Malignant neoplasm of breast
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Notch signalling pathway affected the proliferation of breast cancer by affecting its downstream gene HES-1, and regulated the migration of breast cancer cells by affecting the expression of EMT pathway.
|
30809937 |
2019 |
Breast Carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Notch signalling pathway affected the proliferation of breast cancer by affecting its downstream gene HES-1, and regulated the migration of breast cancer cells by affecting the expression of EMT pathway.
|
30809937 |
2019 |
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
BEFREE |
Furthermore, HES1 may be crucial in mediating the involvement of lutein in the suppression of hypoxia-driven ROS-induced breast cancer progression.
|
29620169 |
2018 |
Malignant neoplasm of breast
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Our study demonstrated that HES1 upregulation is a predictor of poor prognosis in human breast cancers and might be a critical contributor to the proliferation and invasion of breast cancer cells.
|
29556333 |
2018 |
Breast Carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
HES1 overexpression was correlated with poor prognosis in breast cancer patients (p<0.05).
|
29556333 |
2018 |
Breast Carcinoma
|
0.380 |
Biomarker
|
disease |
BEFREE |
Furthermore, HES1 may be crucial in mediating the involvement of lutein in the suppression of hypoxia-driven ROS-induced breast cancer progression.
|
29620169 |
2018 |
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
BEFREE |
Analysis in human breast cancer datasets found the lowest HES1 and second lowest LFNG expressions in CLBC among molecular subtypes, and low level of LFNG is associated with poor survival.
|
28938159 |
2017 |
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
BEFREE |
The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFκB, which are involved in breast cancer stem cell maintenance.
|
27923595 |
2017 |
Breast Carcinoma
|
0.380 |
Biomarker
|
disease |
BEFREE |
The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFκB, which are involved in breast cancer stem cell maintenance.
|
27923595 |
2017 |
Breast Carcinoma
|
0.380 |
Biomarker
|
disease |
BEFREE |
Analysis in human breast cancer datasets found the lowest HES1 and second lowest LFNG expressions in CLBC among molecular subtypes, and low level of LFNG is associated with poor survival.
|
28938159 |
2017 |
Malignant neoplasm of breast
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
We have previously shown that the anti-proliferative effect of retinoic acid in human breast cancer cell line MCF-7 is dependent on HES-1 expression.
|
19322650 |
2010 |
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
CTD_human |
We provide evidence that approximately 27% of ERBB2-positive human breast cancer specimens display high expression of HES1, phospho-S6RP, and GLUT1.
|
20197467 |
2010 |
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
CTD_human |
Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation.
|
21036696 |
2010 |
Malignant neoplasm of breast
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
We provide evidence that approximately 27% of ERBB2-positive human breast cancer specimens display high expression of HES1, phospho-S6RP, and GLUT1.
|
20197467 |
2010 |
Breast Carcinoma
|
0.380 |
Biomarker
|
disease |
CTD_human |
Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation.
|
21036696 |
2010 |
Breast Carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
We provide evidence that approximately 27% of ERBB2-positive human breast cancer specimens display high expression of HES1, phospho-S6RP, and GLUT1.
|
20197467 |
2010 |
Breast Carcinoma
|
0.380 |
Biomarker
|
disease |
CTD_human |
We provide evidence that approximately 27% of ERBB2-positive human breast cancer specimens display high expression of HES1, phospho-S6RP, and GLUT1.
|
20197467 |
2010 |
Breast Carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
We have previously shown that the anti-proliferative effect of retinoic acid in human breast cancer cell line MCF-7 is dependent on HES-1 expression.
|
19322650 |
2010 |
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
BEFREE |
Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation.
|
19891787 |
2009 |
Breast Carcinoma
|
0.380 |
Biomarker
|
disease |
BEFREE |
Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation.
|
19891787 |
2009 |
Malignant tumor of colon
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Colon cancer cell lines which over-expressed HES1 were more resistant to 5-Fu treatment <i>in vitro</i>.
|
28928869 |
2017 |
Malignant tumor of colon
|
0.350 |
Biomarker
|
disease |
BEFREE |
These findings indicate that carcinogenesis in a subset of colon cancer is consequent to a molecular mechanism driven by fucosylation deficiency and/or HES1-loss.
|
27639802 |
2017 |
Malignant tumor of colon
|
0.350 |
Biomarker
|
disease |
BEFREE |
Our results provide functional and mechanistic links between Hes1 and Bmi-1/PTEN/Akt/GSK3β signaling in the development and progression of colon cancer.
|
26452029 |
2015 |
Malignant tumor of colon
|
0.350 |
Biomarker
|
disease |
BEFREE |
Taken together, our data indicate that Hes1 induces stem-like cell self-renewal and increases the number of tumour-initiating cells in colon cancer.
|
24492635 |
2014 |
Malignant tumor of colon
|
0.350 |
Biomarker
|
disease |
CTD_human |
We first show that the Notch-1 receptor, as well as its downstream target Hes-1, is up-regulated with colon cancer progression, similar to other genes involved in chemoresistance.
|
19147571 |
2009 |