|
Atrial Fibrillation
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
RP11 - 99E15.2 and RP3 - 523K23.2 may participate in the pathogenesis of AF via regulating the extracellular matrix binding and the transcription of HSF2 target genes, respectively.
|
31680326 |
2019 |
|
Acute Erythroblastic Leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
HSF2 has been thought to be responsible for accumulation of HSP70 during hemin-induced differentiation of human K562 erythroleukemia cells because of accompanying acquisition of HSF2 DNA binding activity.
|
9738016 |
1998 |
|
Acute Erythroblastic Leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Heat shock factor 2 (HSF2) acquires DNA binding activity during hemin-induced differentiation of human K562 erythroleukemia cells.
|
9367915 |
1997 |
|
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, we found that DOX induced mitochondrial ROS release to activate ERK-mediated HSF2 nuclear translocation and AT<sub>1</sub> R upregulation causing DOX-damaged heart failure in vitro and in vivo.
|
28295305 |
2018 |
|
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we found that heat shock transcription factor 2 (HSF2) activated IGF-IIR to induce cardiac hypertrophy for hypertension-induced heart failure.
|
29180262 |
2018 |
|
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we found that heat shock transcription factor 2 (HSF2) activated IGF-IIR to induce cardiac hypertrophy for hypertension-induced heart failure.
|
29180262 |
2018 |
|
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, we found that DOX induced mitochondrial ROS release to activate ERK-mediated HSF2 nuclear translocation and AT<sub>1</sub> R upregulation causing DOX-damaged heart failure in vitro and in vivo.
|
28295305 |
2018 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
This study provides the first evidence for HSF2 acting as a suppressor of invasion in human malignancies.
|
26119944 |
2016 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Silencing ALG3 or HSF2 inhibited the proliferation, migration, and invasion abilities of MCF-7 cells.
|
29799832 |
2018 |
|
Adult Erythroleukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Heat shock factor 2 (HSF2) acquires DNA binding activity during hemin-induced differentiation of human K562 erythroleukemia cells.
|
9367915 |
1997 |
|
Adult Erythroleukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
HSF2 has been thought to be responsible for accumulation of HSP70 during hemin-induced differentiation of human K562 erythroleukemia cells because of accompanying acquisition of HSF2 DNA binding activity.
|
9738016 |
1998 |
|
Erythroleukemia (Erythroid/Myeloid)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Heat shock factor 2 (HSF2) acquires DNA binding activity during hemin-induced differentiation of human K562 erythroleukemia cells.
|
9367915 |
1997 |
|
Erythroleukemia (Erythroid/Myeloid)
|
0.020 |
Biomarker
|
disease |
BEFREE |
HSF2 has been thought to be responsible for accumulation of HSP70 during hemin-induced differentiation of human K562 erythroleukemia cells because of accompanying acquisition of HSF2 DNA binding activity.
|
9738016 |
1998 |
|
Azoospermia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A dominant-negative mutation of HSF2 associated with idiopathic azoospermia.
|
23064888 |
2013 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
This study provides the first evidence for HSF2 acting as a suppressor of invasion in human malignancies.
|
26119944 |
2016 |
|
Ulcerative Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HSF2 was differentially expressed in UC patients compared to normal controls.
|
24533153 |
2014 |
|
Crohn Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of heat shock factor 2(HSF2)in colonic mucosa in Crohn's disease, Behcet's disease, ulcerative colitis, intestinal tuberculosis, infective enteritis, intestinal lymphoma, and normal controls was investigated by immunohistochemistry (IHC).
|
24533153 |
2014 |
|
Male infertility
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Cooperation of HSF1 and HSF2 is especially well established since their double knockout results in meiosis arrest, spermatocyte apoptosis, and male infertility.
|
28389750 |
2017 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Importantly, low HSF2 expression correlates with high Gleason score, metastasis and poor survival of PrCa patients, highlighting the clinical relevance of our findings.
|
26119944 |
2016 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In depth mechanism analysis demonstrated that HSF2 promoted cell proliferation via positive regulation of aerobic glycolysis, and HSF2 interacted with euchromatic histone lysine methyltransferase 2 (EHMT2) to epigenetically silence fructose-bisphosphatase 1 (FBP1), which is a tumor suppressor and negative regulator of aerobic glycolysis in HCC.
|
31497345 |
2019 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Gene expression profiling together with functional studies demonstrated that the molecular mechanism underlying the effect on tumor progression originates from HSF2 steering the switch between acinar morphogenesis and invasion.
|
26119944 |
2016 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, the study was expanded beyond PrCa, revealing that the expression of HSF2 is decreased in a wide range of cancer types.
|
26119944 |
2016 |
|
Thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
E2F, HSF2, and miR-26 in thyroid carcinoma: bioinformatic analysis of RNA-sequencing data.
|
26985959 |
2016 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, the study was expanded beyond PrCa, revealing that the expression of HSF2 is decreased in a wide range of cancer types.
|
26119944 |
2016 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HSF2 activated ALG3 and promoted the growth of breast carcinoma.
|
29799832 |
2018 |