HTR1A, 5-hydroxytryptamine receptor 1A, 3350

N. diseases: 229; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain
0.350 Biomarker phenotype BEFREE Electroacupuncture (EA) activates spinal 5-HT1A receptors to inhibit p-CaMKII to alleviate paclitaxel-induced pain. 29034548 2018
CUI: C0030193
Disease: Pain
Pain
0.350 Biomarker phenotype BEFREE Analgesic mouse models were established by intraperitoneal injection of emulsified sevoflurane, and the influence of p-MPPF (a specific antagonist of 5-HT1A Rs) intrathecal injection on the changes in tail-flick latency in tail-withdrawal test, pain threshold in hot-plate test (HPPT), and writhing times in acetic acid-induced writhing test were recorded. 28346918 2017
CUI: C0030193
Disease: Pain
Pain
0.350 Biomarker phenotype BEFREE These data highlight the role of 5-HT1A receptors in long-term effects of neonatal inflammatory pain and stress of short MI on adaptive behavior and possibility of correction of the pain and psychoemotional behavior that were altered by adverse pain/stress intervention using buspirone during critical adolescent period. 28184190 2017
CUI: C0030193
Disease: Pain
Pain
0.350 AlteredExpression phenotype BEFREE Thus, the new 5-HT1AR agonist identified in this work, 19, exhibits oral analgesic activity, and the results herein represent a step toward identifying new therapeutics for the control of pain. 24050112 2013
CUI: C0030193
Disease: Pain
Pain
0.350 Biomarker phenotype BEFREE Experiments in rodents suggest that 5-HT1A-agonism modulates pain in opposite directions at mild compared to high noxious intensities. 22952650 2012
CUI: C0030193
Disease: Pain
Pain
0.350 Therapeutic phenotype CTD_human These results help to establish large-magnitude 5-HT(1A) receptor activation as a new molecular mechanism of profound, central analgesia and suggest that F 13640 may be particularly effective against pain arising from severe tonic nociceptive stimulation. 12595749 2003