APC, APC regulator of WNT signaling pathway, 324

N. diseases: 703; N. variants: 681
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 GeneticVariation group BEFREE Endoscopic findings of GN and background mucosa, and histopathological findings, including phenotypic expression of GN and mutation locus of adenomatous polyposis coli (APC) gene, were evaluated. 31411765 2019
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 Biomarker group BEFREE The truncated APC gene retained 3 repeats in 88% (7/8) of FAP duodenal tumors, 100% (26/26) of gastric tumors retained 2 or 3 repeats and 83% (5/6) of desmoid tumors retained 2 repeats. 18224684 2008
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 GeneticVariation group BEFREE These results suggest that genetic alteration of a region of APC commonly mutated in colorectal cancer is not a common event during sporadic gastric tumor development, at least in patients from North-Central Italy. 8649856 1996
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 GeneticVariation group BEFREE Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors. 8259518 1993
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 Biomarker group HPO
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 Biomarker group CTD_human
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 CausalMutation group CLINVAR
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 GeneticVariation group CLINVAR
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.640 CausalMutation group CGI