|
Acute Coronary Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
"Proteomic changes related to ""bewildered"" circulating platelets in the acute coronary syndrome."
|
21751358 |
2011 |
|
Noninfiltrating Intraductal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
344 specific genes, such as FN1, AURKA and HSPA8, were found to be significantly changed (both upregulated and downregulated) in DCIS group in comparison with normal tissue group, which represents the gene profile changes in early stage of breast cancer development.
|
27506314 |
2016 |
|
Acute kidney injury
|
0.200 |
Biomarker
|
disease |
RGD |
73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin.
|
14966137 |
2004 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Tumors with weak (+) HSC70 protein staining were more frequent in the carriers of the polymorphic 1541-1542delGT allele than in the homozygotes of the major allele (20% vs. 6%, P=0.05 by Fisher's exact test).
|
14991745 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HSC70 was also detected in the majority (97%) of cases, although expression was not correlated with BAG-1 levels, oestrogen receptor status or tumour grade.
|
12081204 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Hsc70 down-regulation might reflect a functional integration of the overexpressed Hsp70 on the basis of a chaperone network so that only acute induction will provide Hsp70 that can improve tumor cell lysability.
|
14678977 |
2003 |
|
melanoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
HSP73 immunostaining was stronger in melanoma metastases when compared with acquired melanocytic nevi which was statistically significant.
|
15254721 |
2004 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
HSP73 immunostaining was stronger in melanoma metastases when compared with acquired melanocytic nevi which was statistically significant.
|
15254721 |
2004 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
HSP73 immunostaining was stronger in melanoma metastases when compared with acquired melanocytic nevi which was statistically significant.
|
15254721 |
2004 |
|
Melanocytic nevus
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSP73 immunostaining was stronger in melanoma metastases when compared with acquired melanocytic nevi which was statistically significant.
|
15254721 |
2004 |
|
Melanocytic nevus of skin
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSP73 immunostaining was stronger in melanoma metastases when compared with acquired melanocytic nevi which was statistically significant.
|
15254721 |
2004 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Hsc70 appears active in human breast cancer cells and hypersecreted by direct cath D inhibition.
|
19802014 |
2010 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Hsc70 appears active in human breast cancer cells and hypersecreted by direct cath D inhibition.
|
19802014 |
2010 |
|
Hepatitis B
|
0.020 |
Biomarker
|
disease |
BEFREE |
Hsc70 has been found to be required for HBV DNA replication.
|
23158906 |
2012 |
|
Dystonia
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
LAP1 interacts with torsinA, the protein mutated in DYT1-dystonia.
|
25425325 |
2014 |
|
Dystonia Disorders
|
0.040 |
GeneticVariation
|
group |
BEFREE |
LAP1 interacts with torsinA, the protein mutated in DYT1-dystonia.
|
25425325 |
2014 |
|
Adult Extraskeletal Myxoid Chondrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma.
|
28383167 |
2017 |
|
Dehydration
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
HSC70 increased in the liver and kidneys (1.20-1.36-fold), but decreased in skeletal muscle (0.27-0.55 of control) during dehydration.
|
28676984 |
2018 |
|
Enterovirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Hsc70 regulates the IRES activity and serves as an antiviral target of enterovirus A71 infection.
|
29180285 |
2018 |
|
Virus Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Hsc70-2 is required for Beet black scorch virus infection through interaction with replication and capsid proteins.
|
29540800 |
2018 |
|
Cholera
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSC70 and HSP90 chaperones perform complementary roles in translocation of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol.
|
31221799 |
2019 |
|
Cervical Squamous Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A differential protein pattern for SCC was, e.g. over-expressed (OE) eukaryotic translation initiation factor 3-2β, neutrophil cytosolic factor 2, annexin A6 (ANXA6), for SVC it was OE cathepsin D, γ-catenin, RAB2A, for both cancers it was OE apolipoprotein E, tropomyosin 3, HSPA8, and underexpressed cytokeratin 13, osteoglycin.
|
21137014 |
2010 |
|
Alzheimer's Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
A significant downregulation of HSPA8 and HSPA9 was observed in AD across the three brain regions compared to the controls, suggesting their participation in AD pathogenesis.
|
23948933 |
2014 |
|
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Abbreviations: 3-MA: 3-methyladenine; AR7: 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine; CMA: chaperone-mediated autophagy; CQ: chloroquine; CSF: cerebrospinal fluid; DDM: n-dodecyl β-D-maltoside; DIV: days in vitro; ELISA: enzyme-linked immunosorbent assay; FACS: fluorescence-activated cell sorting; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GWAS: genome-wide association studies; HSPA8/HSC70: heat shock protein 8; KFERQ: CMA recognition pentapeptide; KI: knockin; LAMP1: lysosomal-associated membrane protein 1; LAMP2A: lysosomal-associated membrane protein 2A; LDH: lactate dehydrogenase; LRRK2: leucine-rich repeat kinase 2; MEF: mouse embryonic fibroblast; NDUFS4: NADH:ubiquinone oxidoreductase core subunit S4; NE: novel epitope; PD: Parkinson disease; RARA/RARα: retinoic acid receptor, alpha; SNCA: synuclein, alpha; TUBB3/TUJ1: tubulin, beta 3 class III; WT: wild-type.
|
30983487 |
2020 |
|
Parkinson Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Act5C: actin 5C; a.E.: after eclosion; Atg5: autophagy-related 5; Atg8a/LC3: autophagy-related 8a; CMA: chaperone-mediated autophagy; DHE: dihydroethidium; elav: embryonic lethal abnormal vision; eMI: endosomal microautophagy; ESCRT: endosomal sorting complexes required for transport; GABARAP: GABA typeA receptor-associated protein; Hsc70-4: heat shock protein cognate 4; HSPA8/Hsc70: heat shock protein family A (Hsp70) member 8; LAMP2: lysosomal associated membrane protein 2; MDA: malondialdehyde; PA-mCherry: photoactivable mCherry; PBS: phosphate-buffered saline; PCR: polymerase chain reaction; PD: Parkinson disease; Ref(2)P/p62: refractory to sigma P; ROS: reactive oxygen species; RpL32/rp49: ribosomal protein L32; RT-PCR: reverse transcription polymerase chain reaction; SING: startle-induced negative geotaxis; SNCA/α-synuclein: synuclein alpha; SQSTM1/p62: sequestosome 1; TBS: Tris-buffered saline; UAS: upstream activating sequence.
|
29989488 |
2018 |