|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HSP70, which is frequently overexpressed in prostate cancer (PCa), has been shown to critically contribute to tumor cell survival, and might therefore represent a potential therapeutic target.
|
31222811 |
2020 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High serum anti-HSPA4 IgG was correlated with high tumor HSPA4 expression and poor prognosis of breast cancer subjects.
|
30643287 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Future studies with larger patient cohorts and well-defined tumor sizes are necessary to elucidate the role of serum Hsp70 as a biomarker for tumor detection and monitoring of outcome in pet animals.
|
31375996 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Herein, quercetin is not only the heat shock protein (Hsp 70) inhibitor but also the skeleton of Qu-Fe<sup>II</sup>P, realizing near-infrared light induced low-temperature PTT (45 °C) to ablate tumor completely without heat stress to normal tissues.
|
31228705 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have used tumor differentiation factor protein/peptide as ligand and Hsp70/Hsp90 as receptor protein as examples to study ligand-protein interaction.
|
31347053 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Molecular constructs containing recombinant mini-antibodies specific to tumor-associated antigens (in particular, antibodies specific to HER2/neu-antigen and other markers highly expressed on the surface of a wide range of cancer cells) can be used to target the delivery of HSP70 to tumor tissues.
|
30397532 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In preclinical studies with model animals, intravenous administration of a derivative of chemokine CCL3, named eMIP, after local electron-beam irradiation, not only enhanced tumor growth inhibition at a target site but also induced tumor killing beyond the treated site (a phenomenon known as the abscopal effect). eMIP works with alarmins such as high mobility group box 1 (HMGB1) and heat shock protein 70 (HSP70) released from overexpressed tumor cells by irradiation.
|
31058025 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Upregulation of HSP70 induces tumor development, however, the molecular mechanism of HSP70 in ALL remains unclear.
|
31521893 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Under non-stress conditions, Hsp70 and Gb3 are structurally clustered in the membrane of TNTs of tumor cells that showed tumor type specific variations in the amount of cell-to-cell connection networks.
|
30632067 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The adverse prognostic value of a high Hsp70 expression for OS was also observed in patient cohorts with p16- (p = 0.001), p53- (p = 0.0003) and HPV16 DNA-negative (p = 0.001) tumors.
|
29235112 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HSP70 protein expression, tumor diameter, and tumor volume were lower in the CR group than in the PR group.
|
29023986 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Membrane Hsp70-A Novel Target for the Isolation of Circulating Tumor Cells After Epithelial-to-Mesenchymal Transition.
|
30443493 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The ability of our chemically optimized peptide-based tracer TPP-PEG<sub>24</sub>-DFO[<sup>89</sup>Zr] to detect mHsp70 <i>in vivo</i> suggests its broad applicability in targeting and imaging with high specificity for any tumor type that exhibits surface expression of Hsp70.<b>Significance:</b> A novel peptide-based PET tracer against the oligomerization domain of Hsp70 has potential for universal tumor-specific imaging <i>in vivo</i> across many tumor type.<i></i>.
|
30228173 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A membrane HSP70-positive tumour phenotype is associated with aggressiveness and therapy resistance, but also serves as a recognition structure for targeted therapies.
|
29203711 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Selection of an Anticalin® against the membrane form of Hsp70 via bacterial surface display and its theranostic application in tumour models.
|
29140786 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No clear pattern emerged for Hsp70/Hsp90 expression along the breast neoplasia continuum.
|
29491085 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
While both pNGVL4a-Sig/E7(detox)/HSP70 DNA vaccine and TA-HPV recombinant vaccinia viral vector-based vaccines have elicited HPV-specific CD8+ T cell responses in HPV16/E7-expressing tumor models, and been used as prime-boost regimen to enhance HPV-specific immune responses in humans (NCT00788164), the optimal route of administration for TA-HPV remains unclear.
|
30296681 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Depletion or inhibition of Hsp70 frequently reduces the size of the tumors and can even cause their complete involution.
|
29177673 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In order to elucidate the role of intracellular and membrane-bound Hsp70 as a potential tumor biomarker in glioblastoma multiforme, herein, we describe protocols for the staining of cytosolic Hsp70 in tumor formalin fixed paraffin-embedded (FFPE) sections using immunohistochemistry, and for plasma membrane-bound Hsp70 by multi-parametric flow cytometry using the cmHsp70.1 monoclonal antibody (mAb).
|
29177668 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Heat shock protein 70 (Hsp70) and Hsp90 are molecular chaperones that play essential roles in tumor growth by stabilizing pro-survival client proteins.
|
29255093 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Gas‑filled ultrasound microbubbles enhance the immunoactivity of the HSP70‑MAGEA1 fusion protein against MAGEA1‑expressing tumours.
|
29749485 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The Hsp70 stress molecule on the surface of the tumor cells is used as a recognition target, while the Tag7 protein on the lymphocyte membrane acts as a receptor for Hsp70.
|
29850628 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HSP70 played an important role in the pathogenesis of cancer which stabilized the production of large amount of oncogenic proteins and finally supported growth and survival of tumor.
|
30245753 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, the mechanism studies also demonstrate that Bi<sub>2</sub> S<sub>3</sub> -Tween 20@LY294002 potently kills LoVo cancer cells under low-power near-infrared light irradiation, by downregulating the expression of heat shock protein 70 (HSP70) so as to increase the sensitivity of tumor cell hyperthermia and activating BAX/BAK-regulated mitochondrial apoptosis pathway.
|
30240165 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cytotoxic Tag7-Hsp70 complex is secreted by lymphocytes after interaction with the HLA-negative tumors.
|
27868339 |
2017 |