|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In our TMA, cIAP1 was overexpressed in HNSCC compared with normal tissues (<i>P</i> = 0.0003) and associated with a poor overall survival (<i>P</i> = 0.0402). cIAP1 levels were higher in HPV<sup>-</sup> than that in HPV<sup>+</sup>HNSCC tumors (<i>P</i> = 0.004) and patients with cIAP1<sup>+</sup>/HPV<sup>-</sup> HNSCC had the worst survival.
|
31015310 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, API-LP displayed higher systemic exposure than free API-1 in mice without apparent toxicity, resulting in an enhanced tumor inhibition in xenograft mice.
|
31367251 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In lung cancer cells, depletion of eIF4H enhances sensitization to chemotherapy, decreases cell migration and inhibits tumor growth in vivo, in association with reduced translation of mRNA encoding cell-proliferation (c-Myc, cyclin D1) angiogenic (FGF-2) and anti-apoptotic factors (CIAP-1, BCL-xL).
|
26498689 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Amplification of BIRC2 in cervical carcinomas was homogeneous as shown in corresponding whole tissue sections of amplified tumors at the tissue microarray.
|
22733500 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Increase of kinase signaling of MAP3K1 along with anti-apoptosis function of BIRC2/3 may have facilitated progression of this tumor.
|
21484931 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, API-1 inhibited tumor growth in nude mice of human cancer cells in which Akt is elevated but not of those cancer cells in which it is not.
|
20068047 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The authors investigated the activity of NF-kappaB, and the mRNA expression of TNFalpha, TNFalpha receptor, TRAF1, TRAF2, and TRAF-associated NF-kappaB activator (TANK), and the antiapoptotic genes Bcl-2, c-IAP 1 and 2, and Survivin in human astrocytic tumors.
|
18327814 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Decreased cIAP1 expression in RCC relative to paired normal samples predicted an abbreviated time to recurrence (hazard rate 2.96; 95% CI: 1.23-7.09) and tumor-specific survival (hazard rate 2.78; 95% CI: 1.22-6.38) irrespective of the tumor stage and grade.
|
17154176 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the genetic context of their amplification, both cIAP1 and Yap accelerated tumorigenesis and were required to sustain rapid growth of amplicon-containing tumors.
|
16814713 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
c-IAP2 and XIAP mRNA levels were similar among the samples, cervical tumors had lower c-IAP1 mRNA levels.
|
16504151 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemical analysis of 70 primary CSCCs from patients treated only with radiotherapy demonstrated that both overall survival and local recurrence-free survival was significantly poorer among patients with tumors showing high levels of nuclear cIAP1 staining than among patients whose tumors revealed little or no nuclear cIAP1.
|
12208731 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, hIAP-2 mRNA was nearly identical in all tumour and control samples.
|
12384799 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
An increase in cIAP1 copy number was also detected in 4 of 42 (9.5%) primary ESC tumors that were not related to the cell lines examined.
|
11559525 |
2001 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High levels of XIAP protein in tumor cell lines were unexpectedly correlated with sensitivity to some anticancer drugs, particularly cytarabine and other nucleosides, whereas higher levels of cIAP1 protein levels were associated with resistance to several anticancer drugs.
|
10815900 |
2000 |