HTR1A, 5-hydroxytryptamine receptor 1A, 3350

N. diseases: 229; N. variants: 9
Disease: Major depression, single episode ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024517
Disease: Major depression, single episode
Major depression, single episode 		0.350 Biomarker disease BEFREE We also found 14% higher 5-HT1A receptor binding (p = 0.045) and 21% lower SERT binding in BA 9 of individuals who had an MDE (p = 0.045). 31120232 2019
CUI: C0024517
Disease: Major depression, single episode
Major depression, single episode 		0.350 Biomarker disease PSYGENET Influence of the interaction between the serotonin 1A receptor C-1019G polymorphism and negative life stressors on the development of depression. 21577007 2011
CUI: C0024517
Disease: Major depression, single episode
Major depression, single episode 		0.350 Biomarker disease BEFREE Future studies should evaluate the role of genetic and environmental factors in producing elevated 5-HT(1A) BP(F) and MDD, and should examine whether 5-HT(1A) BP(F) is a vulnerability factor to MDEs that could have a role in screening high-risk populations for MDD. 19458612 2009
CUI: C0024517
Disease: Major depression, single episode
Major depression, single episode 		0.350 Biomarker disease PSYGENET Future studies should evaluate the role of genetic and environmental factors in producing elevated 5-HT(1A) BP(F) and MDD, and should examine whether 5-HT(1A) BP(F) is a vulnerability factor to MDEs that could have a role in screening high-risk populations for MDD. 19458612 2009
CUI: C0024517
Disease: Major depression, single episode
Major depression, single episode 		0.350 GeneticVariation disease BEFREE In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression). 18387740 2008
CUI: C0024517
Disease: Major depression, single episode
Major depression, single episode 		0.350 Biomarker disease PSYGENET Antidepressant treatment response across 5-HT1A-1019C/G genotype groups showed no differences in either Major Depressive Episode or major depression between genotype groups, whereas stratification for the melancholic subtype of depression revealed a significantly worse treatment response as conferred by the -1019CC genotype (p=0.02). 18387740 2008
CUI: C0024517
Disease: Major depression, single episode
Major depression, single episode 		0.350 Biomarker disease BEFREE Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study. 16395308 2006
CUI: C0024517
Disease: Major depression, single episode
Major depression, single episode 		0.350 Biomarker disease PSYGENET Genotyped and determined 5-HT(1A) binding potential (BP) by positron emission tomography (PET) using [carbonyl-C-11]-WAY-100635 in 28 medication-free MDD subjects during a current major depressive episode and 43 controls. 16154547 2006
CUI: C0024517
Disease: Major depression, single episode
Major depression, single episode 		0.350 Biomarker disease BEFREE Genotyped and determined 5-HT(1A) binding potential (BP) by positron emission tomography (PET) using [carbonyl-C-11]-WAY-100635 in 28 medication-free MDD subjects during a current major depressive episode and 43 controls. 16154547 2006
CUI: C0024517
Disease: Major depression, single episode
Major depression, single episode 		0.350 Biomarker disease PSYGENET Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study. 16395308 2006