|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In addition, loss of heterozygosity (LOH) close to the adenomatous polyposis coli (APC) gene (5q21) was examined in these tumors.
|
20091866 |
2010 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The existence of an unknown tumor-suppressor gene on 5q for esophageal carcinoma other than the APC gene has been suggested.
|
8536888 |
1996 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
For none of these genes did promoter methylation exceed 15% of tumour samples, and, for some genes (FHIT and APC), no methylation was found at all.
|
18211945 |
2008 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
These genetic alterations include mutations in the K-ras oncogene and mutation in the one allele coupled with loss of the second allele for the tumor suppressor genes APC, DCC, and p53.
|
8960890 |
1996 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Among oncogenes, germline missense single nucleotide variants were observed in the TP53 and APC genes in both the tumor and normal tissue.
|
28099595 |
2017 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
APC is a tumour-suppressor gene, and somatic loss occurs in tumours.
|
9731533 |
1998 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Since the alteration of the APC gene occurs early in most colorectal tumors, the detection of APC mutations in fecal tumor DNA by HD-PCR may be a powerful tool in non-invasive cancer diagnostics.
|
9450908 |
1998 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The adenomatous polyposis coli (APC) gene, responsible for familial adenomatous polyposis, is also associated with development of sporadic tumors in digestive system as colon, stomach, or pancreas.
|
8242071 |
1993 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We sought to identify molecular aberrations in "wild-type" tumors (those without CTNNB1 or APC alteration) and to determine their prognostic relevance.
|
26171757 |
2015 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Furthermore, the APC gene met two criteria of importance for tumour initiation.
|
1528264 |
1992 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In this study, we examined beta-catenin and APC mutations in 22 HCCs associated with HCV infection, using single-strand conformation polymorphism (SSCP) followed by direct DNA sequencing. beta-Catenin mutations were found in nine (41%) cases, but no APC mutations were found. beta-Catenin immunohistochemistry revealed nuclear accumulation of beta-catenin protein in all nine tumors with a beta-catenin mutation and two additional tumors without a mutation.
|
10595907 |
1999 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Introducing the CD4-TLR4 transgene into APC(Min/+) mice (CD4-TLR4-APC(Min/+)), a model of colorectal carcinoma, resulted in a dramatic drop in tumor load as compared with control APC(Min/+) mice.
|
23318418 |
2014 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The quantitative DNA methylation analysis of the candidate genes showed higher methylation proportion in the primary tumor tissue than that of the matched normal tissue and the differences were significant for the APC, BIN1, BMP6, BRCA1, CST6, ESR-b, P16, PTEN and TIMP3 promoter regions (P<0.05).
|
22695536 |
2012 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
This suggests that, similar to in vivo priming, peptide-pulsed APC are capable of stimulating a T-cell response in vitro expressing a limited TCR repertoire against autologous tumors.
|
9378549 |
1997 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
However, the effect of high penetrance tumor susceptibility genes such as APC, BRCA1, BRAC2, MSH1, MLH2 and MSH6 only accounts for a small fraction of these cancers.
|
20417090 |
2010 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer.
|
10090594 |
1999 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We assessed the importance of mutations in the regulatory domain, located within exon 3 of CTNNB1, in 103 rectal carcinomas and correlated these data with presence of microsatellite instability, somatic frame-shift alterations of the TCF-4 gene, and APC-gene mutations in the tumors.
|
11454429 |
2001 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Germ-line mutations of the tumor suppressor APC are implicated in attenuated adenomatous polyposis coli (AAPC), a variant of familial adenomatous polyposis (FAP).
|
9585611 |
1998 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The adenomatous polyposis coli (APC) gene is a tumor suppressor gene which is mutated in the hereditary disease, familial adenomatous polyposis (FAP).
|
21518821 |
2011 |
|
Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Genetic alterations of the von Hippel-Lindau (VHL) tumor suppressor gene and the adenomatous polyposis coli (APC) gene in renal tumors were examined by PCR-SSCP analysis and direct sequencing.
|
9143408 |
1997 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The APC gene was mutated in seven (35%) L-NIN, two (22%) H-NIN, and two (9%) Ca-NIN tumors; APC mutations were significantly more frequent in L-NIN compared with Ca-NIN tumors (p < 0.05).
|
12480914 |
2002 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Cancers in which mutations have been identified in putative tumor suppressor genes, such as the TP53 gene, the retinoblastoma (RBI) gene, the adenomatous polyposis coli (APC) gene, and the Wilms tumor (WTI) gene, frequently show loss of the corresponding allele on the homologous chromosome.
|
7513541 |
1994 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
A novel microdissection procedure was applied to correlate p53 and APC allelic loss with histologic type and tumor stage (mucosal vs. invasive cancer) in formalin-fixed, paraffin-embedded specimens of 25 gastric cancers.
|
9990480 |
1998 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Examples include the RB1 gene for retinoblastoma; the WT1 gene for Wilms' tumor; germline p53 mutations in families with the Li-Fraumeni syndrome; the NF1 and NF2 genes for neuroblastomatosis, types 1 and 2; the VHL gene for renal cancer and other tumors associated with Von Hippel-Lindau disease; the APC gene for adenomatous polyposis coli; the BRCA1 gene for hereditary breast and ovarian cancer; and the mismatch repair genes for colon and other common cancers.
|
8741802 |
1995 |
|
Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
A previously described polymorphism at codon 1493 of the APC gene was detected in 8 tumors and 3 cell lines.
|
11956582 |
2002 |