Intestinal Polyps
|
0.490 |
Biomarker
|
phenotype |
BEFREE |
CtBP interacts with adenomatous polyposis coli (APC) protein, and is stabilized in both APC-mutated human colon cancers and Apc<sup>min/+</sup> intestinal polyps.
|
28414304 |
2017 |
Intestinal Polyps
|
0.490 |
GeneticVariation
|
phenotype |
BEFREE |
Our findings show that 150 ppm OSU-HDAC42 significantly inhibited small-intestinal polyps (>46%; P < 0.001), with polyp size measuring >1 mm (P < 0.001), and colon tumors (>26%) in APC(min/+)mice, whereas 300 ppm SAHA showed nonsignificant inhibition.
|
24218540 |
2014 |
Intestinal Polyps
|
0.490 |
Biomarker
|
phenotype |
BEFREE |
SMAC deficiency also significantly increased the incidence of spontaneous intestinal polyps in APC(Min/+) mice.
|
22751125 |
2013 |
Intestinal Polyps
|
0.490 |
Biomarker
|
phenotype |
BEFREE |
Immunohistochemical analysis showed that silibinin dose-dependently decreases (P < 0.001) proliferation and induces (P < 0.001) apoptosis only in intestinal polyps without any considerable effects on normal crypt-villi in APC (min/+) or wild-type mice.
|
19779968 |
2009 |
Intestinal Polyps
|
0.490 |
Biomarker
|
phenotype |
CTD_human |
As with cyclooxygenase (COX)-2, genetic disruption of COX-1 gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in Apc gene-deficient mice.
|
14991580 |
2004 |
Intestinal Polyps
|
0.490 |
Biomarker
|
phenotype |
BEFREE |
APC(Min)/+ mice were randomised to receive the PPAR activator methylclofenapate 25 mg/kg or vehicle for up to 16 weeks, and small and large intestinal polyps were quantified by image analysis.
|
12912864 |
2003 |
Intestinal Polyps
|
0.490 |
Biomarker
|
phenotype |
BEFREE |
Numerous studies have also demonstrated that COX-2 selective inhibitors suppress intestinal polyp formation in Apc gene-mutant mice, and xenografted cancer cell growths.
|
11945149 |
2002 |
Intestinal Polyps
|
0.490 |
Biomarker
|
phenotype |
CTD_human |
When Apc gene knockout mice (APC1309 mice) were given 600 or 1200 p.p.m. mofezolac in their diet for 8 weeks, the numbers of intestinal polyps were also dose-dependently decreased, with reduction to 59% of that in the control diet group at the higher dose.
|
12189188 |
2002 |
Intestinal Polyps
|
0.490 |
Biomarker
|
phenotype |
BEFREE |
Mutations in the adenomatous polyposis coli gene (which encodes a protein called APC) are associated with the formation of intestinal polyps and colon cancers.
|
8990193 |
1997 |
Intestinal Polyps
|
0.490 |
Biomarker
|
phenotype |
CTD_human |
Effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on intestinal polyp development in Apc delta 716 knockout mice.
|
8561861 |
1996 |
Intestinal Polyps
|
0.490 |
GeneticVariation
|
phenotype |
BEFREE |
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.
|
7753829 |
1995 |
Intestinal Polyps
|
0.490 |
Biomarker
|
phenotype |
BEFREE |
These results rule out any dominant negative mechanisms in which the truncated APC protein is directly involved in the formation of intestinal polyps in the mouse.
|
7796392 |
1995 |
Intestinal Polyps
|
0.490 |
CausalMutation
|
phenotype |
CLINVAR |
|
|
|