HTR1A, 5-hydroxytryptamine receptor 1A, 3350

N. diseases: 229; N. variants: 9
Disease: Generalized seizures ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0234533
Disease: Generalized seizures
Generalized seizures 		0.310 AlteredExpression disease BEFREE Serotonin modulates epileptiform activity in either direction i.e administration of 5-HT agonists or reuptake inhibitors leads to the activation of 5-HT3 and 5-HT1A receptors tending to impede focal and generalized seizures, while depletion of brain 5-HT along with the destruction of serotonergic terminals leads to expanded neuronal excitability hence abatement of seizure threshold in experimental animal models. 29956631 2019
CUI: C0234533
Disease: Generalized seizures
Generalized seizures 		0.310 Therapeutic disease CTD_human Stimulation of 5-HT 1A receptors increases the seizure threshold for picrotoxin in mice. 16313900 2005
CUI: C0234533
Disease: Generalized seizures
Generalized seizures 		0.310 Biomarker disease CTD_human Stimulation of 5-HT 1A receptors increases the seizure threshold for picrotoxin in mice. 16313900 2005
CUI: C0234533
Disease: Generalized seizures
Generalized seizures 		0.310 Biomarker disease CTD_human Pilocarpine-induced status epilepticus increases cell proliferation in the dentate gyrus of adult rats via a 5-HT1A receptor-dependent mechanism. 12646302 2003
CUI: C0234533
Disease: Generalized seizures
Generalized seizures 		0.310 Therapeutic disease CTD_human Pilocarpine-induced status epilepticus increases cell proliferation in the dentate gyrus of adult rats via a 5-HT1A receptor-dependent mechanism. 12646302 2003
CUI: C0234533
Disease: Generalized seizures
Generalized seizures 		0.310 Therapeutic disease CTD_human The role of the central serotonergic system in pilocarpine-induced seizures: receptor mechanisms. 2533336 1989
CUI: C0234533
Disease: Generalized seizures
Generalized seizures 		0.310 Biomarker disease CTD_human The role of the central serotonergic system in pilocarpine-induced seizures: receptor mechanisms. 2533336 1989