APC, APC regulator of WNT signaling pathway, 324

N. diseases: 703; N. variants: 681
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group BEFREE Our results support the hypothesis that <i>APC</i>-mutant colorectal tumors are transcriptionally distinct from <i>APC</i>-wild-type colorectal tumors with canonical WNT signaling activated by other mechanisms, with possible implications for stratification and prognosis.<b>Significance:</b> These findings suggest that colon adenomas driven by APC mutations are distinct from those driven by WNT gain-of-function mutations, with implications for identifying at-risk patients with advanced disease based on gene expression patterns.<i></i>. 29212857 2018
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker group BEFREE These results support (i) that vitamin D, alone or in combination with calcium, may modify APC, β-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms; (ii) vitamin D as a potential chemopreventive agent against colorectal neoplasms; and (iii) the potential of APC, β-catenin, and E-cadherin expression as treatable, pre-neoplastic risk biomarkers for colorectal neoplasms. 27254743 2017
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group BEFREE Both O<sup>6</sup>-MeG and HCA-induced DNA adducts are linked to the occurrence of KRAS and APC mutations in colorectal tumors of rodents and humans, thereby driving CRC initiation and progression. 27693244 2017
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker group MGD TNIK inhibition abrogates colorectal cancer stemness. 27562646 2016
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker group BEFREE APC and KRAS were mutated at significantly lower rates in tumors from patients with IBD than in sporadic colorectal tumors (13% and 20% of cases, respectively). 26764183 2016
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group CLINVAR Genetic analysis in APC, KRAS, and TP53 in patients with stomach and colon cancer. 24861525 2015
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group BEFREE Finally, sequencing and fluorescence in situ hybridization analysis of the gene APC underlined that a somatic UPD event might represent the second hit to achieve biallelic inactivation of this TSG in colorectal tumors. 26243311 2015
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group CLINVAR A unique profile of adenomatous polyposis coli gene mutations in Iranian patients suffering sporadic colorectal cancer. 24518971 2014
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group CLINVAR HD chromoendoscopy coupled with DNA mass spectrometry profiling identifies somatic mutations in microdissected human proximal aberrant crypt foci. 24651453 2014
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker group BEFREE Colorectal tumors from APC*I1307K carriers principally harbor somatic APC mutations outside the A8 tract. 24416237 2014
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group BEFREE Analysis of colorectal tumors identified somatic APC mutations in the cluster region in all polyps, but no loss of heterozygosity was detected in any polyp. 25324480 2014
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group BEFREE We further show that loss of heterozygosity of the APC gene in tumors from carriers of the APC*E1317Q mutation may involve the mutated allele, not just the wild-type allele, suggesting the APC*E1317Q missense mutation may not be pathologically significant in the development of colorectal tumors. 23846443 2013
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group CLINVAR Targeted sequencing of cancer-related genes in colorectal cancer using next-generation sequencing. 23700467 2013
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker group BEFREE Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumors. 23397547 2013
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group BEFREE A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. 23539443 2013
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group CLINVAR Comprehensive mutation analysis in colorectal flat adenomas. 22848674 2012
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group CLINVAR A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas. 23204322 2012
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group CLINVAR Comprehensive molecular characterization of human colon and rectal cancer. 22810696 2012
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group BEFREE Consequently, loss or mutation of the APC gene causes colorectal tumors in humans and mice. 21366352 2011
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker group CTD_human 4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron. 21967605 2011
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation group CLINVAR Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients. 21901162 2011
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker group CTD_human Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. 21531761 2011
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker group CTD_human Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. 21291235 2011