Obesity
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Increased abdominal obesity in subjects with a mutation in the 5-HT(2A) receptor gene promoter.
|
12079891 |
2002 |
Obesity
|
0.390 |
Biomarker
|
disease |
CTD_human |
These results suggest that obesity increases hypothalamic 5-HT2A receptor gene expression, and pharmacologic inactivation of 5-HT2A receptors inhibits overfeeding and obesity in A(y) mice, but did not increase plasma adiponectin levels.
|
17097612 |
2006 |
Obesity
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes.
|
19690620 |
2009 |
Obesity
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
However, the present study suggests the possibility that an abnormal production rate of the 5-HT(2A)R c.1438A>G gene product might lead to the development of abdominal obesity in men but not in women.
|
17922252 |
2009 |
Obesity
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Serotonin receptor 2A -1438G/A promoter polymorphism in relation to obesity and response to sibutramine.
|
21977970 |
2012 |
Obesity
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the monoamine oxidase A (MAOA-LPR) and serotonin receptor 2A genes (rs6314) moderated the effect of food reinforcement on BMI, accounting for an additional 5-10% variance and revealed a potential role of the single nucleotide polymorphism, rs6314, in the serotonin 2A receptor as a differential susceptibility factor for obesity.
|
23544600 |
2013 |
Obesity
|
0.390 |
Biomarker
|
disease |
BEFREE |
Novel pyrimidoazepine analogs as serotonin 5-HT(2A) and 5-HT(2C) receptor ligands for the treatment of obesity.
|
23537943 |
2013 |
Obesity
|
0.390 |
PosttranslationalModification
|
disease |
BEFREE |
The aim of this study was to evaluate the association of HTR2A gene promoter methylation levels in white blood cells (WBC) with obesity traits and depressive symptoms in individuals with metabolic syndrome (MetS) enrolled in a behavioural weight loss programme.
|
24959950 |
2014 |
Obesity
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Finally, we identified another two genetic variants, namely, rs17069005 in HTR2A gene and rs3776511 in SLC6A3A gene were associated with obesity at last follow-up.
|
27228958 |
2017 |
Obesity
|
0.390 |
Biomarker
|
disease |
BEFREE |
The serotonin (5-HT) 5-HT2A receptor (5-HT2AR) and 5-HT2C receptor (5-HT2CR) in the central nervous system are implicated in a range of normal behaviors (e.g., appetite, sleep) and physiological functions (e.g., endocrine secretion) while dysfunctional 5-HT2AR and/or 5-HT2CR are implicated in neuropsychiatric disorders (e.g., addiction, obesity, schizophrenia).
|
30157263 |
2018 |