HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 Biomarker disease HPO
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 Biomarker disease BEFREE We studied 5-HT2A receptor exons and the adjacent intron regions in 102 patients with mood disorders (71 depressive disorders and 31 bipolar disorders). 9084895 1997
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 Biomarker disease BEFREE The interaction of many neuroleptics and antidepressants with 5-HT2A receptors points up the potential importance of this receptor for understanding and treating neuropsychiatric disorders such as schizophrenia and depression. 9928234 1998
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 AlteredExpression disease BEFREE In particular, the implication of central postsynaptic 5-HT2A receptor in affective disorders has been supported by findings consistent with the hypothesis of 5-HT2A receptor up-regulation in depression. 10893484 2000
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 Biomarker disease BEFREE The serotonin 2A receptor gene (5-HT2A) is of great interest for research in neuropsychiatric disorders based on the observation that various neuroleptic agents and antidepressants bind with relatively high affinity at 5-HT2A receptors, and the fact that the receptor density in platelets tends to increase in depression. 12622403 2002
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 Biomarker disease BEFREE Upregulation and/or increased sensitivity of 5-HT2A/1B receptors and downregulated 5-HT transporter receptors in the periphery may contribute to increased risk of thromboembolic events in patients with depression and cardiovascular disease. 14508013 2004
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 Biomarker disease BEFREE HTR2A and TPH significantly predicted the depression group, independent of the effects of sex, environmental risk group and their interaction. 15241435 2004
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 Biomarker disease BEFREE A suggestive association of sequence variations in genes responsible for the synthesis (TPH), recognition (5-HTR2A), and degradation (MAOA) of serotonin with depression symptomatology was found, although the effect was generally restricted to men. 16806099 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 AlteredExpression disease BEFREE Altered HTR2A expression has been found in relation to several neuropsychiatric conditions, including depression and schizophrenia. 17069769 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 GeneticVariation disease BEFREE The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5-HT2A and serotonin transporter linked polymorphic region -5-HTTLPR- of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy. 17183148 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 Biomarker disease BEFREE The HTR2A gene may be involved in the development of depression by influencing the ability of individuals to use environmental support. 17339524 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 Biomarker disease BEFREE The HTR2A gene may be involved in the development of depression by influencing how individuals respond to environmental conditions. 17510953 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 GeneticVariation disease BEFREE Reports have shown an association of a serotonin-2A receptor (HTR2A) gene T102C polymorphism with AD + P and with depression during AD. 17525976 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 AlteredExpression disease BEFREE Alterations in the constitutive activity of 5-HT(2A) and 5-HT(2C) receptor systems could be involved in the mechanisms underlying anxiety and depression or exploited for therapeutic benefit. 18772038 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 GeneticVariation disease BEFREE 5-HT2A receptor gene polymorphism rs6313 was associated with 5-HT2A receptor binding potential, with the ability of individuals to use environmental support in order to prevent depression, and with sleep improvement after antidepressant treatment with mirtazapine. 18801406 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 Biomarker disease BEFREE Stress and anxiety disorders are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (CRFR1) and serotonin receptor (5-HT(2)R). 20383137 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 GeneticVariation disease BEFREE SNPs in HTR2A were associated with both pain phenotypes in the discovery cohort, and a number of these SNP associations were replicated in the validation cohort, some of which were attenuated after adjustment for depression. 21305503 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 GeneticVariation disease BEFREE This study aimed to investigate whether polymorphisms of interest in 5-HTT, 5-HTR2a, and BDNF genes are associated with depression after mastectomy for breast cancer. 22210241 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 GeneticVariation disease BEFREE To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. 23157339 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 Biomarker disease PSYGENET Targeted analysis of HTR2A in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study reveals associations between functional variants and depression severity or citalopram response. 23158458 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 GeneticVariation disease BEFREE Targeted analysis of HTR2A in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study reveals associations between functional variants and depression severity or citalopram response. 23158458 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 GeneticVariation disease BEFREE The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome. 23537781 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 GeneticVariation disease BEFREE Associations between suicidal ideation and 5-HTTLPR, STin2 VNTR, 5-HTR2a 1438A/G, and 5-HTR2a 102T/C genotypes were estimated using logistic regression models, and gene-gene interactions were investigated using the generalized multifactor dimensionality reduction method after adjustment for potential covariates, including depression. 23973249 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 Biomarker disease PSYGENET Associations between suicidal ideation and 5-HTTLPR, STin2 VNTR, 5-HTR2a 1438A/G, and 5-HTR2a 102T/C genotypes were estimated using logistic regression models, and gene-gene interactions were investigated using the generalized multifactor dimensionality reduction method after adjustment for potential covariates, including depression. 23973249 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.500 Biomarker disease PSYGENET The frontal abnormality of patients with depression had certain 5-HT genetic basis, and 5-HT2A receptor CC allele and MAOA-H genotype had synergistic effect on the activity abnormality when recognizing negative emotion in right frontal middle gyrus of patients with depression. 24314147 2014