APC, APC regulator of WNT signaling pathway, 324

N. diseases: 703; N. variants: 681
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps
0.490 Biomarker phenotype BEFREE CtBP interacts with adenomatous polyposis coli (APC) protein, and is stabilized in both APC-mutated human colon cancers and Apc<sup>min/+</sup> intestinal polyps. 28414304 2017
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps
0.490 GeneticVariation phenotype BEFREE Our findings show that 150 ppm OSU-HDAC42 significantly inhibited small-intestinal polyps (>46%; P < 0.001), with polyp size measuring >1 mm (P < 0.001), and colon tumors (>26%) in APC(min/+)mice, whereas 300 ppm SAHA showed nonsignificant inhibition. 24218540 2014
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps
0.490 Biomarker phenotype BEFREE SMAC deficiency also significantly increased the incidence of spontaneous intestinal polyps in APC(Min/+) mice. 22751125 2013
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps
0.490 Biomarker phenotype BEFREE Immunohistochemical analysis showed that silibinin dose-dependently decreases (P < 0.001) proliferation and induces (P < 0.001) apoptosis only in intestinal polyps without any considerable effects on normal crypt-villi in APC (min/+) or wild-type mice. 19779968 2009
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps
0.490 Biomarker phenotype CTD_human As with cyclooxygenase (COX)-2, genetic disruption of COX-1 gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in Apc gene-deficient mice. 14991580 2004
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps
0.490 Biomarker phenotype BEFREE APC(Min)/+ mice were randomised to receive the PPAR activator methylclofenapate 25 mg/kg or vehicle for up to 16 weeks, and small and large intestinal polyps were quantified by image analysis. 12912864 2003
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps
0.490 Biomarker phenotype BEFREE Numerous studies have also demonstrated that COX-2 selective inhibitors suppress intestinal polyp formation in Apc gene-mutant mice, and xenografted cancer cell growths. 11945149 2002
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps
0.490 Biomarker phenotype CTD_human When Apc gene knockout mice (APC1309 mice) were given 600 or 1200 p.p.m. mofezolac in their diet for 8 weeks, the numbers of intestinal polyps were also dose-dependently decreased, with reduction to 59% of that in the control diet group at the higher dose. 12189188 2002
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps
0.490 Biomarker phenotype BEFREE Mutations in the adenomatous polyposis coli gene (which encodes a protein called APC) are associated with the formation of intestinal polyps and colon cancers. 8990193 1997
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps
0.490 Biomarker phenotype CTD_human Effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on intestinal polyp development in Apc delta 716 knockout mice. 8561861 1996
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps
0.490 GeneticVariation phenotype BEFREE Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. 7753829 1995
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps
0.490 Biomarker phenotype BEFREE These results rule out any dominant negative mechanisms in which the truncated APC protein is directly involved in the formation of intestinal polyps in the mouse. 7796392 1995
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps
0.490 CausalMutation phenotype CLINVAR