APOA1, apolipoprotein A1, 335

N. diseases: 416; N. variants: 32
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4021780
Disease: Abnormality of the liver
Abnormality of the liver
0.100 Biomarker phenotype HPO
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.300 Biomarker disease CTD_human Genomics and the efficacy of aspirin in the treatment of cerebrovascular disease. 19433014 2009
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.020 Biomarker disease BEFREE Univariate analyses showed that gender, diabetes, Apolipoprotein A1 (ApoA1) and high-density lipoprotein cholesterol (HDL-c), and diagnosis of acute coronary syndrome (ACS) were associated with plaque vulnerability (P all < 0.05). 30984786 2019
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.020 AlteredExpression disease BEFREE Serum levels of ApoA-I (195 vs. 161.4mg/dL; P<.001) and ApoB (167 vs. 136.9mg/dL; P<.001) were significantly higher in CS compared with ACS; however, there was no genetic association. 28992985 2018
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.060 Biomarker disease BEFREE Non-Linear Relationship between Anti-Apolipoprotein A-1 IgGs and Cardiovascular Outcomes in Patients with Acute Coronary Syndromes. 31324073 2019
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.060 Biomarker disease BEFREE Univariate analyses showed that gender, diabetes, Apolipoprotein A1 (ApoA1) and high-density lipoprotein cholesterol (HDL-c), and diagnosis of acute coronary syndrome (ACS) were associated with plaque vulnerability (P all < 0.05). 30984786 2019
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.060 Biomarker disease LHGDN Prognostic utility of apoB/AI, total cholesterol/HDL, non-HDL cholesterol, or hs-CRP as predictors of clinical risk in patients receiving statin therapy after acute coronary syndromes: results from PROVE IT-TIMI 22. 19122170 2009
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.060 Biomarker disease BEFREE Recent evidence from a double-blind, randomized study showed that treatment with apolipoprotein A-I Milano (ApoA-I Milano) in a complex with phospholipids produced significant regression of the coronary atheroma burden in patients with acute coronary syndromes. 16039279 2005
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.060 Biomarker disease BEFREE APOA1 and APOB polymorphisms and apolipoprotein concentrations as biomarkers of risk in acute coronary syndrome: Relationship with lipid-lowering therapy effectiveness. 28992985 2018
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.060 AlteredExpression disease BEFREE Higher levels of apolipoprotein A-I early in life might reduce the risk of acute coronary syndromes. 8176109 1994
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury
0.300 Therapeutic disease CTD_human Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation. 20972769 2011
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.010 Biomarker disease BEFREE In this study, the RCT function of RBCs was assessed using cholesterol efflux capacity (CEC) assays, in which [3H]-labeled cholesterol-loaded human acute monocytic leukemia (THP-1) macrophages were incubated with RBCs as a cholesterol acceptor in the presence or absence of HDL or its main component protein apolipoprotein A-I (apoA-I). 31188743 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.060 Biomarker disease BEFREE CSL112 (Apolipoprotein A-I [Human]), an infusible, plasma-derived apolipoprotein A-I, is being developed to reduce cardiovascular events following acute myocardial infarction (AMI). 29582212 2018
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.060 Biomarker disease BEFREE CSL112 (apolipoprotein A-I [apoA-I; human]) is a novel formulation of apoA-I in development for reduction of early recurrent cardiovascular events after acute myocardial infarction. 29437574 2018
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.060 Biomarker disease BEFREE CSL112 (apolipoprotein A-I [human]) is a plasma-derived apolipoprotein A-I developed for early reduction of cardiovascular risk following an acute myocardial infarction (AMI). 30580130 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.060 Biomarker disease BEFREE CSL112 (Apolipoprotein A-I [human]) is an intravenous preparation of apolipoprotein A-I (apoA-I), formulated with phosphatidylcholine (PC) and stabilized with sucrose, in development to prevent early recurrent cardiovascular events following acute myocardial infarction (AMI). 30240132 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.060 Biomarker disease BEFREE PTX3, HbAlc and ApoA1/apoB have a certain clinical significance in assessing the severity of AMI combined with T2DM. 29731826 2018
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.060 Biomarker disease BEFREE ApoB and apoA1 were higher among patients in the upper versus lower tertiles of VA. During a median of 4.6 (3.6, 5.7) years of follow-up, 8.2% of patients experienced an AMI. 28774484 2017
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.010 GeneticVariation disease BEFREE The AUCs of APO A-I, HDL-C, the combination of APO A-I and BISAP, or the combination of APO A-I and MCTSI to predict persistent OF among Moderately severe acute pancreatitis (MSAP) and Severe acute pancreatitis (SAP) patients were 0.886, 0.811, 0.912, and 0.900 or among those with organ failure were 0.915, 0.859, 0.933, and 0.933, respectively. 29183667 2018
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.310 Biomarker group CTD_human Diverse proteomic alterations in gastric adenocarcinoma. 15378696 2004
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.310 AlteredExpression group LHGDN Expression of apolipoprotein A1 in colonic adenocarcinoma. 14666619 2003
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon
0.010 AlteredExpression disease BEFREE Expression of apolipoprotein A1 in colonic adenocarcinoma. 14666619 2003
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.300 Biomarker disease CTD_human Comparative proteome analysis of human adenocarcinoma. 19381893 2010
CUI: C0205641
Disease: Adenocarcinoma, Basal Cell
Adenocarcinoma, Basal Cell
0.300 Biomarker disease CTD_human Diverse proteomic alterations in gastric adenocarcinoma. 15378696 2004
CUI: C0205642
Disease: Adenocarcinoma, Oxyphilic
Adenocarcinoma, Oxyphilic
0.300 Biomarker disease CTD_human Diverse proteomic alterations in gastric adenocarcinoma. 15378696 2004