|
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recent studies suggest that wild-type KRAS and HRAS isoforms could majorly contribute to HCC progression and sorafenib resistance.
|
30685691 |
2019 |
|
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here, we identify WD40-repeat protein 76 (WDR76) as one of the HRAS binding proteins using proteomic analyses of hepatocellular carcinomas (HCC) tissue.
|
30655611 |
2019 |
|
Liver carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to analyze the effects of RGS in HCC and to assess PLK1 and HRAS expression in HCC.
|
29423069 |
2018 |
|
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
|
27517622 |
2016 |
|
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Wnt/beta-catenin signaling activates and determines hepatic zonal expression of glutathione S-transferases in mouse liver.
|
20118494 |
2010 |
|
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We investigated 32 HCV reverse transcriptase-polymerase chain reaction (RT-PCR) positive hepatocellular carcinoma (HCC) cases and 18 morphologically normal hepatic tissues distant to tumors (MNT) for the correlation between HCV-NS3P, p53, p21(waf), mdm2, p21ras and c-erbB2 and DNA content by immunohistochemistry and image analysis.
|
16246194 |
2005 |
|
Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
K-ras-2 mutations were found in five of 12 (42%) examined HCCs and in three cases of adjacent non-neoplastic liver tissue (25%).
|
11563603 |
2001 |
|
Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
K- ras -2 mutations were found in 6 of 18 (33%) examined VC-associated HCCs and in 3 cases of adjacent non-neoplastic liver tissue.
|
11286481 |
2001 |
|
Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In liver tumors induced by vinyl chloride, specific mutational patterns were found in the Ki-ras gene in human ASL, in the Ha-ras gene in hepatocellular carcinoma (HCC) in rats, and in the p53 gene in human and rat ASL.
|
10767618 |
2000 |
|
Liver carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The hepatocellular carcinomas in 4 males and 1 female contained a point mutation in the mouse c-H-ras gene: 3, 1, and 1 carcinomas had a CAA to AAA transversion at the first base of codon 61, a CAA to CTA transversions, and a CAA to CGA transition at the second base of codon 61, respectively.
|
9715515 |
1998 |
|
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
At week 16, rats that had received the mutated Ha-ras antisense oligonucleotides had significantly fewer and smaller preneoplastic lesions positive for glutathione-S-transferase, placental type, and had smaller hepatocellular carcinomas than rats that had received the sense oligonucleotide.
|
9311599 |
1997 |
|
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Results from a recent study of ours have demonstrated the significant role of the wild-type ras gene in the development of hepatocellular carcinoma in rasH2 mice having prototype human c-H-ras genes.
|
9195373 |
1997 |
|
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet.
|
8200073 |
1994 |
|
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results thus indicate that the genetic lesions affecting the c-Ha-ras gene do occur in human hepatocellular carcinoma and probably serve as one of the multiple steps in the process of hepatic carcinogenesis.
|
1846346 |
1991 |
|
Liver carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Erb (B), erb (A+B), Ha-ras, myc, fos and fms oncogene expression elevated in certain stages of fetal liver development and in hepatoma as compared to the normal adult human liver.
|
3030308 |
1987 |
|
Liver carcinoma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
The methylation state of cellular oncogenes (c-oncs) and epidermal growth factor (EGF) receptor gene from human liver tissues was examined by means of restriction endonuclease analysis. c-myc and EGF receptor gene from hepatocellular carcinoma and fetal liver were substantially hypomethylated in comparison with those genes from normal liver, while the extents of methylation of c-mos and c-Ki-ras genes were the same among these tissues.
|
3005205 |
1985 |