Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1837522
Disease: Impaired pain sensation
Impaired pain sensation 		0.100 Biomarker phenotype HPO
CUI: C1847584
Disease: Distal sensory impairment
Distal sensory impairment 		0.100 Biomarker phenotype HPO
CUI: C1848736
Disease: Distal amyotrophy
Distal amyotrophy 		0.100 Biomarker disease HPO
CUI: C1854494
Disease: Slow progression
Slow progression 		0.100 Biomarker phenotype HPO
CUI: C1854657
Disease: Limb fasciculations
Limb fasciculations 		0.100 Biomarker phenotype HPO
CUI: C1856694
Disease: Areflexia of lower limbs
Areflexia of lower limbs 		0.100 Biomarker phenotype HPO
CUI: C1858729
Disease: Decreased motor nerve conduction velocity
Decreased motor nerve conduction velocity 		0.100 Biomarker phenotype HPO
CUI: C1866141
Disease: Foot dorsiflexor weakness
Foot dorsiflexor weakness 		0.100 Biomarker phenotype HPO
CUI: C1866934
Disease: Reduced tendon reflexes
Reduced tendon reflexes 		0.100 Biomarker phenotype HPO
CUI: C4021222
Disease: Impaired temperature sensation
Impaired temperature sensation 		0.100 Biomarker disease HPO
CUI: C4021523
Disease: Upper limb amyotrophy
Upper limb amyotrophy 		0.100 Biomarker disease HPO
CUI: C4021578
Disease: Chronic axonal neuropathy
Chronic axonal neuropathy 		0.100 Biomarker disease HPO
CUI: C4021727
Disease: EMG: neuropathic changes
EMG: neuropathic changes 		0.100 Biomarker phenotype HPO
CUI: C4025614
Disease: EMG: chronic denervation signs
EMG: chronic denervation signs 		0.100 Biomarker phenotype HPO
CUI: C4025696
Disease: Paresis of extensor muscles of the big toe
Paresis of extensor muscles of the big toe 		0.100 Biomarker phenotype HPO
CUI: C4025799
Disease: Ulnar claw
Ulnar claw 		0.100 Biomarker disease HPO
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE 3) Suppressing HSP27 decreases tumor cell survival in all gliomas, but is more effective in SPARC-expressing tumor cells due to the removal of HSP27 inhibition of SPARC-induced pro-apoptotic signaling. 22480225 2012
CUI: C0270726
Disease: Alexander Disease
Alexander Disease 		0.030 Biomarker disease BEFREE Alexander disease (AxD) is a neurodegenerative disorder with prominent white matter degeneration and the presence of Rosenthal fibers containing aggregates of glial fibrillary acidic protein (GFAP), and small stress proteins HSP27 and αB-crystallin, and widespread reactive gliosis. 23594359 2014
CUI: C0007758
Disease: Cerebellar Ataxia
Cerebellar Ataxia 		0.110 Biomarker phenotype BEFREE Ataxia-Telangectasia Mutated-mediated DNA repair signaling was impaired in irradiated cells with Hsp27 knockdown. 23849696 2013
CUI: C0004134
Disease: Ataxia
Ataxia 		0.010 Biomarker phenotype BEFREE Ataxia-Telangectasia Mutated-mediated DNA repair signaling was impaired in irradiated cells with Hsp27 knockdown. 23849696 2013
CUI: C0007959
Disease: Charcot-Marie-Tooth Disease
Charcot-Marie-Tooth Disease 		0.200 GeneticVariation disease BEFREE Charcot-Marie-Tooth 2F: phenotypic presentation of the Arg136Leu HSP27 mutation in a multigenerational family. 25547330 2015
CUI: C0011175
Disease: Dehydration
Dehydration 		0.010 Biomarker phenotype BEFREE Dehydration increased HSP27 (1.45-1.65-fold) in the kidneys and lungs, and HSP40 (1.39-2.50-fold) in the liver, testes, and skeletal muscle. 28676984 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.100 Biomarker phenotype BEFREE Invasion and metastasis assays were used to determine the function of Hsp27 in CRC metastasis <i>in vitro</i> and <i>in vivo</i> using RNA interference and the ectopic expression of Hsp27. 30250600 2018
CUI: C0221228
Disease: Comedone
Comedone 		0.010 AlteredExpression disease BEFREE Comedo variants appeared to have somewhat higher hsp-27 expression than noncomedo DCIS, whether or not there was an associated IDC. 7530588 1995
CUI: C1332460
Disease: Barrett's Adenocarcinoma
Barrett's Adenocarcinoma 		0.010 Biomarker disease BEFREE Hsp27 protein was inducible by heat shock in Barrett's adenocarcinoma cell lines and an immortalized oesophageal epithelial cell line (HET-1A), but not by oestradiol. 10027336 1999