HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 Biomarker disease BEFREE The ability of atypical antipsychotics to block both 5-HT(2) and D(2) receptors and downregulate 5-HT(2) receptors may explain how these drugs treat both the depressive and manic symptoms of bipolar disorder. 15948763 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 AlteredExpression disease BEFREE Our study used in situ hybridization to quantify 5-HT(1A), 5-HT(1B), and 5-HT(2A) mRNA levels in the hippocampus (HC) and 5-HT(1A) and 5-HT(2A) mRNA levels in the dorsolateral prefrontal cortex (DLPFC) of subjects with a history of major depression disorder (MDD), bipolar disorder (BPD), schizophrenia, and a normal comparison group (15 subjects per group). 14744462 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 Biomarker disease BEFREE We did not detect significant an association of HTR2A with MDD and BP in allele/genotype-wise or haplotype-wise analysis. 19428704 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE Many studies investigated the association between MDD and BD with the 5-HT2A 102 T/C, the 5-HTT promoter 44 bp insertion/deletion and the intron 2 VNTR polymorphisms, and thus, these could be pooled using meta-analytic techniques. 12851635 2003
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 Biomarker disease BEFREE The lack of association suggests that HTR2A is not a major risk factor for bipolar affective disorder. 9341875 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE Despite the limited sample size, these results exclude a major effect of the 5-HTR2a polymorphism on bipolar disorder and HA personality trait but not a minor effect. 10898915 2000
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE Ongoing research has identified a region of the HTR2A promoter that has been associated with a number of medical outcomes in adults and infants, including bipolar disorder, schizophrenia, chronic fatigue syndrome, borderline personality disorder, suicidality, and neurobehavioral outcomes. 25043477 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE These results indicate that, in our sample, the 5-HT2A receptor polymorphism studied is unlikely to play a major role in the genetic susceptibility to BPAD.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:136-140, 2000. 10893484 2000
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 Biomarker disease BEFREE Polymorphisms within the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes are being studied for association with lithium prophylaxis in a sample of 155 Sardinian unrelated probands affected by bipolar disorder (BP). 19647327 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE We previously reported linkage evidence for a bipolar affective disorder susceptibility locus on chromosome 13q, which harbours HTR2A, thus making the gene both a positional and functional candidate. 19584773 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder. 17221840 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE Although further studies are necessary, these results in a Korean population suggest that -1438A/G polymorphism of 5-HT2A receptor gene promoter may be causally related to the development of bipolar disorder. 11702051 2001
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE The association detected in this study suggests that the 5-HT(2A) receptor gene may play a role in the genetic susceptibility to bipolar disorder, through a specific subgroup of bipolar type I patients with lower risk of suicidal behavior. 11983190 2002
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE These preliminary results may indicate that in our sample the 5-HT2 receptor polymorphism studied is unlikely to play a role in the genetic susceptibility to BPAD. 9194200 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE Cytosine methylation of HTR2A at T102C polymorphic site in DNA derived from the saliva can potentially be used as a diagnostic, prognostic, and/or therapeutic biomarker in SCZ and BD. 21598376 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE In secondary analyses, HTR2A (rs643627, p = 0.002) and CHL1 (rs4003413, p = 0.002) were found associated with risk for BD, HOMER1 (rs6872497, p = 0.002) with lifetime history of suicide attempt in patients, and RORA with early onset and presence of psychotic features in BD. 30178121 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE We found that the association of the HTR2A -1438A/G polymorphism with SZ depends on the ethnic origin of the study population, and this genetic variant does not modify the susceptibility to BD or MDD. 23404241 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE The 5-HT2A receptor gene was systematically screened for genetic variants by single strand conformation polymorphism (SSCP) methods in subjects with bipolar affective disorder. 9086465 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 GeneticVariation disease BEFREE No significant transmission disequilibrium between the alleles of 5-HT2A and BP was found. 12622403 2002
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.800 AlteredExpression disease BEFREE Furthermore, epigenetic down-regulation of HTR2A was associated with early age of disease onset in SCZ and BD. 21550210 2011
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 GeneticVariation disease BEFREE The meta-analysis supports a contribution of the HTR2A gene to the susceptibility to substance use disorders, particularly alcohol dependence. 24178752 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 GeneticVariation disease BEFREE The results suggest that the human HTR2 MspI polymorphism might not be associated with a risk factor for developing alcohol dependence or susceptibility to schizophrenia. 10754425 2000
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 GeneticVariation disease BEFREE There was no association between the 5-HT2A receptor polymorphism (T102C), the intron 7 TPH (A218C) polymorphisms and alcohol dependence, panic disorder, generalized anxiety disorder and narcolepsy in our subsets of German patients. 11444684 2001
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 Biomarker disease BEFREE 5-HT(2A) receptor binding in alcoholics without a family history of alcoholism (n = 7) did not differ from controls without a family history of alcoholism (n = 14). 18241316 2008
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 GeneticVariation disease BEFREE The aim of the present study was to test for possible associations between the A-1438G polymorphism in the serotonin receptor gene (HTR2A) with tobacco smoking combined or not with alcohol dependence. 19111403 2009