HP, haptoglobin, 3240

N. diseases: 464; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.600 GeneticVariation disease BEFREE The haptoglobin 2-2 genotype is associated with cardiac autonomic neuropathy in type 1 diabetes: the RETRO HDLc study. 31529337 2020
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker disease BEFREE Haptoglobin Phenotype Modulates Lipoprotein-Associated Risk for Preeclampsia in Women With Type 1 Diabetes. 31219590 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Significantly, compared to non-diabetics, BVRA and PKCζ expression was low and haptoglobin was high in T2D patients leukocytes. 31065010 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE An Okinawan-based Nordic diet improves glucose and lipid metabolism in health and type 2 diabetes, in alignment with changes in the endocrine profile, whereas zonulin levels are elevated. 30936958 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Serum Hp levels in T2DM patients and non-DM subjects were 103.40 (72.46, 131.99) mg/dL and 100.20 (53.99, 140.66) mg/dL, respectively. 30634984 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Urine Haptoglobin/Creatinine Ratio Correlates with Tubular Injury Biomarkers and Severity of Albuminuria in Type 2 Diabetes Patients. 31505705 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE The genetic variant rs2000999 was not associated with diabetic macrovascular diseases but showed an association with metabolic traits and serum Hp levels in Chinese patients with type 2 diabetes. 30366827 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Our findings suggest that serum Hp levels may be used as a potential biomarker for the early diagnosis and monitoring of DKD in T2DM patients. 31545979 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE <b>Conclusions:</b> These results suggest that subjects with type 2 diabetes carrying the Hp 1-1 genotype may have higher susceptibility to depression in the context of white matter damage and frontal lobe atrophy. 30809196 2019
Diabetes Mellitus, Insulin-Dependent
0.600 GeneticVariation disease BEFREE The Hp genotypes have been associated with microvascular and macrovascular complications in type 1 diabetes mellitus but the association in type 2 diabetes is more consistent with cardiovascular complications. 29799294 2018
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression disease BEFREE Proinflammatory cytokines and lipopolysaccharides were increased in type 1 diabetes, and gut permeability (determined by zonulin levels) was significantly increased in type 1 diabetes and MODY2. 30224347 2018
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker disease BEFREE Some new biomarkers have been suggested for diagnosis of CD including ischemia-modified albumin (IMA), soluble syndecan-1 (SSDC-1), regenerating gene Iα (REG-Iα), Neurotensin, and Zonulin, which can be useful for diagnosis and screening of CD in childhood T1D. 30214462 2018
Diabetes Mellitus, Insulin-Dependent
0.600 GeneticVariation disease BEFREE Haptoglobin(Hp) 2-2 genotype has been shown to increase coronary artery disease (CAD) risk in numerous type 2 diabetes studies but in only one type 1 diabetes cohort. 27539884 2018
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker disease BEFREE Is Magnetic Resonance Imaging Detection of Kidney Iron Deposition Increased in Haptoglobin 2-2 Genotype Carriers with Type 1 Diabetes? 29298491 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Author Correction: Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians. 30190539 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE When combined with the glycation level of lysine-141 of haptoglobin, diagnostic accuracy improved further for newly diagnosed (SN, 94%; SP 96%) and long-term controlled (SN, 85%; SP, 94%) T2DM patients (HbA1c: SN, 88%; SP, 96%). 29943387 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Haptoglobin(Hp) 2-2 genotype has been shown to increase coronary artery disease (CAD) risk in numerous type 2 diabetes studies but in only one type 1 diabetes cohort. 27539884 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE We investigated whether serum Hp has a causal effect on macroangiopathy via Mendelian randomization (MR) analysis with common variants of the Hp gene in Chinese patients with type 2 diabetes. 29338727 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians. 29572449 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE The Hp genotypes have been associated with microvascular and macrovascular complications in type 1 diabetes mellitus but the association in type 2 diabetes is more consistent with cardiovascular complications. 29799294 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.600 GeneticVariation disease BEFREE The haptoglobin 2-2 genotype is associated with lower haptoglobin concentrations and atherosclerosis in diabetes. 28830235 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Haptoglobin 1-1 Genotype Modulates the Association of Glycemic Control With Hippocampal Volume in Elderly Individuals With Type 2 Diabetes. 28860127 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE A positive correlation was observed between Zo and LPS in T2DM-CKD subjects. 28925931 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE To collectively evaluate the association between haptoglobin (Hp) gene variants and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). 28758129 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE The distribution of Hp2 allele was higher in T2DM subjects compared to nondiabetic controls and the HbA1c levels of T2DM subjects carrying at least one Hp2 allele tended to be higher than T2DM subjects with Hp 1-1. 28218436 2017