AIRE, autoimmune regulator, 326

N. diseases: 175; N. variants: 85
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome
0.220 Biomarker disease BEFREE Peripheral neuropathies characteristic of SS appear to be tightly linked with the underlying immunopathological mechanism and Aire -/- mice provide an excellent tool to explore the interplay between SS-associated immunopathology and peripheral neuropathy. 28926640 2017
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome
0.220 Biomarker disease BEFREE IL1alpha, IL1beta, IL6, IFNgamma, and TNFalpha induced SPRR1B expression in vitro and the local expression of IL1beta and IFNgamma was elevated in ocular tissues of patients with SS and aire-deficient mice. 18172072 2008
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome
0.220 Biomarker disease MGD Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. 15699112 2005