HTR1A, 5-hydroxytryptamine receptor 1A, 3350

N. diseases: 229; N. variants: 9
Disease: Bipolar Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 GeneticVariation disease BEFREE Further studies should investigate the relationship between 5-HT1A polymorphisms and bipolar disorder in terms of mood episode and gender. 24460115 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease PSYGENET Further studies should investigate the relationship between 5-HT1A polymorphisms and bipolar disorder in terms of mood episode and gender. 24460115 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 GeneticVariation disease BEFREE Results from this expanded meta-analysis, which included our own new study, suggest that rs6295 (C-1019G) and rs878567 in HTR1A are related to the pathophysiology of MDs, with overlap between MDD and BP. 22752684 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease PSYGENET Results from this expanded meta-analysis, which included our own new study, suggest that rs6295 (C-1019G) and rs878567 in HTR1A are related to the pathophysiology of MDs, with overlap between MDD and BP. 22752684 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease BEFREE HTR1A may play an important role in the pathophysiology of BP, but not schizophrenia in the Japanese population. 20594600 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease PSYGENET HTR1A may play an important role in the pathophysiology of BP, but not schizophrenia in the Japanese population. 20594600 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease BEFREE Our study used in situ hybridization to quantify 5-HT(1A), 5-HT(1B), and 5-HT(2A) mRNA levels in the hippocampus (HC) and 5-HT(1A) and 5-HT(2A) mRNA levels in the dorsolateral prefrontal cortex (DLPFC) of subjects with a history of major depression disorder (MDD), bipolar disorder (BPD), schizophrenia, and a normal comparison group (15 subjects per group). 14744462 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease PSYGENET Our study used in situ hybridization to quantify 5-HT(1A), 5-HT(1B), and 5-HT(2A) mRNA levels in the hippocampus (HC) and 5-HT(1A) and 5-HT(2A) mRNA levels in the dorsolateral prefrontal cortex (DLPFC) of subjects with a history of major depression disorder (MDD), bipolar disorder (BPD), schizophrenia, and a normal comparison group (15 subjects per group). 14744462 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease PSYGENET In conclusion, our study does not provide evidence that the 5-HT1A gene plays either a major or a minor role in the genetic predisposition to schizophrenia, bipolar affective disorder, or Tourette's syndrome. 8546152 1995
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 GeneticVariation disease BEFREE Segregation and linkage analysis in five manic depression pedigrees excludes the 5HT1a receptor gene (HTR1A). 8333729 1993