HOXD1, homeobox D1, 3231

N. diseases: 28; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.010 AlteredExpression disease BEFREE However, a significant induction of HOXC6, HOXD1, and HOXD8 expression is seen in the RA-treated NB cell lines, albeit with different patterns and degree of up-regulation. db-cAMP treatment also induced HOXC6 and HOXD8 expression in two of the three NB cell lines analyzed. 7501971 1996
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.010 AlteredExpression disease BEFREE However, a significant induction of HOXC6, HOXD1, and HOXD8 expression is seen in the RA-treated NB cell lines, albeit with different patterns and degree of up-regulation. db-cAMP treatment also induced HOXC6 and HOXD8 expression in two of the three NB cell lines analyzed. 7501971 1996
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.010 AlteredExpression disease BEFREE However, a significant induction of HOXC6, HOXD1, and HOXD8 expression is seen in the RA-treated NB cell lines, albeit with different patterns and degree of up-regulation. db-cAMP treatment also induced HOXC6 and HOXD8 expression in two of the three NB cell lines analyzed. 7501971 1996
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.300 Biomarker disease CTD_human Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. 17892325 2007
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.300 Biomarker group CTD_human Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. 17892325 2007
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.310 Biomarker disease CTD_human Analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development. 20852632 2010
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.310 Biomarker disease CTD_human Analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development. 20852632 2010
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0030193
Disease: Pain
Pain 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0234238
Disease: Ache
Ache 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0234254
Disease: Radiating pain
Radiating pain 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0458247
Disease: Allodynia
Allodynia 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0458257
Disease: Pain, Splitting
Pain, Splitting 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0458259
Disease: Pain, Crushing
Pain, Crushing 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0751211
Disease: Hyperalgesia, Primary
Hyperalgesia, Primary 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0751212
Disease: Hyperalgesia, Secondary
Hyperalgesia, Secondary 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0751213
Disease: Tactile Allodynia
Tactile Allodynia 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0751407
Disease: Pain, Migratory
Pain, Migratory 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0751408
Disease: Suffering, Physical
Suffering, Physical 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 Biomarker disease BEFREE Within that category, we have identified the combination of NDRG2 and HOXD1 as the most sensitive (94%) and specific (90%) gene combination for detection of BC; (2) genes that show stage dependent methylation frequency pattern, which are candidates to help delineate BC prognostic signatures. 22647880 2012
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 Biomarker disease BEFREE Within that category, we have identified the combination of NDRG2 and HOXD1 as the most sensitive (94%) and specific (90%) gene combination for detection of BC; (2) genes that show stage dependent methylation frequency pattern, which are candidates to help delineate BC prognostic signatures. 22647880 2012
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.310 GeneticVariation disease BEFREE We think that the non-coding rs2072590 variant may contribute to OC susceptibility by regulating the gene expression of HOXD1 and HOXD3. 29262571 2017