HES1, hes family bHLH transcription factor 1, 3280

N. diseases: 243; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.310 Biomarker group CTD_human Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. 17804716 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.310 AlteredExpression group BEFREE In this study, we show that NOTCH signaling, as measured by the gamma-secretase cleavage product N(IC)-1, is active in both normal human and lung tumor samples; however, downstream NOTCH readouts (i.e., HES-1 and HES-5) are elevated in lung tumors. 17804701 2007