HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.390 GeneticVariation disease BEFREE Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes. 19690620 2009
CUI: C0028754
Disease: Obesity
Obesity
0.390 Biomarker disease BEFREE The serotonin (5-HT) 5-HT2A receptor (5-HT2AR) and 5-HT2C receptor (5-HT2CR) in the central nervous system are implicated in a range of normal behaviors (e.g., appetite, sleep) and physiological functions (e.g., endocrine secretion) while dysfunctional 5-HT2AR and/or 5-HT2CR are implicated in neuropsychiatric disorders (e.g., addiction, obesity, schizophrenia). 30157263 2018
CUI: C0028754
Disease: Obesity
Obesity
0.390 GeneticVariation disease BEFREE Polymorphisms in the monoamine oxidase A (MAOA-LPR) and serotonin receptor 2A genes (rs6314) moderated the effect of food reinforcement on BMI, accounting for an additional 5-10% variance and revealed a potential role of the single nucleotide polymorphism, rs6314, in the serotonin 2A receptor as a differential susceptibility factor for obesity. 23544600 2013
CUI: C0028754
Disease: Obesity
Obesity
0.390 Biomarker disease BEFREE Novel pyrimidoazepine analogs as serotonin 5-HT(2A) and 5-HT(2C) receptor ligands for the treatment of obesity. 23537943 2013
CUI: C0028754
Disease: Obesity
Obesity
0.390 GeneticVariation disease BEFREE Increased abdominal obesity in subjects with a mutation in the 5-HT(2A) receptor gene promoter. 12079891 2002
CUI: C0028754
Disease: Obesity
Obesity
0.390 PosttranslationalModification disease BEFREE The aim of this study was to evaluate the association of HTR2A gene promoter methylation levels in white blood cells (WBC) with obesity traits and depressive symptoms in individuals with metabolic syndrome (MetS) enrolled in a behavioural weight loss programme. 24959950 2014
CUI: C0028754
Disease: Obesity
Obesity
0.390 GeneticVariation disease BEFREE Finally, we identified another two genetic variants, namely, rs17069005 in HTR2A gene and rs3776511 in SLC6A3A gene were associated with obesity at last follow-up. 27228958 2017
CUI: C0028754
Disease: Obesity
Obesity
0.390 GeneticVariation disease BEFREE Serotonin receptor 2A -1438G/A promoter polymorphism in relation to obesity and response to sibutramine. 21977970 2012
CUI: C0028754
Disease: Obesity
Obesity
0.390 GeneticVariation disease BEFREE However, the present study suggests the possibility that an abnormal production rate of the 5-HT(2A)R c.1438A>G gene product might lead to the development of abdominal obesity in men but not in women. 17922252 2009
CUI: C0028754
Disease: Obesity
Obesity
0.390 Biomarker disease CTD_human These results suggest that obesity increases hypothalamic 5-HT2A receptor gene expression, and pharmacologic inactivation of 5-HT2A receptors inhibits overfeeding and obesity in A(y) mice, but did not increase plasma adiponectin levels. 17097612 2006