HRAS, HRas proto-oncogene, GTPase, 3265

N. diseases: 698; N. variants: 29
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE A cellular model reflecting the phenotypic heterogeneity of mutant HRAS driven squamous cell carcinoma. 27074337 2016
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE Multivariate analysis in patients who received adjuvant CRT for 1-3 ECEs (i.e., those with a favorable expected prognosis) identified the following adverse prognostic factors: 1) margin of < 5 mm for locoregional failure (66% versus 30%, P = 0.007) and DSS (42% versus 63%, P = 0.039); 2) HRAS mutation for distant failure (55% versus 25%, P = 0.007) and DSS (36% versus 63%, P = 0.024); and 3) TP53 DNA-binding domain missense mutations for DSS (52% versus 71%, P = 0.025) and overall survival (39% versus 61%, P = 0.007).We conclude that genetic information from NGS may improve the prognostic stratification offered by traditional prognosticators in resected OSCC patients with ECE. 27590518 2016
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker disease BEFREE In addition, within the BRAF inhibitor-associated group, the lesions designated as KAs and BRAF inhibitor-associated verrucous keratoses had a similar mutational profile (mutations in PIK3CA, APC, and HRAS), which was distinct to that seen in squamous cell carcinomas (FGFR3, CDKN2A, and STK11). 26319365 2015
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker disease CTD_human Functional kinomics identifies candidate therapeutic targets in head and neck cancer. 25125259 2014
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE HA-RAS mutations are rare in human SCC, but HA-RAS-mutated tumors appear in melanoma patients treated with B-raf inhibitors, indicating that initiated, HA-RAS-mutated stem cells also reside in human skin. 23266722 2013
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker disease CTD_human Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin. 24224046 2013
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker disease BEFREE Exome sequencing (n=50) and recurrence testing (n=60) reveals that some significantly and frequently altered genes are specific to OSCC-GB (USP9X, MLL4, ARID2, UNC13C and TRPM3), while some others are shared with HNSCC (for example, TP53, FAT1, CASP8, HRAS and NOTCH1). 24292195 2013
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE Novel mutations of the HRAS gene and absence of hotspot mutations of the BRAF genes in oral squamous cell carcinoma in a Greek population. 22294102 2012
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE We analysed the presence of EGFR and concomitant HRAS mutations in a German cohort of 31 patients with cutaneous SCC by direct sequencing of EGFR and SNaPshot analysis of concomitant RAS mutations. 21771097 2011
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE Both HRAS mutant SCC and BCC biopsies were HPV- and CMV-positive, as well. 19849697 2010
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker disease BEFREE Protein kinase C (PKC)-delta is proapoptotic in human keratinocytes, and is downregulated or inactivated in keratinocytes expressing the activated Ha-ras oncogene, making it a candidate tumor suppressor gene for squamous cell carcinoma (SCC). 16158048 2006
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE In the present studies, we investigated the correlation between RASSF1A promoter methylation status and Kras2 mutations in 65 primary non small cell lung cancer (NSCLC) including 33 adenocarcinomas, 12 large cell carcinomas, and 20 squamous cell carcinomas. 14511407 2004
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE Squamous cell carcinomas in psoralen-plus-ultraviolet A (PUVA) treated patients frequently exhibit p53 tumor suppressor genes and Ha-ras protooncogenes that are mutated at dipyrimidine sites and carry the ultraviolet fingerprint (i.e., C-to-T or CC-to-TT transitions). 12648234 2003
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease LHGDN The aim of the study was to assess the frequency of Ha-ras oncogene mutations in cervical intraepithelial neoplasia (CIN) grade III and invasive squamous cell carcinomas and to examine this genetic factor in relation to HPV infection and the clinical evolution of cervical lesions. 12878090 2003
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE The aim of the study was to assess the frequency of Ha-ras oncogene mutations in cervical intraepithelial neoplasia (CIN) grade III and invasive squamous cell carcinomas and to examine this genetic factor in relation to HPV infection and the clinical evolution of cervical lesions. 12878090 2003
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE Point mutations in codon 61 of the human Ha-ras gene were detected in the SCC, five of six analyzed actinic keratoses and in non-lesional epidermis of DMBA- and UVB-treated grafts, indicating that DMBA as well as UVB alone can induce these mutations in human skin. 11756239 2002
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker disease BEFREE We have utilized an in vitro correlate of squamous cell carcinogenesis, in which progression stages from normal squamous epithelium to dysplastic lesions and to SCC are represented by primary cultures of normal keratinocytes, by human papilloma virus-immortalized keratinocytes (UP) and by HPVimmortalized/v-Ha-ras transfected tumorigenic keratinocytes (UPR). 10783309 2000
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker disease BEFREE Alterations of p53 gene and Ha-ras gene are independent events in solar keratosis and squamous cell carcinoma. 9778107 1998
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE Characteristic codon 61 mutations in the Ha-ras gene were found in most of the papillomas and SCCs induced by DMBA and TPA in transgenic as well as nontransgenic mice. 9115586 1997
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE Our previous reports have shown that two thirds of 4-nitroquinoline-1-oxide (4NQO)-induced murine oral squamous cell carcinomas (SCC) have Hras1 mutations. 9294609 1997
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker disease BEFREE Using Southern blot and ISH, c-myc and/or c-Ha-ras gene amplification was detected in 7/13 SCC tested. 8907200 1996
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE Topographic genotyping with subsequent polymerase chain reaction (PCR) and sequence analysis of K-ras-2 showed mutations in significantly fewer cases of PC (9%, 2 of 22 cases) than in AdC (36%, 35 of 97 cases) or SqC (0%, 0 of 42 cases) (P < .001). 8853037 1996
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE The Ha-ras mutations (61A-->T transversions in the second position) were found in five of 29 (17%) samples (one dysplasia and four SCCs). 8519419 1995
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE Mutated ras genes have been found to be conspicuously absent from primary tumors of the esophagus, although high expression of ras p21 oncoprotein in some esophageal squamous cell carcinomas and mutations of the Ki- and Ha-ras genes in esophageal carcinoma cell lines have been reported. 8519418 1995
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation disease BEFREE A novel mutation in codon 6 of the Ki-ras gene was detected in a squamous cell carcinoma. 7916998 1994