Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1854467
Disease: Spastic paraplegia 13, autosomal dominant
Spastic paraplegia 13, autosomal dominant 		0.920 Biomarker disease BEFREE Our findings suggest that Hsp60 defects can cause neurodegenerative pathologies of varying severity, not previously suspected on the basis of the SPG13 phenotype. 18571143 2008
CUI: C1854467
Disease: Spastic paraplegia 13, autosomal dominant
Spastic paraplegia 13, autosomal dominant 		0.920 GeneticVariation disease BEFREE We found that both the c.292G>A RNA transcript and the corresponding Hsp60-(p.Val98Ile) protein were present at comparable levels to their wild-type counterparts in SPG13 patient cells. 18378094 2008
CUI: C2677109
Disease: Leukodystrophy, Hypomyelinating, 4
Leukodystrophy, Hypomyelinating, 4 		0.730 Biomarker disease BEFREE The MitCHAP-60 disease is due to entropic destabilization of the human mitochondrial Hsp60 oligomer. 19706612 2009
CUI: C2677109
Disease: Leukodystrophy, Hypomyelinating, 4
Leukodystrophy, Hypomyelinating, 4 		0.730 GeneticVariation disease BEFREE This study constitutes a first finding concerning the relationship between disease-associated HSPD1 mutation and mitochondrial dynamics, which may be similar to the relationship between another disease-associated HSPD1 mutation (MitCHAP-60 disease) and aberrant mitochondrial dynamics. 25957474 2015
CUI: C2677109
Disease: Leukodystrophy, Hypomyelinating, 4
Leukodystrophy, Hypomyelinating, 4 		0.730 GeneticVariation disease BEFREE The patients were found to have a homozygous missense mutation in HSPD1, encoding the mitochondrial heat-shock protein 60 (Hsp60), and the disorder was defined as the autosomal recessive mitochondrial Hsp60 chaperonopathy (MitCHAP-60) disease. 27405012 2016
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.320 Biomarker disease BEFREE Human heat shock protein 60 (409-424) fragment is recognized by serum antibodies of patients with acute coronary syndromes. 12140130 2003
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.320 Biomarker disease BEFREE Heat-shock protein 60-reactive CD4+CD28null T cells in patients with acute coronary syndromes. 14993140 2004
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.310 Biomarker group BEFREE We conclude that with respect to early diagnosis of lung cancer that HSP60 and annexin-2 proteins are the important biomarkers in the subgroups of adenocarcinoma and squamous cell carcinoma. 28178129 2017
CUI: C0007194
Disease: Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 		0.310 Biomarker disease BEFREE The main findings were 1) several key PQC players were more abundant in HCM compared to controls, 2) after correction for sex and age, stabilizing heat shock protein (HSP)B1, and refolding, HSPD1 and HSPA2 were increased in HCM<sub>SMP</sub> compared to controls, 3) α-tubulin and acetylated α-tubulin levels were higher in HCM compared to controls, especially in HCM<sub>HI</sub>, 4) myosin-binding protein-C (cMyBP-C) levels were inversely correlated with α-tubulin, and 5) α-tubulin levels correlated with acetylated α-tubulin and HSPs. 31323898 2019
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.310 AlteredExpression disease BEFREE Furthermore, HSP60 overexpression was associated with a poor prognosis in patients with advanced gastric cancer in different risk groups. 25207654 2014
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.310 AlteredExpression disease BEFREE Here, we analyzed datasets in The Cancer Genome Atlas and revealed that higher HSP60 expression correlated with better overall survival in ccRCC patients. 31112866 2019
CUI: C0037773
Disease: Spastic Paraplegia, Hereditary
Spastic Paraplegia, Hereditary 		0.260 GeneticVariation disease BEFREE Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60. 11898127 2002
CUI: C0037773
Disease: Spastic Paraplegia, Hereditary
Spastic Paraplegia, Hereditary 		0.260 GeneticVariation disease BEFREE Mutations in the HSPD1 gene that encodes Hsp60 have been identified in patients with an autosomal dominant form of hereditary spastic paraplegia (SPG13), a late-onset neurodegenerative disorder characterized by a progressive paraparesis of the lower limbs. 18378094 2008
CUI: C0037773
Disease: Spastic Paraplegia, Hereditary
Spastic Paraplegia, Hereditary 		0.260 Biomarker disease BEFREE Sequence variants in SPAST, SPG3A and HSPD1 in hereditary spastic paraplegia. 19423133 2009
CUI: C0037773
Disease: Spastic Paraplegia, Hereditary
Spastic Paraplegia, Hereditary 		0.260 GeneticVariation disease BEFREE An hsp60 D3G mutation leads to MitCHAP-60, an early onset neurodegenerative disease while hsp60 V72I has been linked to SPG13, a form of hereditary spastic paraplegia. 31444388 2019
CUI: C0037773
Disease: Spastic Paraplegia, Hereditary
Spastic Paraplegia, Hereditary 		0.260 GeneticVariation disease BEFREE We have previously reported the association of a mutation (c.292G > A/p.V98I) in the human HSPD1 gene that encodes the mitochondrial Hsp60 chaperonin with a dominantly inherited form of hereditary spastic paraplegia. 18400758 2008
CUI: C0037773
Disease: Spastic Paraplegia, Hereditary
Spastic Paraplegia, Hereditary 		0.260 GeneticVariation disease BEFREE In the present work we have investigated 23 Danish index patients with hereditary spastic paraplegia (HSP) for mutations in the HSPD1 gene. 17420924 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.240 AlteredExpression disease BEFREE After adjustment for education subjects with AD showed significantly higher levels of Hsp60 than aMCI (OR = 1.16, 95% CI 1.04-1.30) and controls (OR = 1.12, 95% CI 1.03-1.22), while Hsp70 was significantly higher only in AD (OR = 1.84, 95% CI 1.09-3.10) than controls. 30584145 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.240 Biomarker disease BEFREE This review analyses the connection between AD and molecular chaperones, with particular attention toward the most important heat shock proteins (HSPs) as representative components of the human chaperome: Hsp60, Hsp70 and Hsp90. 30200516 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.240 GeneticVariation disease BEFREE We treated a mouse model of AD carrying the HLA-DR DRB1*1501 allele, with the Aβ B-cell epitope (Aβ 1-15) conjugated to the self-HSP60 peptide p458. 21473952 2011
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.240 Biomarker disease BEFREE HSP60 is important in mitochondrial function and defects in these organelles have been reported in DS and AD. 12515899 2002
CUI: C0243026
Disease: Sepsis
Sepsis 		0.230 AlteredExpression disease BEFREE Extracellular Hsp60 levels are significantly elevated in children with septic shock compared with both healthy controls and critically ill children without sepsis. 17588138 2007
CUI: C0243026
Disease: Sepsis
Sepsis 		0.230 Biomarker disease BEFREE We have repeatedly detected Candidatus Neoehrlichia mikurensis, a bacterium first described in Rattus norvegicus rats and Ixodes ovatus ticks in Japan in 2004 in the blood of a 61-year-old man with signs of septicemia by 16S rRNA and groEL gene PCR. 20587186 2010
CUI: C0243026
Disease: Sepsis
Sepsis 		0.230 AlteredExpression disease BEFREE Also, patients with BD showed lower levels of ccf nDNA (P = 0.04), HSP60 (P = 0.03), HSP70 (P = 0.01), and HSP90α (P = 0.002) as compared to patients with sepsis and higher levels of ccf mitochondrial DNA (P < 0.0001). 25891376 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.220 Biomarker group BEFREE Hypertension is also associated with B cell activation and production of autoantibodies (anti-Hsp70, anti-Hsp65, anti-Hsp60, anti-AT1R, anti-α1AR, and anti-β1AR). 31321561 2019