HSF1, heat shock transcription factor 1, 3297

N. diseases: 185; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.250 AlteredExpression disease BEFREE For example, in neurodegenerative disorders such as Huntington's disease and Alzheimer's disease the expression levels of the monomeric HSF1 are found to be reduced markedly. 29341886 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.250 Biomarker disease BEFREE Further, the formation of neuronal aggregates is also influenced by HSP90 inhibitors and provides protection from toxicity of protein through HSF-1 activation and HSP70 induction in AD. 28758577 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.250 Biomarker disease BEFREE We will discuss what is known of the mechanisms of HSF1 regulation in regard to the HSP dysregulation seen in in AD and cancer. 28484363 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.250 Biomarker disease BEFREE Alleviation of ER stress and enhancement of heat shock response through heat shock factor 1 (HSF1) activation have previously been considered as attractive potential therapeutic targets for Alzheimer's disease (AD)-a prevalent and devastating tauopathy. 28678786 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.250 Biomarker disease BEFREE The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice. 24849358 2014
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.250 Biomarker disease RGD Even more interesting, injection of lentivirus vector-HSF1 into the cerebella of AD rats significantly increased HSF1 and HSP expression levels and induced an increase in the number of Purkinje cell bodies. 23665061 2013