melanoma
|
0.800 |
Biomarker
|
disease |
CTD_human |
Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression.
|
30619488 |
2018 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The rarity of HRAS and KRAS Q61R mutants in malignant melanoma let previous investigations erroneously conclude that SP174 is specific for NRAS Q61R-mutant protein.
|
29206715 |
2018 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Few studies have focused on the transcriptional level of RAS isoforms (KRAS, NRAS, and HRAS) in cutaneous melanoma.
|
29349077 |
2017 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Integrative sequencing of cutaneous melanoma metastases using different sequencing platforms revealed a new somatic point mutation in HRAS and a structural rearrangement affecting CDKN2C (a CDK4 inhibitor).
|
23174022 |
2013 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Association between HRAS rs12628 and rs112587690 polymorphisms with the risk of melanoma in the North American population.
|
22618666 |
2012 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The second patient had malignant melanoma, in which we identified a somatic point mutation in HRAS and a structural rearrangement affecting CDKN2C.
|
22133722 |
2011 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This was in accordance with the literature: review showed that no HRAS mutations had so far been reported in Spitzoid melanomas.
|
20871217 |
2010 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
We showed that HRAS activation cooperates with Pten+/- and Ink4a/Arf-/- to increase melanoma penetrance and promote metastasis.
|
20711233 |
2010 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
To look for evidence of progression from Spitz naevi to spitzoid melanoma, HRAS was analysed in 21 spitzoid melanomas, with no mutations identified.
|
19438459 |
2009 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
We have established a model of melanoma progression in zebrafish through the generation of transgenic lines specifically expressing oncogenic human HRAS in the melanocytic lineage.
|
20047469 |
2009 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The impact of HRAS on the UPR was selective, as it was poorly induced by activated NRAS (more frequently mutated in melanoma than HRAS).
|
16964246 |
2006 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We have investigated 37 sporadic malignant melanomas (15 primary cutaneous melanomas and 22 melanoma metastases) and 6 melanoma cell lines for mutations in the 3 Ras genes NRAS, KRAS and HRAS.
|
14961576 |
2004 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
HRAS activation by either mutation or copy number increase alone could explain several of the histological features that overlap with those of melanoma.
|
10980135 |
2000 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Loci from these chromosome regions were chosen because of cytogenetic abnormalities reported in melanoma (1p, 6q, 9p), location of common oncogenes (11p-HRAS, 17p-TP53), or use in other MIN studies (5q, 18q).
|
9666803 |
1998 |
melanoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
No significant differences were detected in the c-neu and Ha-ras mRNA levels in naevi and melanomas.
|
1686168 |
1991 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Nodular melanoma, epithelioid cell type melanoma, and deeply invading melanoma revealed higher reactivity with anti-p21ras monoclonal antibody than the other types.
|
2664010 |
1989 |
melanoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The results of these studies are (1) 24% of cultured malignant melanomas have activated ras genes, with N-ras being activated ten times as frequently as Harvey (Ha)-ras.
|
2682463 |
1989 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
c-Ha-ras-1 alleles in bladder cancer, Wilms' tumour and malignant melanoma.
|
2892780 |
1988 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
These results imply that hereditary predisposition to melanoma is associated with genes other than the Ha-ras-1 locus, contradicting the original suggestion of Krontiris et al., made on the basis of either an inadequate sample size or other misleading experimental factors.
|
2879249 |
1987 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
However, the analysis of the same DNAs for a different polymorphism based on the presence of additional TaqI sites in the variable tandem repeat region of HRAS1 showed that the total frequency of a group of allelic variants, named Tp, was significantly higher in melanoma patients than in normal donors.
|
2894003 |
1987 |
melanoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Amplification of activated c-Ha-ras-1 in human melanoma.
|
3928549 |
1985 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
An SstI fragment of 2.9 kb carrying all four coding exons of the human melanoma c-Ha-ras-1 oncogene could not transform mouse NIH 3T3 cells.
|
3932274 |
1985 |
melanoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The activation of c-Ha-ras and N-ras has been described in some cell lines derived from cases of human malignant melanoma.
|
6090953 |
1984 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient.
|
6087347 |
1984 |