|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Direct visualization using dual-color FISH on samples serves as a molecular tool for management of MALT-type lymphoma with API2/MLT gene fusion.
|
11763310 |
2001 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The translocation of chromosome 11, long arm, region 2, band 1, to chromosome 18, long arm, region 2, band 1 (t(11;18)(q21;q21)) represents a recurrent chromosomal abnormality in extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT) type and leads to a fusion of the apoptosis inhibitor-2 (API2) gene on chromosome 11 and the MALT lymphoma-associated translocation (MLT) gene on chromosome 18.
|
10979968 |
2000 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To gain some insight into the mechanism that generates this translocation, we cloned and sequenced an API2-MALT1 fused transcript as well as genomic DNA of the t(11;18) translocation from a MALT lymphoma.
|
11162514 |
2001 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Pulmonary mucosa-associated lymphoid tissue lymphoma is unique in that chronic inflammation is rare and that API2-MALT1 fusion, resulting from t(11;18)(q21;q21), occurs frequently.
|
21396678 |
2011 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A t(11;18)(q21;q21) involving API2 and MALT1 occurs in a subset of MALT lymphomas but with only rare exception is absent in diffuse large B-cell lymphomas (DLBCL), even at MALT sites.
|
14652825 |
2003 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The most frequent chromosome translocation associated with MALT lymphoma is t(11;18)(q21;q21), which generates a chimeric protein of c-IAP2 and MALT1/paracaspase.
|
15894263 |
2005 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The t(11;18)(q21;q21) API2/MALT1 translocation is a specific chromosomal abnormality in extranodal marginal B-cell lymphomas of the mucosa-associated lymphoid tissue (MALT) type, particularly in those occurring in the stomach and lungs.
|
17153776 |
2006 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to clarify predictive factors for response to eradication therapy in cases of Helicobacter pylori (H. pylori)-positive API2-MALT1-negative gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
|
19385974 |
2009 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gastric MALT lymphomas are divided into three groups based on responsiveness to Helicobacter Pylori eradication and detection of API2-MALT1 fusion.
|
15577674 |
2004 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, the RT-PCR assay used here should serve as an effective molecular tool for understanding molecular pathogenesis and the clinical significance of API2-MALT1 for MALT lymphomas.
|
10702396 |
2000 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The recently discovered MLT/MALT1 gene is fused with the API2 gene in the t(11;18)(q21;q21), which characterizes about one-third of MALT lymphomas.
|
12931213 |
2003 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We therefore screened 51 cases of pulmonary MALT lymphoma for API2-MALT1 fusion, and studied its relationship with clinicopathologic factors including the immunohistochemical expression of BCL10, another MALT lymphoma-associated molecule.
|
12651604 |
2003 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
T(11;18)(q21;q21) is the most common structural abnormality in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) leading to the fusion of the apoptosis inhibitor-2 (API2) gene and the MALT lymphoma-associated translocation (MALT1) gene.
|
12406890 |
2003 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
As a result, the reciprocal transcript was not present, strongly suggesting that the API2-MLT fusion is involved in the oncogenesis of MALT lymphoma.
|
10339464 |
1999 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Similarly, the three MALT lymphoma associated chromosome translocations, namely t(1;14)(p22;q32)/BCL10-IGH, t(14;18)(q32;q21)/IGH-MALT1,and t(11;18)(q21;q21)/BIRC3 (API2)-MALT1, are also capable of activating both canonical and non-canonical NF-κB pathways.
|
27452667 |
2016 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
RT-PCR analysis revealed that 17 of the 95 (17.9%) MALT lymphomas but none of the nine nMZBCLs or 16 DLBLs had API2-MALT1 fusion transcripts.
|
11736940 |
2001 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We recently demonstrated that API2-MALT1 can induce transactivation of the API2 gene through NF-kappaB activation, thus highlighting a positive feedback-loop mechanism of self-activation by upregulating its own expression in t(11;18) MALT lymphomas.
|
16572204 |
2006 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Significantly, 98% of all cIAP2-MALT1 fusion proteins retain the UBA domain, suggesting that ubiquitin-binding contributes to the oncogenic potential of cIAP2-MALT1 in MALT lymphoma.
|
18931663 |
2008 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The detection of API2-MALT1 fusion as carried out with these specimens would be useful as an ancillary assay for the diagnosis, staging, and follow-up of pulmonary MALT lymphoma.
|
16105761 |
2005 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Approximately 10% of gastric low-grade B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type are unresponsive to Helicobacter pylori ( H. pylori) eradication treatment, and many of them contain an API2-MALT1 chimeric transcript mediated by t(11;18)(q21;q21) translocation.
|
14614598 |
2003 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The lung was the preferential anatomical site of origin of MALT lymphomas harboring API2-MALT1 fusion.
|
11159207 |
2001 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Aberrant nuclear BCL10 expression may be closely correlated with API2-MALT1 fusion in gastric and pulmonary MALT lymphomas.
|
12883238 |
2003 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, these data support the hypothesis that the API2-MALT1 fusion protein can contribute to MALT lymphoma formation via increased NF-kappaB activation.
|
16707452 |
2006 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
API2-MALT1 fusion genes were detected in seven cases (15%) of MALT lymphoma and one case (8%) of diffuse large B-cell lymphoma.
|
14681324 |
2003 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polypoid lesions in MALT-C were associated with c-IAP2-MALT1 / MLT gene alteration resulting from t(11;18)(q21;q21).
|
10760689 |
2000 |