Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0016085
Disease: Filariasis
Filariasis
0.010 Biomarker disease BEFREE ELISA with a purified beta-galactosidase fusion protein from B. pahangi showed antibody responses to hsc70 across the clinical spectrum of filariasis. 2659668 1989
CUI: C0392663
Disease: Infection by Wuchereria bancrofti
Infection by Wuchereria bancrofti
0.010 Biomarker disease BEFREE However, ELISA with recombinant fusion proteins for both Plasmodium falciparum and Schistosoma mansoni hsc70 indicated that some individuals with Brugian or Bancroftian filariasis did produce antibodies which cross-reacted with plasmodial and schistosomal homologs. 2659668 1989
CUI: C0024302
Disease: Reticulosarcoma
Reticulosarcoma
0.010 AlteredExpression disease BEFREE Regulation of hsc70 expression in the human histiocytic lymphoma cell line, U937. 8033225 1993
CUI: C0079744
Disease: Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma
0.010 AlteredExpression disease BEFREE Regulation of hsc70 expression in the human histiocytic lymphoma cell line, U937. 8033225 1993
CUI: C0334663
Disease: Histiocytic sarcoma
Histiocytic sarcoma
0.010 AlteredExpression disease BEFREE Regulation of hsc70 expression in the human histiocytic lymphoma cell line, U937. 8033225 1993
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.030 AlteredExpression group BEFREE cis-acting elements involved in transcriptional regulation of the herpes simplex virus type 1 latency-associated promoter 1 (LAP1) in vitro and in vivo. 8764049 1996
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.010 Biomarker group BEFREE Identification and characterization of a novel hsc70-like gene in the human lung tumor cell line HS24. 9115634 1997
CUI: C0025202
Disease: melanoma
melanoma
0.030 AlteredExpression disease BEFREE These data indicate that HSC71 molecules are expressed on human melanoma cell line P36, and that HSC71 may play a potential role in Ag presentation and processing of T. gondii-infected P36 cells to CD4+ CTL. 9272701 1997
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker disease RGD Assembly of proteins to postsynaptic densities after transient cerebral ischemia. 9425004 1998
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease
0.200 Biomarker disease RGD Expression of 70-kDa heat-shock protein during acute graft-versus-host disease. 9557158 1998
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury
0.300 Therapeutic disease CTD_human Heat-shock protein-73 protects against small intestinal warm ischemia-reperfusion injury in the rat. 10216529 1999
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases
0.210 Biomarker group RGD Our findings demonstrated that HSP73 and HSP90 chaperone proteins specifically accumulated within lysosomes of proximal tubular epithelial cells during the course of PDGA-induced acute lysosomal thesaurismosis. 10469394 1999
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.070 GeneticVariation disease BEFREE In both cases, mutation was coincident with allelic imbalance, suggesting that HSC70 is a target of somatic mutation and deletion in a fraction of breast carcinomas. 10485459 1999
CUI: C3178817
Disease: Paraneoplastic Syndromes, Ocular
Paraneoplastic Syndromes, Ocular
0.200 Biomarker disease RGD Cancer-associated retinopathy induced by both anti-recoverin and anti-hsc70 antibodies in vivo. 10586938 1999
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.020 AlteredExpression disease BEFREE Furthermore, this is the first study demonstrating the expression of NIP(71) in human colon cancer cell lines and a possible relationship to colon carcinogenesis. 10891381 2000
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.020 AlteredExpression disease BEFREE Furthermore, this is the first study demonstrating the expression of NIP(71) in human colon cancer cell lines and a possible relationship to colon carcinogenesis. 10891381 2000
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 AlteredExpression phenotype BEFREE Furthermore, this is the first study demonstrating the expression of NIP(71) in human colon cancer cell lines and a possible relationship to colon carcinogenesis. 10891381 2000
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.020 GeneticVariation disease BEFREE Quantitative precipitation assay from total cellular proteins and from lysosomal extracts demonstrated that RA-associated HLA-DRB1 alleles bound Hsp73 better than did HLA-DRB1 alleles that were not associated with RA. 11953969 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE HSC70 was also detected in the majority (97%) of cases, although expression was not correlated with BAG-1 levels, oestrogen receptor status or tumour grade. 12081204 2002
CUI: C0853879
Disease: Invasive carcinoma of breast
Invasive carcinoma of breast
0.010 AlteredExpression disease BEFREE Immunohistochemistry was used to examine the expression of BAG-1 and HSC70 in 160 cases of invasive breast cancer. 12081204 2002
Chemical and Drug Induced Liver Injury
0.200 Biomarker disease RGD Immunohistochemical studies on the expression pattern of molecular chaperones HSC70 and HSP25 and cell cycle-related proteins cyclin D1 and PCNA in rat liver after thioacetamide intoxication. 12376827 2002
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.010 Biomarker disease BEFREE We have investigated the association of genetic polymorphisms of the constitutive HSP70 (HSP73) and the inducible HSP70 (HSP72) encoding genes with the risk of acute renal failure (ARF) in very low birth weight (VLBW) neonates. 12840151 2003
CUI: C0282666
Disease: Very Low Birth Weight
Very Low Birth Weight
0.010 Biomarker phenotype BEFREE We have investigated the association of genetic polymorphisms of the constitutive HSP70 (HSP73) and the inducible HSP70 (HSP72) encoding genes with the risk of acute renal failure (ARF) in very low birth weight (VLBW) neonates. 12840151 2003
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.020 Biomarker disease BEFREE We demonstrated in this study that the HSC70 gene encodes two antigenic peptides recognised by HLA-B46-restricted and tumour-reactive CTLs established from tumour-infiltrating lymphocytes of a colon cancer. 12966429 2003
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.020 Biomarker disease BEFREE We demonstrated in this study that the HSC70 gene encodes two antigenic peptides recognised by HLA-B46-restricted and tumour-reactive CTLs established from tumour-infiltrating lymphocytes of a colon cancer. 12966429 2003