|
Abdominal Migraine
|
0.300 |
Biomarker
|
disease |
CTD_human |
2002 Wolff Award. 5 -HT2A receptor activation and nitric oxide synthesis: a possible mechanism determining migraine attacks.
|
12482207 |
2003 |
|
Abnormal behavior
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
The incidence of psychiatric disorders has been shown to have a strong genetic component, and we conducted this study to investigate whether the -1438A/G polymorphism of the HTR2A gene was associated with susceptibility to schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD).
|
23404241 |
2013 |
|
Abnormal behavior
|
0.090 |
PosttranslationalModification
|
phenotype |
BEFREE |
Further analysis is needed to identify intrinsic and extrinsic factors that modulate HTR2A methylation, and the mechanism by which this epigenetic variation influences fetal growth and leads to altered brain development, manifesting in psychiatric disorders.
|
25043477 |
2014 |
|
Abnormal behavior
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Fine mapping of the human 5-HTR2a gene to chromosome 13q14 and identification of two highly polymorphic linked markers suitable for association studies in psychiatric disorders.
|
10464662 |
1999 |
|
Abnormal behavior
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
We suggest a wider investigation of the HTR2A gene to better understand its role in psychiatric disorders, preferably complemented with the use of proteomic or metabolomic approaches.
|
17691947 |
2007 |
|
Abnormal behavior
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The present findings highlight the role of the 5-HT2A receptor system in executive functions and working memory and suggest that specific 5-HT2A antagonists may be relevant for improving cognitive dysfunctions in psychiatric disorders.
|
31500679 |
2019 |
|
Abnormal behavior
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
Differential DNA methylation has been suggested to contribute to differential activity of alleles C and T and thereby to genetic associations between the C/T(102) polymorphism in the 5-HT2A receptor gene (5HT2AR) and psychiatric disorders.
|
16358338 |
2006 |
|
Abnormal behavior
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
However, although polymorphisms of the HTR2A gene have been associated with both obesity and psychiatric disorders, the role of HTR2A gene methylation in these illnesses remains uncertain.
|
24959950 |
2014 |
|
Abnormal behavior
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Behavioral observations indicated that unlike the 5-HT(2A) agonist (+/-)-1-(2,5-dimethoxy-4-phenyl)-2-aminopropane, lorcaserin did not induce behavioral changes indicative of functional 5-HT(2A) agonist activity.
|
18252809 |
2008 |
|
Abnormal behavior
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Alterations in 5-HT(1A,) 5-HT(1B), and 5-HT(2A) mRNA levels in the brains of subjects with both mood disorders and schizophrenia add further support for hypothesis of dysregulation of the serotonergic system in these psychiatric disorders.
|
14744462 |
2004 |
|
Abnormality of the cranial nerves
|
0.010 |
Biomarker
|
disease |
BEFREE |
The antagonist activities of lurasidone on serotonin 5‑HT7, serotonin 5‑HT2A, serotonin 5‑HT1A and serotonin 5‑HT6 were analyzed, and the preclinical therapeutic effects of lurasidone were examined in a rat model of cranial nerve involvement.
|
29436643 |
2018 |
|
Absence Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present results suggest that the serotonergic system negatively regulates the incidence of absence seizures by stimulation of 5-HT(1A) and 5-HT(2) receptors.
|
20736508 |
2010 |
|
Absence Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The present results suggest that the serotonergic system negatively regulates the incidence of absence seizures by stimulation of 5-HT(1A) and 5-HT(2) receptors.
|
20736508 |
2010 |
|
Acute Chest Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate whether polymorphisms of serotonin transporter (5-HTT) and serotonin 2a receptor (5-HTR2a) genes are associated with occurrence of depressive disorder in ACS.
|
25772786 |
2015 |
|
Acute Confusional Migraine
|
0.300 |
Biomarker
|
disease |
CTD_human |
2002 Wolff Award. 5 -HT2A receptor activation and nitric oxide synthesis: a possible mechanism determining migraine attacks.
|
12482207 |
2003 |
|
Acute myocardial infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The TT genotype of the 5-HT2A receptor gene may enhance susceptibility to AMI.
|
10781645 |
2000 |
|
Acute myocardial infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
5-Hydroxytryptamine 5-HT2A receptor and 5-hydroxytryptamine transporter polymorphisms in acute myocardial infarction.
|
12605580 |
2003 |
|
Acute myocardial infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
T102C polymorphism of the serotonin receptor 2A gene (5-HT2A) has been shown to be associated with certain diseases such as non-fatal acute myocardial infarction, essential hypertension, and alcoholism.
|
17713649 |
2007 |
|
Addictive Behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The serotonin (5-HT) 5-HT2A receptor (5-HT2AR) and 5-HT2C receptor (5-HT2CR) in the central nervous system are implicated in a range of normal behaviors (e.g., appetite, sleep) and physiological functions (e.g., endocrine secretion) while dysfunctional 5-HT2AR and/or 5-HT2CR are implicated in neuropsychiatric disorders (e.g., addiction, obesity, schizophrenia).
|
30157263 |
2018 |
|
Alcohol abuse
|
0.510 |
Biomarker
|
disease |
PSYGENET |
Alcohol abuse by itself did not have a significant effect on PFC 5-HT(2A) binding and as 5-HT(2A) binding in alcoholics is not different from controls and antagonists may be therapeutic, fewer receptors may result in downstream developmental effects on the brain resulting in a predisposition to alcoholism.
|
18241316 |
2008 |
|
Alcohol abuse
|
0.510 |
Biomarker
|
disease |
BEFREE |
Alcohol abuse by itself did not have a significant effect on PFC 5-HT(2A) binding and as 5-HT(2A) binding in alcoholics is not different from controls and antagonists may be therapeutic, fewer receptors may result in downstream developmental effects on the brain resulting in a predisposition to alcoholism.
|
18241316 |
2008 |
|
Alcohol abuse
|
0.510 |
Biomarker
|
disease |
PSYGENET |
Finally, because both the opiate and 5-HT2A antagonists reduce the ingestion of saccharin and chocolate solutions differentially, it is apparent that preferences for alternative palatable fluids should be examined when candidate drugs are screened for suppressing alcohol drinking and ultimately the treatment of alcohol abuse.
|
9632223 |
1998 |
|
Alcohol abuse
|
0.510 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Alcohol Use Disorder
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis supports a contribution of the HTR2A gene to the susceptibility to substance use disorders, particularly alcohol dependence.
|
24178752 |
2014 |