HOXD4, homeobox D4, 3233

N. diseases: 15; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.010 GeneticVariation disease BEFREE The p.Glu81Val mutation of HOXD4 thus results in a partial loss-of-function, which might be involved in childhood ALL. 15776434 2005
CUI: C0751606
Disease: Adult Acute Lymphocytic Leukemia
Adult Acute Lymphocytic Leukemia 		0.010 GeneticVariation disease BEFREE The p.Glu81Val mutation of HOXD4 thus results in a partial loss-of-function, which might be involved in childhood ALL. 15776434 2005
CUI: C0078981
Disease: Arachnoid Cysts
Arachnoid Cysts 		0.010 GeneticVariation disease BEFREE Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst. 26545093 2015
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 Biomarker phenotype BEFREE As a component of HOX clusters, HOXD4 plays a controversial role in the tumorigenesis of central nervous system. 29383189 2017
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.310 GeneticVariation disease BEFREE The p.Glu81Val mutation of HOXD4 thus results in a partial loss-of-function, which might be involved in childhood ALL. 15776434 2005
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.310 Biomarker disease CTD_human The p.Glu81Val mutation of HOXD4 thus results in a partial loss-of-function, which might be involved in childhood ALL. 15776434 2005
CUI: C0278701
Disease: Gastric Adenocarcinoma
Gastric Adenocarcinoma 		0.010 Biomarker disease BEFREE The role of HOXD4 in human gastric adenocarcinoma has not been elucidated. 30588951 2019
CUI: C0017638
Disease: Glioma
Glioma 		0.010 AlteredExpression disease BEFREE Clinicopathological analysis of HOXD4 expression in 453 glioma patients was performed in the current study. 29383189 2017
CUI: C0023453
Disease: L2 Acute Lymphoblastic Leukemia
L2 Acute Lymphoblastic Leukemia 		0.300 Biomarker disease CTD_human Mutation analysis of the HOX paralogous 4-13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function. 15776434 2005
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 GeneticVariation group BEFREE Mutation analysis of the HOX paralogous 4-13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function. 15776434 2005
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE Cellular results revealed that HOXD4 can promote tumor cell proliferation by upregulating c-Myc and cyclin D1. 30588951 2019
CUI: C1961102
Disease: Precursor Cell Lymphoblastic Leukemia Lymphoma
Precursor Cell Lymphoblastic Leukemia Lymphoma 		0.300 Biomarker disease CTD_human Mutation analysis of the HOX paralogous 4-13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function. 15776434 2005
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.010 AlteredExpression disease BEFREE Low levels of HOXD4 and HOXD9 induction were observed in two and one RA-treated NB cell line, respectively. 7501971 1996
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.010 AlteredExpression disease BEFREE Low levels of HOXD4 and HOXD9 induction were observed in two and one RA-treated NB cell line, respectively. 7501971 1996
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.010 AlteredExpression disease BEFREE High expression of HOXD4 was significantly associated with larger tumor size (P = 0.008), advanced tumor invasion depth (P = 0.014), and positive lymph node metastasis (P < 0.001). 30588951 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.010 Biomarker phenotype BEFREE The effects and mechanisms of HOXD4 on cell proliferation, migration and invasion were explored through cellular experiments. 30588951 2019