Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study suggested that T2DM, Lp(a), HDL-c, and ApoA1 were risk factors of CAD and that the IL-17A rs2275913 and IL-23R rs6682925 polymorphisms may contribute to susceptibility to CAD.
|
31074535 |
2019 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found that the levels of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), hypoxia-inducible factor 1 alpha-antisense RNA 2 (HIF1A-AS2) and apolipoprotein A-1 antisense RNA (APOA1-AS) were significantly increased in CAD patients (KCNQ1OT1 increased by 2.38-fold, P = 0.00042; HIF1A-AS2 increased by 2.00-fold, P = 0.0001; APOA1-AS increased by 4.52-fold, P = 0.000048).
|
30941792 |
2019 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Amyloid deposits of WT apolipoprotein A-I (apoA-I), the main protein component of high-density lipoprotein, accumulate in atherosclerotic plaques where they may contribute to coronary artery disease by increasing plaque burden and instability.
|
29853648 |
2018 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In fact, a significant increase of plasmatic triglycerides (TG) level, atherogenic lipid ratios (TC/HDL-C,TG/HDL-C, LDL-C/HDL-C); and ApoB/ApoA1 was observed in the CAD group comparatively to controls (p < 0.001).
|
28806974 |
2017 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A stronger association between APOA1-75G/A polymorphisms and CAD risk was present in the studies consistent with HWE.
|
28721149 |
2017 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer-Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study, and the Women's Health Study.
|
28775061 |
2017 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Anti-apoA-1 IgG are independent predictors of nonfatal incident CAD in the general population.
|
29074586 |
2017 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
ApoA1 showed negative association and Lp-PLA<sub>2</sub> concentration showed positive association with risk for CAD.
|
29302464 |
2017 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease.
|
27135400 |
2016 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The proinflammatory enzyme myeloperoxidase induces both oxidative modification and nitrosylation of specific residues on plasma and arterial apolipoprotein A-I to render HDL dysfunctional, which results in impaired ABCA1 macrophage transport, the activation of inflammatory pathways, and an increased risk of coronary artery disease.
|
26323267 |
2016 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men.
|
26535656 |
2015 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, because various genes, LDLR, CETP, APOA5, Apo E, Apo B, and Apo A-I, are associated with the precipitation of CAD associated with T2DM, a personalized diet-gene intervention therapy may be advocated to reduce the disease precipitation.
|
25470794 |
2015 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The individuals with the APOA1 -75 A allele were likely to have a lower risk of CAD as a result of its effect on higher serum concentrations of ApoA1 and HDL-C.
|
26173491 |
2015 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, HDL-C and apoA1 have been investigated as therapeutic targets for coronary heart disease.
|
24713591 |
2014 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, only mutation carriers with HDLc <5th percentile had elevated risk of CAD (odds ratio (OR)=2.26 for 34 ABCA1 mutation carriers vs. 149 total first-degree relative controls, p=0.05; OR=2.50 for 26 APOA1 mutation carriers, p=0.04; OR=3.44 for 38 LCAT mutation carriers, p=1.1∗10(-3)).
|
21875686 |
2012 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The goal is to identify Apo lipoprotein A1 (APOA1) gene polymorphisms and their association with CAD risk factors, metabolic syndrome and dysfunctional HDL (Dys-HDL).
|
22297598 |
2012 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In large meta-analyses, associations between FADS1-2-3 and carotid intima media thickness, AGPAT1 and type 2 diabetes, and APOA1 and coronary artery disease were observed.
|
22359512 |
2012 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although apolipoprotein A-I protein quantity in EAT was similar between CAD and non CAD patients, its released levels from this fat pad were lower in CAD.
|
22959663 |
2012 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The objective of the current study is to assess the prevalence of metabolic syndrome (MS), its association with high density Lipoprotein (HDL) function, Apo lipoprotein A-I (APOA1) gene polymorphisms, and sub-clinical CAD using common carotid intima-media thickness (CCA-IMT) as a surrogate marker.
|
21410987 |
2011 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein A-I (apoA-I) exerts many potentially anti-atherogenic properties and is therefore attractive for prevention and therapy of coronary heart disease.
|
21930241 |
2011 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
APOA1/C3/A4/A5 gene cluster is closely involved in lipid metabolism, and its polymorphisms have been associated with coronary heart disease and lipid plasma levels.
|
21712729 |
2011 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
His elder brother was also homozygous for apoA-I Tomioka with marked HDL cholesterol and apoA-I deficiency, but had no clinical evidence of coronary heart disease.
|
19473658 |
2009 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Association between lipoprotein(a) levels, apo(a) isoforms and family history of premature CAD in young Asian Indians.
|
18280807 |
2008 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Serum apolipoprotein E and apolipoprotein A1 levels were significantly lower in CAD patients than controls.
|
18398670 |
2008 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Serum apolipoprotein E and apolipoprotein A1 levels were significantly lower in CAD patients than controls.
|
18398670 |
2008 |