HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 GeneticVariation disease BEFREE Our data show a significant association between polymorphisms with the gene encoding HTR2A with both AN subtypes, an association between polymorphisms within the genes encoding HTR1D and HTR1B with RAN, and an association between polymorphisms within the gene encoding HTR2C with BPAN. 20545463 2010
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 GeneticVariation disease BEFREE Results of this study support previous reports of a significant role of the A allele (-1438A/G, 5-HT2A receptor) as a risk factor in anorexia nervosa. 19863848 2009
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 GeneticVariation disease BEFREE We hypothesized that the 5-HT2A promoter polymorphism, -1438G>A, previously associated with anorexia nervosa, would be more abundant in women with obsessive-compulsive disorder. 11239910 2001
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 GeneticVariation disease BEFREE We genotyped the -1438 A/G polymorphism in the 5-HT2A receptor gene and serotonin transporter linked-polymorphic region (5-HTTLPR) in 132 adolescent subjects with AN and in 93 healthy controls. 16397402 2006
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 GeneticVariation disease BEFREE A 5-HT2A receptor promoter polymorphism, -1438G/A, was reported to be significantly increased in patients with anorexia nervosa when compared with controls. 9601682 1998
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 GeneticVariation disease BEFREE 5-HT(2A) gene promoter polymorphism as a modifying rather than a vulnerability factor in anorexia nervosa. 12231269 2002
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 GeneticVariation disease BEFREE Analysis of the -1438 G/A polymorphism of the 5-HT2A serotonin receptor gene in bulimia nervosa patients with or without a history of anorexia nervosa. 15167698 2004
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 GeneticVariation disease BEFREE To examine the distribution of different polymorphisms in genes of the 5-HT system in patients with anorexia nervosa (AN) and bulimia nervosa (BN), we analyzed the distribution of a polymorphism (-1438G/A) and the presence of known mutations in 5-HT2A and 5-HT2C receptor genes in 168 Italian female patients affected by AN and BN. 10624828 1999
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 GeneticVariation disease BEFREE Four studies of a polymorphism (-1438 G/A) within the promoter of the 5-HT(2A) gene (5-HT(2A)) revealed an association of the A-allele to anorexia nervosa. 11134666 2000
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 GeneticVariation disease LHGDN 5-HT(2A) gene promoter polymorphism as a modifying rather than a vulnerability factor in anorexia nervosa. 12231269 2002
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 GeneticVariation disease BEFREE Thus, at least for Japanese subjects, the A-allele of the -1438G/A polymorphism in the promoter region of the 5-HT2A receptor gene does not contribute to a predisposition to AN. 11702058 2001
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 GeneticVariation disease BEFREE We thus found no evidence for a significant role of the 5-HT(2A) gene in anorexia nervosa. 11803452 2002
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 Biomarker disease CTD_human
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 Biomarker disease BEFREE Although, at present, no convincing evidence for associations of candidate genes with EDs has been provided, the 5-HT(2A) receptor gene and the BDNF gene seem to be promising candidates for genetic influences on AN, since polymorphic variants of these genes have been found quite consistently, although not specifically, linked to AN restricting subtype in large sample studies. 18855537 2008
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa
0.400 Biomarker disease LHGDN The 5-HT(2A) -1438G/A polymorphism in anorexia nervosa: a combined analysis of 316 trios from six European centres. 11803452 2002