Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Negative association between T102C polymorphism at the 5-HT2A receptor gene and bipolar affective disorders in Singaporean Chinese.
|
10802129 |
2000 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Some evidence implicates methylation of the promoter regions of the DRD2 and HTR2A genes in schizophrenia and mood disorders as well.
|
15108180 |
2004 |
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The serotonin 2A (5-HT2A) receptor gene has been implicated in the pathogenesis of suicidal behaviour by a genetic association between the 5-HT2A T102C silent polymorphism and suicidality in patients with mood disorders and schizophrenia.
|
18783799 |
2009 |
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
5-HT2A gene variants influence specific and different aspects of antidepressant response in Japanese and Italian mood disorder patients.
|
19361869 |
2009 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
In particular, the implication of central postsynaptic 5-HT2A receptor in affective disorders has been supported by findings consistent with the hypothesis of 5-HT2A receptor up-regulation in depression.
|
10893484 |
2000 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The aim of our study was to investigate a possible influence of monoamine oxydase A (MAO-A), catechol-O-methyltransferase (COMT), serotonin receptor 2A (5-HT2A), dopamine receptor D2 (DRD2), and dopamine receptor D4 (DRD4) gene variants on timing of recurrence in mood disorders.
|
11992560 |
2002 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
We studied 5-HT2A receptor exons and the adjacent intron regions in 102 patients with mood disorders (71 depressive disorders and 31 bipolar disorders).
|
9084895 |
1997 |
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Association of 5-HT(2A) receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk.
|
11983190 |
2002 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, 5-HT2A receptors are thought to play a role in the etiologies of mood disorders.
|
9601682 |
1998 |
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Personality traits detected by TCI may not be directly related to the 5-HT(2A) receptor function or 5-HT(2A) receptor gene polymorphism which may be involved in the vulnerability of affective disorders.
|
12063151 |
2002 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The TT genotype appears associated with higher platelet 5-HT2A Bmax in the healthy population, but this genotypic effect appears absent in mood disorders and unrelated to psychopathology.
|
15483560 |
2005 |
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
5-HT2A and 2C variants are not, therefore, associated with lithium prophylactic efficacy in mood disorders.
|
10758249 |
2000 |
Mood Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Alterations in 5-HT(1A,) 5-HT(1B), and 5-HT(2A) mRNA levels in the brains of subjects with both mood disorders and schizophrenia add further support for hypothesis of dysregulation of the serotonergic system in these psychiatric disorders.
|
14744462 |
2004 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Depression may be associated with altered serotonergic function in the auditory cortex involving the 5-HT2A receptor and is part of a wider view of the pathophysiology of mood disorders extending beyond psychopathology.
|
31120232 |
2019 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The serotonin 2A receptor gene (HTR2A) is involved in serotonergic neurotransmission, and has been targeted as a functional candidate for mood disorders because of the extensive support for the involvement of serotonin in mood regulation.
|
19584773 |
2009 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we could detect no evidence of genetic association between 4 markers near HTR2A and mood disorders in the Japanese population, but sample sizes, especially BP, were probably too small to allow a meaningful test.
|
19428704 |
2009 |
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetic variation at the 5-HT2A receptor gene does not, therefore, appear to play a major role in the pathogenesis of major mood disorders.
|
10482339 |
1999 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Childhood anxiousness did not mediate the effects of HTR2A and HTR5A on mood disorders, nor did childhood disruptiveness mediate the effects of TPH1 on suicide attempts.
|
19381154 |
2010 |
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The gene with the lowest p-value in the DLPFC was the 5-HT2A gene, previously associated both with suicide and mood disorders.
|
22558144 |
2012 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (ADHD), affective disorders, eating disorders, anxiety disorders, obsessive-compulsive disorder, suicide and Alzheimer's disease (AD).
|
16026119 |
2005 |
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Alterations in 5-HT(1A,) 5-HT(1B), and 5-HT(2A) mRNA levels in the brains of subjects with both mood disorders and schizophrenia add further support for hypothesis of dysregulation of the serotonergic system in these psychiatric disorders.
|
14744462 |
2004 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
The gene with the lowest p-value in the DLPFC was the 5-HT2A gene, previously associated both with suicide and mood disorders.
|
22558144 |
2012 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Childhood anxiousness did not mediate the effects of HTR2A and HTR5A on mood disorders, nor did childhood disruptiveness mediate the effects of TPH1 on suicide attempts.
|
19381154 |
2010 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
5-HT2A gene variants influence specific and different aspects of antidepressant response in Japanese and Italian mood disorder patients.
|
19361869 |
2009 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
The serotonin 2A receptor gene (HTR2A) is involved in serotonergic neurotransmission, and has been targeted as a functional candidate for mood disorders because of the extensive support for the involvement of serotonin in mood regulation.
|
19584773 |
2009 |