Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.340 GeneticVariation disease BEFREE Association Studies of HSPA1A and HSPA1L Gene Polymorphisms With Schizophrenia. 30342847 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.340 Biomarker disease PSYGENET In this study, we analyzed the potential implication of HSPA1A +190G/C, HSPA1B +1267A/G, and HSPA1L +2437T/C polymorphisms in the susceptibility to paranoid schizophrenia in a homogenous Caucasian Polish population. 23893339 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.340 Biomarker disease PSYGENET We previously investigated a group of single-nucleotide polymorphisms of a set of genes coding for heat shock proteins (HSPA1A, HSPA1B and HSPA1L) and found a significant association between one HSPA1B variation and schizophrenia (SZ). 19439993 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.340 GeneticVariation disease BEFREE We previously investigated a group of single-nucleotide polymorphisms of a set of genes coding for heat shock proteins (HSPA1A, HSPA1B and HSPA1L) and found a significant association between one HSPA1B variation and schizophrenia (SZ). 19439993 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.340 Biomarker disease BEFREE Association between the three polymorphisms of HSP70-1 (HSPA1A), HSP70-hom (HSPA1L) and HSP70-2 (HSPA1B) and schizophrenia has been reported. 18299791 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.340 Biomarker disease PSYGENET Association between the three polymorphisms of HSP70-1 (HSPA1A), HSP70-hom (HSPA1L) and HSP70-2 (HSPA1B) and schizophrenia has been reported. 18299791 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.340 Biomarker disease BEFREE This study aimed to investigate the association between the three polymorphisms of HSP70-1 (HSPA1A), HSP70-hom (HSPA1L) and HSP70-2 (HSPA1B) and schizophrenia. 15963589 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.340 Biomarker disease PSYGENET There were no significant differences in the allelic or genotype frequencies of the HSPA1A and HSPA1L polymorphisms between the schizophrenia patients and the controls, while there was a marginal difference in the genotype frequency of the HSPA1B polymorphisms, and a significant difference in the allelic frequency of the HSPA1B polymorphisms between the schizophrenia patients and the controls. 15963589 2005
CUI: C0036349
Disease: Paranoid Schizophrenia
Paranoid Schizophrenia
0.320 GeneticVariation disease BEFREE The present study aimed to determine whether genetic variants in the HSPA1A (rs1008438, rs562047) and HSPA1L (rs2075800) genes are associated with the risk of paranoid schizophrenia and the clinical presentation of the disease. 30342847 2018
CUI: C0036349
Disease: Paranoid Schizophrenia
Paranoid Schizophrenia
0.320 GeneticVariation disease BEFREE In this study, we analyzed the potential implication of HSPA1A +190G/C, HSPA1B +1267A/G, and HSPA1L +2437T/C polymorphisms in the susceptibility to paranoid schizophrenia in a homogenous Caucasian Polish population. 23893339 2014
CUI: C0024517
Disease: Major depression, single episode
Major depression, single episode
0.300 Biomarker disease PSYGENET One hundred and forty two hospitalised patients, affected by major depression and treated with antidepressants drugs for a major depressive episode were evaluated for depressive severity at the baseline and at the discharge and genotyped for five SNPs within the genes HSPA1L, HSPA1A and HSPA1B. 17428599 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.300 Biomarker disease PSYGENET One hundred and forty two hospitalised patients, affected by major depression and treated with antidepressants drugs for a major depressive episode were evaluated for depressive severity at the baseline and at the discharge and genotyped for five SNPs within the genes HSPA1L, HSPA1A and HSPA1B. 17428599 2007
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.300 Biomarker disease PSYGENET One hundred and forty two hospitalised patients, affected by major depression and treated with antidepressants drugs for a major depressive episode were evaluated for depressive severity at the baseline and at the discharge and genotyped for five SNPs within the genes HSPA1L, HSPA1A and HSPA1B. 17428599 2007
CUI: C0013182
Disease: Drug Allergy
Drug Allergy
0.300 Biomarker group CTD_human Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. 16538175 2006
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.120 GeneticVariation disease BEFREE We reported a strong association between rs2227956 polymorphism and MS risk, which is independent from the association with HSP70-2 rs1061581, and a significant link between hsp70-hom protein expression and MS severity. 27609295 2016
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.120 GeneticVariation disease GWASDB Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. 20598377 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.120 Biomarker disease BEFREE Despite the strength of the association of multiple sclerosis (MS) and human leukocyte antigen (HLA)-DR2, other genetic elements could have a role in the pathophysiology of MS. We investigated possible associations with polymorphic susceptibility genes located within the HLA complex, i.e., heat-shock protein (HSP)70-1, HSP70-2, and HSP70-hom in Japanese patients with MS. 11696222 2001
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease
0.110 GeneticVariation disease BEFREE There was no evidence for the association of hsp70-hom (+2437T/C), TNF-α (+489G/A) SNPs and HMOX-1 (number of GT repeats) polymorphism with COPD. 22542718 2012
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.110 GeneticVariation disease GWASDB A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. 21156761 2011
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.110 GeneticVariation disease GWASDB REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. 19503088 2009
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.110 GeneticVariation disease GWASDB TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. 17804836 2007
Diabetes Mellitus, Insulin-Dependent
0.110 GeneticVariation disease GWASDB A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. 17632545 2007
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.110 GeneticVariation disease BEFREE Analysis of 60 rheumatoid arthritis (RA) families, each with an affected sib-pair, revealed an association between hsp70-hom A-2763 and RA using both the transmission disequilibrium test (TDT) and the transmission to sib-pair (Tsp) test (P=0.0038 and P=0.013, respectively). 10958354 2000
Diabetes Mellitus, Insulin-Dependent
0.110 Biomarker disease BEFREE Polymorphic analysis of the human MHC-linked heat shock protein 70 (HSP70-2) and HSP70-Hom genes in insulin-dependent diabetes mellitus (IDDM). 7901896 1993
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease
0.110 GeneticVariation disease CLINVAR