Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.080 Biomarker disease BEFREE CSF APLP1 was not different between any of the AD severity groups (p = 0.31). 31415236 2019
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.080 AlteredExpression disease BEFREE Taken together, the direct cleavage of APLP1 is a novel feature of the γ-secretase prompting a re-thinking of γ-secretase activity modulation as a therapeutic strategy for Alzheimer disease. 29382944 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.080 Biomarker disease BEFREE In conclusion, our results establish that APLPs show typical features of SAMs and indicate that increased surface expression, as observed for APLP1, is essential for proper synapse formation <i>in vitro</i> and synapse maintenance <i>in vivo</i><b>SIGNIFICANCE STATEMENT</b> According to the amyloid-cascade hypothesis, Alzheimer's disease is caused by the accumulation of Aβ peptides derived from sequential cleavage of the amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE1) and γ-secretase. 28450540 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.080 Biomarker disease BEFREE Consistently, knockdown or antagonization of DOR reduces secretase activities and ameliorates Abeta pathology and Abeta-dependent behavioral deficits, but does not affect the processing of Notch, N-cadherin or APLP in AD model mice. 20066010 2010
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.080 Biomarker disease BEFREE The amyloid precursor-like protein-1 (APLP1) is a member of a protein family that includes the Alzheimer's disease-associated amyloid precursor protein (APP). 19401174 2009
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.080 Biomarker disease BEFREE Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease. 15208260 2004
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.080 Biomarker disease BEFREE Our results suggest that even though APLP1 and APLP2 cannot generate Abeta, they may potentially contribute to the pathology of AD by generating peptide fragments whose toxicity is comparable to that of APPC31. 12124429 2002
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.080 Biomarker disease BEFREE Amyloid-precursor-like protein 1 (APLP1) is a membrane-associated glycoprotein, whose gene is homologous to the APP gene, which has been shown to be involved in the pathogenesis of Alzheimer's disease. 9521588 1998