HTR1A, 5-hydroxytryptamine receptor 1A, 3350

N. diseases: 229; N. variants: 9
Disease: Panic Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 GeneticVariation disease BEFREE In this association study, the 1019C/G (rs6295) promoter polymorphism of the 5-HT1A receptor G/G genotype was associated with PD without AP in a Japanese population. 28096880 2017
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 Biomarker disease BEFREE The aim of this study was to investigate the involvement of 5-HT1A receptors on dorsal periaqueductal gray (dPAG) in the behavioral response related to panic disorder in type-1 DBT animals. 28799955 2017
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 GeneticVariation disease BEFREE Finally, monoaminergic 'risk' genes (SLC6A4, MAOA, HTR1A) were related to SAD, generalized anxiety disorder and women with panic disorder, anxiety traits and response to psychopharmacological and psychotherapeutic interventions. 26575296 2016
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 Biomarker disease BEFREE Serotonergic genes (5-HTT and HTR1A) and separation life events: gene-by-environment interaction for panic disorder. 23635830 2013
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 Biomarker disease RGD Serotonin-1A receptors in the dorsal periaqueductal gray matter mediate the panicolytic-like effect of pindolol and paroxetine combination in the elevated T-maze. 21421022 2011
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 GeneticVariation disease BEFREE The present study revealed that plasma concentration of PAX, 5-HTTLPR genotype, -1019C/G 5-HT(1A) genotype, PAS score at baseline, and adverse effects may influence the therapeutic response to PAX in patients with PD. 21688171 2011
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 Biomarker disease BEFREE We analyzed five genes, derived from pharmacological or translational mouse models, in a new case-control study of PD and SAD in European Americans: (1) the serotonin transporter (SLC6A4), (2) the serotonin receptor 1A, (3) catechol-O-methyltransferase, (4) a regulator of g-protein signaling and (5) the gastrin-releasing peptide receptor. 18663369 2010
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 Biomarker disease BEFREE This study reinforces the association between HTR1A and PD. 20817074 2010
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 GeneticVariation disease BEFREE Early response to selective serotonin reuptake inhibitors in panic disorder is associated with a functional 5-HT1A receptor gene polymorphism. 19800133 2010
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 Biomarker disease BEFREE Recent positron emission tomography (PET) studies have reported reduced 5-HT1A receptor binding in patients with panic disorder and social anxiety disorder, but not in posttraumatic stress disorder. 19423077 2009
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 GeneticVariation disease BEFREE Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T-C, CCKR1 246G-A, CCKR2 -215C-A, DRD1 -94G-A and COMT Val158Met, were selected for genotyping based on previous positive findings from genetic association studies in PD. 18832011 2008
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 GeneticVariation disease BEFREE Alterations in 5-HT1A receptor levels are implicated in mood disorders, and a functional C(-1019)G 5-HT1A promoter polymorphism has been associated with depression, suicide, and panic disorder. 16467535 2006
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 GeneticVariation disease BEFREE Association of the functional -1019C/G 5-HT1A polymorphism with prefrontal cortex and amygdala activation measured with 3 T fMRI in panic disorder. 16316476 2006
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 GeneticVariation disease LHGDN Regional brain activation on visual presentation of emotional facial stimuli was investigated in 20 patients with panic disorder by means of fMRI at 3 T. All patients were genotyped for the functional -1019C/G 5-HT1A and 5-HTTLPR polymorphisms. 16316476 2006
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 GeneticVariation disease BEFREE The association with major depression, suicide, and panic disorder of a new functional 5-HT1A polymorphism at C(-1019)G that selectively blocks repression of the 5-HT1A autoreceptor by NUDR further suggests a causative role for altered regulation of this receptor in predisposition to mental illness. 15534042 2004
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 GeneticVariation disease BEFREE Furthermore, the third study in this series by Huang and associates (2004) reveals an association of allelic variation of 5-HT1A receptor expression in a wide spectrum of psychopathology including schizophrenia, substance abuse, and panic disorder. 15683551 2004
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 Biomarker disease BEFREE Reduced 5-HT1A receptor binding has been reported in panic disorder. 15260943 2004
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 Biomarker disease LHGDN These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD. 14736842 2004
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 GeneticVariation disease BEFREE We investigated a possible association between this 5-HT1A gene promoter polymorphism and panic disorder by genotyping the 1019C>G single nucleotide polymorphism in 134 panic-disorder patients with and without agoraphobia and matched 134 controls. 14984628 2004
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.300 Biomarker disease BEFREE HTR1A and HTR2C showed no significant association with panic disorder. 12759158 2003