|
Malignant neoplasm of skin
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we found a significant upregulation of 11βHSD2 protein in skin cancer cells when compared to normal skin cells, suggesting a role for this enzyme in the multifactorial process of skin cancer development.
|
30302860 |
2019 |
|
Cystic Fibrosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
4/17 individuals (approximately 25% of cases) were found to suffer in fact from pseudo-Bartter syndrome resulting from congenital chloride diarrhea due to a novel homozygous mutation in the SLC26A3 gene, Pendred syndrome due to a known homozygous mutation in SLC26A4, Cystic Fibrosis (CF) due to a novel mutation in CFTR and apparent mineralocorticoid excess syndrome due to a novel homozygous loss of function mutation in HSD11B2 gene.1 case (5%) remained unsolved.
|
30760291 |
2019 |
|
polyps
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This study investigates the role of 11β-HSD1 and 11β-HSD2 on the glucocorticoid response of CRSwNP patients and the pathogenic mechanism of these polyps.
|
30446829 |
2019 |
|
Vitamin D Deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Vitamin D deficiency reduced the expression of the glucocorticoid-inactivating enzyme Hsd11b2 in the female placenta, but did not alter maternal glucocorticoid levels, feto-placental weights, or placental expression of other glucocorticoid-related genes at mid-gestation.
|
31477207 |
2019 |
|
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
However, brain-specific HSD2 removal (HSD2BKO) also generated adult phenotypes of depressive-like behaviour and memory deficits, demonstrating the importance of fetal brain HSD2 expression in development.
|
30884491 |
2019 |
|
Skin carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, these studies highlight for the first time a potential novel role for 11βHSD2 in NMSC development and may allow for new GC treatment approaches capable of avoiding deactivation by the enzyme.
|
30302860 |
2019 |
|
Aeromonas hydrophila infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therefore, the aim of this study was to evaluate the effect of Aeromonas hydrophila infection on individual behaviour and brain expression of genes related to stress (slc6a2, hsp90, hspa12a, hsd20b, hsd11b2, crh) in silver catfish (Rhamdia quelen).
|
31078710 |
2019 |
|
Hormone refractory prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, 11βHSD2 activity, catalysing 11-ketotestosterone biosynthesis, was shown to be key in the production of prostate specific antigen and in the progression of prostate cancer to castration resistant prostate cancer.
|
30825506 |
2019 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Patients with chronic kidney disease (CKD) have dysregulated cortisol metabolism secondary to changes in 11β-hydroxysteroid dehydrogenase (11β-HSD) enzymes.
|
30358903 |
2019 |
|
Progression of prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, 11βHSD2 activity, catalysing 11-ketotestosterone biosynthesis, was shown to be key in the production of prostate specific antigen and in the progression of prostate cancer to castration resistant prostate cancer.
|
30825506 |
2019 |
|
Chronic rhinosinusitis with nasal polyps
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found a strong correlation between the response to glucocorticoids and the ratio of 11β-HSD1/11β-HSD2, which could be used as a marker in predicting the level of tissue response to glucocorticoid therapy in CRSwNP.
|
30446829 |
2019 |
|
Anorexia Nervosa
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Given the drastic metabolic disturbances in acutely underweight AN our findings could be interpreted as disturbed cortisol incorporation or altered activity of 11-β-HSD-enzymes in the hair follicle.
|
29309960 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A consensus on the role of osimertinib in non-small cell lung cancer from the AME Lung Cancer Collaborative Group.
|
30174832 |
2018 |
|
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest that age and apparent 11β-HSD2 activity modulate the association of copeptin with insulin resistance at the population level but not MeTS or diabetes.
|
29235050 |
2018 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Our data suggest that age and apparent 11β-HSD2 activity modulate the association of copeptin with insulin resistance at the population level but not MeTS or diabetes.
|
29235050 |
2018 |
|
Thyroid Nodule
|
0.010 |
Biomarker
|
disease |
BEFREE |
Differences between ATA, AACE/ACE/AME and ACR TI-RADS ultrasound classifications performance in identifying cytological high-risk thyroid nodules.
|
29626008 |
2018 |
|
Avascular Necrosis of Femur Head
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The current study demonstrated that treatment with antler extract has a therapeutic effect on ANFH induced by steroids in rabbits and may regulate the expression of 11β-HSD in femoral heads and osteoblasts, as well as promoting the proliferation of osteoblasts.
|
29434691 |
2018 |
|
Hunger
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here we show that chemogenetic activation of aldosterone-sensitive neurons that express 11β-hydroxysteroid dehydrogenase type 2 (HSD2) in the nucleus of the solitary tract is sufficient to drive consumption of sodium-containing solutions in mice, independently of thirst or hunger.
|
27918529 |
2017 |
|
Hyponatremia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
These HSD2-positive neurons are necessary for full expression of sodium appetite and have distinct downstream targets that are activated during sodium depletion.
|
27918529 |
2017 |
|
Irritable Bowel Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results have demonstrated a significant downregulation in 11β-HSD2 expression in IBD patients compared with controls (13.8 ± 17.1 au vs. 318.4 ± 521.1 au, p = 0.01), whereas levels of 11β-HSD1 did not appear to vary across the two groups.
|
28932959 |
2017 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
11β-HSDs were detectable in human skin SCCs and melanoma.
|
28797028 |
2017 |
|
Mucocutaneous Lymph Node Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GR and 11β-HSD expression changes in the acute phase of KD are important factors for regulating inflammatory responses in KD.
|
28567088 |
2017 |
|
Septicemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
As part of the AME evidence series on sepsis, we conducted a systematic review of all randomized controlled EGDT trials.
|
28275488 |
2017 |
|
Sepsis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
As part of the AME evidence series on sepsis, we conducted a systematic review of all randomized controlled EGDT trials.
|
28275488 |
2017 |
|
Metabolic symptoms
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Selective inhibition of 11β-HSD2 is generally detrimental to health because the accumulation of cortisol can cause metabolic symptoms such as apparent mineralocorticoid excess (AME), fetal developmental defects and lower testosterone levels in males.
|
28366868 |
2017 |