|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
These results demonstrate that 5-HT1A receptors are involved in the modulation of exploratory and fear-related behaviors and suggest that reductions in 5-HT1A receptor density due to genetic defects or environmental stressors might result in heightened anxiety.
|
9826725 |
1998 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
MGD |
These results demonstrate that 5-HT1A receptors are involved in the modulation of exploratory and fear-related behaviors and suggest that reductions in 5-HT1A receptor density due to genetic defects or environmental stressors might result in heightened anxiety.
|
9826725 |
1998 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
The serotonin system, and the serotonin(1A) (5-HT(1A)) receptor in particular, have been under intense investigation, mostly due to the fact that serotonergic drugs that directly or indirectly affect the 5-HT(1A) receptor, are effective therapeutic agents in treating patients with various neuropsychiatric disorders, including anxiety and depression.
|
11704418 |
2001 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
In contrast, the GABA(A)-BZ receptor system seems to function normally in the 5-HT(1A) R KO in the 129/Sv background suggesting that changes in the GABA(A)-BZ receptor system may not be a prerequisite for anxiety but rather could have a modifying effect on this phenotype.
|
11742137 |
2001 |
|
Anxiety Disorders
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Our findings indicate a role of allelic variation in 5-HT1A receptor expression in the development and modulation of anxiety- and depression-related personality traits.
|
14666415 |
2003 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
In this paper, studies focusing on anxiety using 5-HT1A receptor knockout (1AKO) and 5-HT1B receptor knockout (1BKO) mice are reviewed.
|
14501251 |
2003 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
While multiple lines of evidence implicate the 5-HT1A receptor in the pathophysiology of anxiety and depression as well as in the mechanism of action of anxiolytics/antidepressants, its relevance to the therapeutic effectiveness of these drugs has been a matter of considerable debate (for review see Griebel, 1995; Hensler, 2003; Hjorth et al., 2000; Lesch et al., 2003).
|
15683551 |
2004 |
|
Anxiety Disorders
|
0.300 |
GeneticVariation
|
group |
BEFREE |
A functional promoter polymorphism in the serotonin receptor 1A (5-HT1A) gene has been found to be associated with major depression as well as anxiety- and depression-related personality traits.
|
14984628 |
2004 |
|
Anxiety Disorders
|
0.300 |
AlteredExpression
|
group |
BEFREE |
As such, the level of expression of 5-HT1A receptors is implicated in the development of anxiety and depression phenotypes.
|
18639564 |
2008 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
In this study, we examined the serotonin 1A receptor gene, HTR1A, for its association with shared genetic risk across a range of anxiety and depression-related phenotypes.
|
18163385 |
2008 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
There is a growing amount of evidence showing the importance of 5-HT1A in different psychiatric disorders, from mood to anxiety disorders, moving through suicidal behaviour and psychotic disorders.
|
18047755 |
2008 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
Our findings further implicate relatively increased serotonin signaling, associated with a genetic variation that mediates increased 5-HT(1A) autoreceptors, in driving amygdala reactivity and trait anxiety.
|
19124686 |
2009 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
This overview of preclinical and clinical data provides strong evidence for the key role of the 5-HT1A receptor in the serotonergic dysregulation of anxiety disorders.
|
19423077 |
2009 |
|
Anxiety Disorders
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Altered expression of serotonin-1A (5-HT1A) receptors, both presynaptic in the raphe nuclei and post-synaptic in limbic and cortical target areas, has been implicated in mood disorders such as major depression and anxiety.
|
19423080 |
2009 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
MGD |
Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety.
|
20152131 |
2010 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
The 5-HT(1A) receptor is a metabotropic G protein-coupled receptor linked to the G(i/o) signaling pathway and has been specifically implicated in the pathogenesis of depression and anxiety.
|
20643652 |
2010 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
We investigated the possible association between depression and anxiety scores and SNPs within the HTR1A and HTR1B genes in a population sample (n=1387).
|
20638825 |
2011 |
|
Anxiety Disorders
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Targeted therapeutics to inhibit 5-HT(1A) autoreceptor expression and induce 5-HT(1A) heteroreceptor expression may ameliorate treatment of anxiety and major depression.
|
22826341 |
2012 |
|
Anxiety Disorders
|
0.300 |
GeneticVariation
|
group |
BEFREE |
C allele of 5-HT1A C-1019G polymorphism might be an independent risk factor for anxiety disorders in temporal lobe epilepsy.
|
22222329 |
2012 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
In this review, we examine the function of 5-HT(1A) receptor subpopulations and re-interpret our understanding of their role in mental illness in light of new data, separating both spatial (autoreceptor versus heteroreceptor) and the temporal (developmental versus adult) roles of the endogenous 5-HT(1A) receptors, emphasizing their distinct actions in mediating anxiety and depression-like behaviors.
|
24337875 |
2014 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
This work indicates that the effects of 5-HT1A autoreceptors on anxiety and social behaviors are developmentally mediated and suggests that natural variations in the expression of 5-HT1A may act during development to influence individual anxiety levels and contribute to susceptibility to anxiety disorders.
|
23907404 |
2014 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
Our results, therefore, translate evidence from animal studies to humans and suggest a central role for HTR1A in differentiating subgroups of patients with anxiety disorders.
|
25514753 |
2014 |
|
Anxiety Disorders
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Transcriptional dys-regulation in anxiety and major depression: 5-HT1A gene promoter architecture as a therapeutic opportunity.
|
24180393 |
2014 |
|
Anxiety Disorders
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The aim was to further characterize the impact of cue acquisition and trait anxiety, and of a single nucleotide polymorphism in the serotonin 1A receptor gene (5-HTR1A, rs6295), on cued fear and contextual anxiety before and after fear contingencies were explicitly introduced.
|
25448266 |
2015 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
Tandospirone, an azapirone derivative with strong and selective agonist effect on 5-HT1A receptor, has been used for the treatment of anxiety disorders especially generalized anxiety disorder for decades.
|
29254282 |
2017 |