gastric carcinoma cell proliferation, cell cycle, migration, invasion, and metastasis through upregulating proinflammatory cytokines via NF-κB pathway, suggesting HOXC10 may serve as a novel therapeutic target for PD gastric cancer.
|
31552684 |
2020 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
HOXC10 promoted cell proliferation and metastasis in two gastric cancer cell lines (AGS and MKN74).
|
31115563 |
2019 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
These findings suggest that HOXC10 plays a pivotal role in the metastasis of OSCC and highlight its usefulness as a potential prognostic marker or therapeutic target in human OSCC.
|
31528218 |
2019 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
In the 73 GC patients tissue microarrays (TMA) tested, HOXC10 expression was closely related with tumor-node-metastasis (TNM) stage, lymph node metastasis, and distant metastasis.
|
29753747 |
2018 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, our results showed that ectopic expression of HOXC10 could reverse inhibition of metastasis by overexpressed miR-136 in GC-9811P cells.
|
28656883 |
2017 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
<b>Conclusion:</b> These findings suggest that HOXC10 plays a pivotal role in the metastasis of human lung cancer and highlight its usefulness as a potential prognostic marker or therapeutic target in human lung adenocarcinoma.
|
28824453 |
2017 |
|
Neoplasm Metastasis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
We found that HOXC10 is overexpressed in primary carcinomas of the breast, and even more significantly in distant metastasis arising after failed chemotherapy.
|
27302171 |
2016 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Blocking HOXC10 function, therefore, presents a promising new strategy to overcome chemotherapy resistance in breast cancer.
|
27302171 |
2016 |
|
Breast Carcinoma
|
0.040 |
PosttranslationalModification
|
disease |
BEFREE |
Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer.
|
24670685 |
2014 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We found that HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen (17β-estradiol, E(2)).
|
22143955 |
2012 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We validated significant overexpression of transcripts for HOXC10 (P=0.001), TPD52L1 (P=0.007), ZFP36L1 (P=0.011), PLINP1 (P=0.013), DCTN3 (P=0.025), DEK (P=0.031), and CSNK1D (P=0.04) in lymph node (+) breast carcinomas.
|
17855657 |
2007 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
As a master regulator of embryonic morphogenesis, homeodomain-containing gene 10 (HOXC10) has been found to promote progression of human cancers and indicate poor survival outcome.
|
31528218 |
2019 |
|
Malignant neoplasm of stomach
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
HOXC10 expression was determined in gastric cancer tissues acquired from 300 patients with gastric cancer.
|
30673899 |
2019 |
|
Malignant neoplasm of stomach
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
HOXC10 overexpression promotes cell proliferation and migration in gastric cancer.
|
31115563 |
2019 |