Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Epistatic Interaction Between 5-HT1A and Vascular Endothelial Growth Factor Gene Polymorphisms in the Northern Chinese Han Population With Major Depressive Disorder.
|
31057436 |
2019 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, the 5-HT1A receptor gene illustrates the convergence of genetic, epigenetic and posttranscriptional mechanisms in gene expression, neurodevelopment and neuroplasticity, and major depression.
|
30807072 |
2019 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
A Novel Alternative Splicing Mechanism That Enhances Human 5-HT1A Receptor RNA Stability Is Altered in Major Depression.
|
30093565 |
2018 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The 5-HT1A autoreceptor mediates feedback inhibition of serotonin (5-HT) neurons, and is implicated in major depression.
|
29636529 |
2018 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The 5-HT1A receptor in Major Depressive Disorder.
|
26851834 |
2016 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder.
|
26780922 |
2016 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association study of 5-HT1A, 5-HT2A polymorphisms with schizophrenia and major depressive disorder in the Han Chinese population.
|
27756686 |
2016 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Somatodendritic 5-hydroxytryptamine1A (5-HT1A) autoreceptor function in major depression as assessed using the shift in electroencephalographic frequency spectrum with buspirone.
|
23809646 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Interaction of 5-HTT and HTR1A gene polymorphisms in treatment responses to mirtazapine in patients with major depressive disorder.
|
24911443 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Genetic variation in brain-derived neurotrophic factor val66met allele is associated with altered serotonin-1A receptor binding in human brain.
|
24607934 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Transcriptional dys-regulation in anxiety and major depression: 5-HT1A gene promoter architecture as a therapeutic opportunity.
|
24180393 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Somatodendritic 5-hydroxytryptamine1A (5-HT1A) autoreceptor function in major depression as assessed using the shift in electroencephalographic frequency spectrum with buspirone.
|
23809646 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Transcriptional dys-regulation in anxiety and major depression: 5-HT1A gene promoter architecture as a therapeutic opportunity.
|
24180393 |
2014 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interaction of 5-HTT and HTR1A gene polymorphisms in treatment responses to mirtazapine in patients with major depressive disorder.
|
24911443 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Imaging the serotonin 1A receptor using [11C]WAY100635 in healthy controls and major depression.
|
23440462 |
2013 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Preclinical and imaging/post-mortem studies in humans provide strong support for the involvement of HTR1A and HTR2A genes in MD.
|
23547754 |
2013 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Twenty patients with DSM-IV PTSD (13 with comorbid major depressive disorder, [MDD]) and 49 healthy volunteers underwent PET imaging with 5-HT1A antagonist radioligand [C-11]WAY100635.
|
23408467 |
2013 |
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Targeted therapeutics to inhibit 5-HT(1A) autoreceptor expression and induce 5-HT(1A) heteroreceptor expression may ameliorate treatment of anxiety and major depression.
|
22826341 |
2012 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed.
|
22727709 |
2012 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In our study, the HTR1A C(-1019)G polymorphism was found to be associated to the frequent clinical presentation of comorbid MD and GAD, suggesting a common genetic background for mixed depression and anxiety states.
|
21512427 |
2011 |
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Over-expression of the 5-HT1A autoreceptor has been implicated in reducing serotonergic neurotransmission, and is associated with major depression and suicide.
|
21619616 |
2011 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The details of interaction between 5-HT(1a) receptors and Treg cells in major depression need further exploration.
|
19900711 |
2010 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Despite the fact that the contribution of the "genome" remains elusive when it comes to major depression, intriguing evidence has recently emerged pointing to sexually dimorphic influences of certain polymorphisms in genes related to the pathophysiology of major depression and antidepressant response, such as the serotonin transporter (5-HTT), serotonin 1A (5HT1A) receptor, monoamine oxidase A (MAO-A) and others.
|
20459391 |
2010 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder.
|
20453658 |
2010 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Decreased expression of Freud-1/CC2D1A, a transcriptional repressor of the 5-HT1A receptor, in the prefrontal cortex of subjects with major depression.
|
20392296 |
2010 |