HES1, hes family bHLH transcription factor 1, 3280

N. diseases: 243; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.380 AlteredExpression disease BEFREE Notch signalling pathway affected the proliferation of breast cancer by affecting its downstream gene HES-1, and regulated the migration of breast cancer cells by affecting the expression of EMT pathway. 30809937 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.380 AlteredExpression disease BEFREE Notch signalling pathway affected the proliferation of breast cancer by affecting its downstream gene HES-1, and regulated the migration of breast cancer cells by affecting the expression of EMT pathway. 30809937 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.380 Biomarker disease BEFREE Furthermore, HES1 may be crucial in mediating the involvement of lutein in the suppression of hypoxia-driven ROS-induced breast cancer progression. 29620169 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.380 AlteredExpression disease BEFREE Our study demonstrated that HES1 upregulation is a predictor of poor prognosis in human breast cancers and might be a critical contributor to the proliferation and invasion of breast cancer cells. 29556333 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.380 AlteredExpression disease BEFREE HES1 overexpression was correlated with poor prognosis in breast cancer patients (p<0.05). 29556333 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.380 Biomarker disease BEFREE Furthermore, HES1 may be crucial in mediating the involvement of lutein in the suppression of hypoxia-driven ROS-induced breast cancer progression. 29620169 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.380 Biomarker disease BEFREE Analysis in human breast cancer datasets found the lowest HES1 and second lowest LFNG expressions in CLBC among molecular subtypes, and low level of LFNG is associated with poor survival. 28938159 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.380 Biomarker disease BEFREE The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFκB, which are involved in breast cancer stem cell maintenance. 27923595 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.380 Biomarker disease BEFREE The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFκB, which are involved in breast cancer stem cell maintenance. 27923595 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.380 Biomarker disease BEFREE Analysis in human breast cancer datasets found the lowest HES1 and second lowest LFNG expressions in CLBC among molecular subtypes, and low level of LFNG is associated with poor survival. 28938159 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.380 AlteredExpression disease BEFREE We have previously shown that the anti-proliferative effect of retinoic acid in human breast cancer cell line MCF-7 is dependent on HES-1 expression. 19322650 2010
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.380 Biomarker disease CTD_human We provide evidence that approximately 27% of ERBB2-positive human breast cancer specimens display high expression of HES1, phospho-S6RP, and GLUT1. 20197467 2010
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.380 Biomarker disease CTD_human Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation. 21036696 2010
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.380 AlteredExpression disease BEFREE We provide evidence that approximately 27% of ERBB2-positive human breast cancer specimens display high expression of HES1, phospho-S6RP, and GLUT1. 20197467 2010
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.380 Biomarker disease CTD_human Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation. 21036696 2010
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.380 AlteredExpression disease BEFREE We provide evidence that approximately 27% of ERBB2-positive human breast cancer specimens display high expression of HES1, phospho-S6RP, and GLUT1. 20197467 2010
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.380 Biomarker disease CTD_human We provide evidence that approximately 27% of ERBB2-positive human breast cancer specimens display high expression of HES1, phospho-S6RP, and GLUT1. 20197467 2010
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.380 AlteredExpression disease BEFREE We have previously shown that the anti-proliferative effect of retinoic acid in human breast cancer cell line MCF-7 is dependent on HES-1 expression. 19322650 2010
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.380 Biomarker disease BEFREE Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation. 19891787 2009
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.380 Biomarker disease BEFREE Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation. 19891787 2009
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.350 AlteredExpression disease BEFREE Colon cancer cell lines which over-expressed HES1 were more resistant to 5-Fu treatment <i>in vitro</i>. 28928869 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.350 Biomarker disease BEFREE These findings indicate that carcinogenesis in a subset of colon cancer is consequent to a molecular mechanism driven by fucosylation deficiency and/or HES1-loss. 27639802 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.350 Biomarker disease BEFREE Our results provide functional and mechanistic links between Hes1 and Bmi-1/PTEN/Akt/GSK3β signaling in the development and progression of colon cancer. 26452029 2015
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.350 Biomarker disease BEFREE Taken together, our data indicate that Hes1 induces stem-like cell self-renewal and increases the number of tumour-initiating cells in colon cancer. 24492635 2014
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.350 Biomarker disease CTD_human We first show that the Notch-1 receptor, as well as its downstream target Hes-1, is up-regulated with colon cancer progression, similar to other genes involved in chemoresistance. 19147571 2009