Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CCONSLUSIONS: We have found that a 5-HT2A promoter polymorphism is associated with obsessive-compulsive disorder in women but not in men, strengthening the argument that there may be fundamental gender differences in the genetic susceptibility to obsessive-compulsive disorder.
|
11239910 |
2001 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this, to our knowledge, first association study based on children and adolescents with OCD, we confirm an association of the A-allele of the 5-HT2A receptor gene with OCD.
|
12476319 |
2002 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
In this, to our knowledge, first association study based on children and adolescents with OCD, we confirm an association of the A-allele of the 5-HT2A receptor gene with OCD.
|
12476319 |
2002 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The distribution of selected polymorphic variants in the serotonin receptor type 2A and 1Dbeta (5-HT(2A), 5-HT(1Dbeta)), dopamine transporter (DAT), dopamine receptor type 4 (DRD4) and monoamine-oxidase A (MAO-A) genes were analysed in 71 OCD cases and 129 control individuals in the genetically homogeneous Afrikaner population, by means of case-control association studies.
|
12650952 |
2003 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The -1438 G/A and T102C polymorphisms of the 5-HT2A receptor gene are not associated with an increased risk of OCD.
|
12927326 |
2003 |
Obsessive-Compulsive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The only parameter that appeared to discriminate affected and unaffected subjects was 5-HT2A receptor-binding characteristics, with increased receptor number and affinity in parents and no change in OCD probands.
|
15886722 |
2005 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, taking in account OCD phenotypes, we found indication towards an association of the 5-HTTLPR S-allele with female OCD patients, and the 5-HT2A G-allele and GG genotype with patients with a positive family history of OCD and an early onset of disease.
|
16443280 |
2006 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Nominally significant association was found at the HTR2A rs6311 polymorphism in subjects with tic disorder and OCD (p = .05), replicating a previous finding in Tourette syndrome and OCD.
|
17241828 |
2007 |
Obsessive-Compulsive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The purpose of the present study was to determine whether polymorphisms of the serotonin transporter (5-HTT), 5-HT1B, and 5-HT2A receptor genes affect the efficacy of SRI treatment in OCD.
|
17503984 |
2007 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study is to investigate the association between four serotonergic polymorphisms (STin2 VNTR and 5-HTTLPR of the SLC6A4 gene, and A-1438G (rs6311) and rs6313" genes_norm="3356">T102C (rs6313) of the HTR2A gene) and OCD.
|
18191318 |
2008 |
Obsessive-Compulsive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
As several other uncommon, less well quantitated genetic variations occur with an OCD phenotype, including chromosomal anomalies and some other rare gene variants (SGCE, GCH1 and SLITRK1), a tentative conclusion is that OCD resembles other complex disorders in being etiologically heterogeneous and in having both highly penetrant familial subtypes associated with rare alleles or chromosomal anomalies, as well as having a more common, polygenetic form that may involve polymorphisms in such genes as BDNF, COMT, GRIN2beta, TPH2, HTR2A and SLC1A1.
|
18197083 |
2008 |
Obsessive-Compulsive Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
The 5-HT2 receptor profiles of antipsychotics in the pathogenesis of obsessive-compulsive symptoms in schizophrenia.
|
19644229 |
2009 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Serotonin and catecholamine system studies provide increasing evidence for the importance of genetic factors in obsessive-compulsive disorder (OCD); we found that genetic linkage disequilibrium with OCD existed in the 5-HT2A-receptor promoter polymorphism -1438G/A.
|
20937529 |
2011 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results pointed to the functional importance of this promoter region of HTR2A; it influenced the occurrence, the onset, and the severity of OCD.
|
21874579 |
2012 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the main meta-analysis, OCD was associated with serotonin-related polymorphisms (5-HTTLPR and HTR2A) and, in males only, with polymorphisms involved in catecholamine modulation (COMT and MAOA).
|
22665263 |
2013 |
Obsessive-Compulsive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
While the hypo-activity of serotonin signaling is involved in the pathogenesis of depression, anxiety and obsessive compulsive disorder; LSD, an agonist of serotonin type 2 receptor (5-HTR2A) induces psychosis.
|
24411530 |
2014 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results confirmed that OCD is associated with polymorphisms of 5-HTTLPR, HTR2A, and, in males only, COMT.
|
26616111 |
2016 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although findings to date are mixed, serotonin transporter polymorphism 5-HTTLPR and HTR2A polymorphism rs6311 (or rs6313) are most consistently associated with OCD.
|
28576508 |
2017 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although we did not observe any statistically significant association between the HTR2A gene polymorphisms and OCD or its clinical features, SLC6A4 STin2 polymorphism was significantly more common among OCD patients as compared to health controls.
|
29331882 |
2018 |
Obsessive-Compulsive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, the associations of serotonin receptor 2a polymorphisms rs6311 and rs6313 with OCD, its familial form and fluvoxamine treatment response in Iranian population were investigated.
|
29785111 |
2018 |