|
4-hydroxyphenylacetic aciduria
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
4-Hydroxyphenylpyruvic aciduria
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of the liver
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Absence of sensation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
To measure the plasma concentrations of three endogenous opioid peptides and the levels of preproenkephalin (PPE) and preprodynorphin (PPD) mRNA in peripheral blood lymphocytes of patients during scheduled surgery performed under intravenous general anaesthesia combined with an epidural block.
|
24743873 |
2014 |
|
Active tuberculosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To describe the factors associated with the induction of monocyte mitochondrial and membrane damage in response to PPD as well as determine if this type of damage might predict the susceptibility of developing active tuberculosis in a cohort of household contacts (HHCs) from Medellin, Colombia from 2005 to 2008.
|
28222109 |
2017 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of 4-hydroxyphenylpyruvate dioxygenase may prevent the development of liver cirrhosis and abolish or diminish the risk of liver cancer.
|
1383656 |
1992 |
|
Amyloidosis cutis dyschromia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conclusion: The high level of skin sensitization due to nickel, PPD, and gold in patients with ACD emphasizes the need for measures to decrease exposure to these sensitizing agents.
|
28889150 |
2017 |
|
androgen independent prostate cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our preclinical data indicate that 25-OCH3-PPD is a potential therapeutic agent against both androgen-dependent and androgen-independent prostate cancer.
|
18253123 |
2008 |
|
Anemia of chronic disease
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Conclusion: The high level of skin sensitization due to nickel, PPD, and gold in patients with ACD emphasizes the need for measures to decrease exposure to these sensitizing agents.
|
28889150 |
2017 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The fragile X syndrome was the most common genetic abnormality detected, presented by 1 patient with autism and 1 patient with PPD not-otherwise specified (PPD-NOS).
|
11916331 |
2002 |
|
Avellino corneal dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conclusion: The high level of skin sensitization due to nickel, PPD, and gold in patients with ACD emphasizes the need for measures to decrease exposure to these sensitizing agents.
|
28889150 |
2017 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Similarly, the Western blot results further confirmed the increased expression of HPD in breast cancer compared with cancer-adjacent normal tissues (P < 0.05).
|
31277952 |
2019 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In summary, 25-OCH(3)-PPD is a potential therapeutic and anti-metastatic agent for human breast cancer through down-regulating MDM2.
|
22911819 |
2012 |
|
Bronchitis, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Sequence variation in the hpd gene of nonencapsulated Haemophilus influenzae isolated from patients with chronic bronchitis.
|
9210589 |
1997 |
|
Buruli Ulcer
|
0.010 |
Biomarker
|
disease |
BEFREE |
To assess the potential for a serodiagnostic test, we measured the humoral immune response of BU patients to M. ulcerans antigens and compared this response with delayed-type hypersensitivity responses to both Burulin and PPD.
|
10756149 |
2000 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
However, the precise contribution of HPD to cancer metabolism and tumorigenesis remains unclear.
|
31285420 |
2019 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that HPD was highly expressed in lung cancer and its higher expression correlated with poor prognosis in lung cancer patients.
|
31285420 |
2019 |
|
Cardiovascular Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
These results suggest that the genotype of the mutant LDL receptor allele was independently associated with variations in LDL-PPD and could partly explain why negative-receptor FH heterozygotes may be at greater risk of cardiovascular disease than defective-receptor FH subjects.
|
15899484 |
2006 |
|
Chemical and Drug Induced Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase.
|
22872058 |
2012 |
|
Chemical and Drug Induced Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
|
16099942 |
2005 |
|
Chemically-Induced Liver Toxicity
|
0.300 |
Biomarker
|
disease |
CTD_human |
A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase.
|
22872058 |
2012 |
|
Chemically-Induced Liver Toxicity
|
0.300 |
Biomarker
|
disease |
CTD_human |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
|
16099942 |
2005 |
|
Contact Dermatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In vitro PPD and nickel sulphate lymphocyte blast transformation reactions were performed in ten families with one or more allergic nickel contact dermatitis patients.
|
7233093 |
1981 |
|
Craniofacial Abnormalities
|
0.010 |
Biomarker
|
group |
BEFREE |
GCPS is mainly characterised by craniofacial abnormalities (macrocephaly/prominent forehead, hypertelorism) and limb malformations, such as PPD-IV, syndactyly and postaxial polydactyly type A or B (PAPA/B).
|
22903559 |
2012 |