Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Our results support the hypothesis that <i>APC</i>-mutant colorectal tumors are transcriptionally distinct from <i>APC</i>-wild-type colorectal tumors with canonical WNT signaling activated by other mechanisms, with possible implications for stratification and prognosis.<b>Significance:</b> These findings suggest that colon adenomas driven by APC mutations are distinct from those driven by WNT gain-of-function mutations, with implications for identifying at-risk patients with advanced disease based on gene expression patterns.<i></i>.
|
29212857 |
2018 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
These results support (i) that vitamin D, alone or in combination with calcium, may modify APC, β-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms; (ii) vitamin D as a potential chemopreventive agent against colorectal neoplasms; and (iii) the potential of APC, β-catenin, and E-cadherin expression as treatable, pre-neoplastic risk biomarkers for colorectal neoplasms.
|
27254743 |
2017 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Both O<sup>6</sup>-MeG and HCA-induced DNA adducts are linked to the occurrence of KRAS and APC mutations in colorectal tumors of rodents and humans, thereby driving CRC initiation and progression.
|
27693244 |
2017 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
MGD |
TNIK inhibition abrogates colorectal cancer stemness.
|
27562646 |
2016 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
APC and KRAS were mutated at significantly lower rates in tumors from patients with IBD than in sporadic colorectal tumors (13% and 20% of cases, respectively).
|
26764183 |
2016 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Genetic analysis in APC, KRAS, and TP53 in patients with stomach and colon cancer.
|
24861525 |
2015 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Finally, sequencing and fluorescence in situ hybridization analysis of the gene APC underlined that a somatic UPD event might represent the second hit to achieve biallelic inactivation of this TSG in colorectal tumors.
|
26243311 |
2015 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
A unique profile of adenomatous polyposis coli gene mutations in Iranian patients suffering sporadic colorectal cancer.
|
24518971 |
2014 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
HD chromoendoscopy coupled with DNA mass spectrometry profiling identifies somatic mutations in microdissected human proximal aberrant crypt foci.
|
24651453 |
2014 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
Colorectal tumors from APC*I1307K carriers principally harbor somatic APC mutations outside the A8 tract.
|
24416237 |
2014 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Analysis of colorectal tumors identified somatic APC mutations in the cluster region in all polyps, but no loss of heterozygosity was detected in any polyp.
|
25324480 |
2014 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
We further show that loss of heterozygosity of the APC gene in tumors from carriers of the APC*E1317Q mutation may involve the mutated allele, not just the wild-type allele, suggesting the APC*E1317Q missense mutation may not be pathologically significant in the development of colorectal tumors.
|
23846443 |
2013 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Targeted sequencing of cancer-related genes in colorectal cancer using next-generation sequencing.
|
23700467 |
2013 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumors.
|
23397547 |
2013 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.
|
23539443 |
2013 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Comprehensive mutation analysis in colorectal flat adenomas.
|
22848674 |
2012 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.
|
23204322 |
2012 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Comprehensive molecular characterization of human colon and rectal cancer.
|
22810696 |
2012 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Consequently, loss or mutation of the APC gene causes colorectal tumors in humans and mice.
|
21366352 |
2011 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
CTD_human |
4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron.
|
21967605 |
2011 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients.
|
21901162 |
2011 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
CTD_human |
Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.
|
21531761 |
2011 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
CTD_human |
Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression.
|
21291235 |
2011 |