Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Colon cancer. Molecular biology of the APC protein.
|
9296069 |
1997 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
APC, a negative regulator of Wnt signaling, decreased SF1-mediated activation of the MISRII promoter in the colon carcinoma cell line SW480.
|
12724325 |
2003 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APC gene mutations have been associated to have a role in colon cancer and since gastric and colon tumors share some common genetic lesions, it is relevant to investigate the role of APC tumor suppressor gene in gastric cancer.
|
28576136 |
2017 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A database is described in which over 700 mutations in the human APC gene of tumors (colon cancer predominantly) are compiled from the literature.
|
8594558 |
1996 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A subset of cases is associated with colon cancer and APC germline mutations (Turcot syndrome), and APC and beta-catenin point mutations occur in up to 10% of sporadic cases, indicating the involvement of the Wnt pathway in the development of medulloblastoma.
|
12555076 |
2003 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Among 10 FZD gene family members, FZD7 mRNA was predominantly expressed in six colon cancer cell lines with APC or CTNNB1 mutation.
|
18592008 |
2008 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Carriers with mutations in the APC gene develop polyps in the colon and rectum which if not managed, transition into colon cancer.
|
30256815 |
2018 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention.
|
21885812 |
2011 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Conventional adenomas arise from mutation of the APC gene; progression to colon cancer is a multistep process.
|
18313537 |
2008 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Defects in the APC-beta-catenin pathway are common in colon cancer.
|
10507776 |
1999 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deletion analysis indicated that the N-terminal region of the APC protein mediated its junctional localisation, consistent with our observation that truncated APC proteins in colon cancer cell lines are still capable of localising to the cell cortex.
|
16423286 |
2006 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Differential expression of microRNAs in tumors from chronically inflamed or genetic (APC(Min/+)) models of colon cancer.
|
21532750 |
2011 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ethanol-induced mast cell-mediated inflammation leads to increased susceptibility of intestinal tumorigenesis in the APC Δ468 min mouse model of colon cancer.
|
23320800 |
2013 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer.
|
11751382 |
2001 |
Colon Carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Expression of p16(INK4A) and APC genes is regulated by DNA methylation in three human colon cancer cell lines.
|
12970888 |
2003 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, transient transfection of an APC segment encoding amino acids 2140-2421 into a colon cancer cell line with mutant APC prevents cell cycle progression into or through S phase.
|
18474248 |
2008 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations of APC in patients with Turcot syndrome (colon cancer and medulloblastoma), was well as somatic mutations of APC, beta-catenin, and Axin in sporadic medulloblastomas (MBs) have shown the importance of WNT signaling in the pathogenesis of MB.
|
15077159 |
2004 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Heme induces multiple genetic alterations by regulating WNT signalling pathway and causing mutations in major colon cancer genes such as APC, TP53 and KRAS.
|
29759553 |
2018 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we report the disruption of the APC gene caused by somatic insertion of a long interspersed repetitive element (LINE-1 sequence) into the last exon of the APC gene in a colon cancer.
|
1310068 |
1992 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we report a de novo germline mutation of APC as the causal variant in a Chinese family with inheritable colon cancer by the next generation sequencing.
|
24735542 |
2014 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we report that the expression status of adenomatous polyposis coli (APC) protein determines the relative sensitivity of colon cancer cells to HDAC inhibitor-induced apoptosis.
|
16982769 |
2006 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
HGUE-C-1 represents a novel and peculiar colon carcinoma model to study chemoresistance to chemotherapeutic agents and to novel anti-neoplasic drugs that interrupt signalling pathways such as the APC/βcatenin, Ras/Raf/Mek/Erk, PI3K/mTOR/p70S6K pathways as well as histone regulation mechanisms.
|
25885658 |
2015 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
High-resolution banding studies indicated that the deletion in the patient with polyposis spans the region 5q21-q22, which includes APC, a gene involved in familial adenomatous polyposis and sporadic colon cancer.
|
1315124 |
1992 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Immunohistochemical analyses of colon cancer in I1307K APC mutation carriers compared with noncarriers.
|
12822869 |
2003 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a series of 11 microsatellite stable (MSS) and 9 microsatellite unstable (MSI) colon cancer cell lines and primary colon carcinomas (25 MSS and 28 MSI) with known ploidy stem line and APC, KRAS, and TP53 mutation status, we analyzed the promoter methylation of the following genes: hMLH1, MGMT, p16INK4a (CDKN2A alpha-transcript), p14ARF (CDKN2A beta-transcript), APC, and E-cadherin (CDH1).
|
15476557 |
2004 |