HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease HPO
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease BEFREE Depression may be associated with altered serotonergic function in the auditory cortex involving the 5-HT2A receptor and is part of a wider view of the pathophysiology of mood disorders extending beyond psychopathology. 31120232 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease BEFREE HTR2A and TPH significantly predicted the depression group, independent of the effects of sex, environmental risk group and their interaction. 15241435 2004
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 GeneticVariation disease BEFREE 5-HT2A receptor gene polymorphism rs6313 was associated with 5-HT2A receptor binding potential, with the ability of individuals to use environmental support in order to prevent depression, and with sleep improvement after antidepressant treatment with mirtazapine. 18801406 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease BEFREE A suggestive association of sequence variations in genes responsible for the synthesis (TPH), recognition (5-HTR2A), and degradation (MAOA) of serotonin with depression symptomatology was found, although the effect was generally restricted to men. 16806099 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 AlteredExpression disease BEFREE Alterations in the constitutive activity of 5-HT(2A) and 5-HT(2C) receptor systems could be involved in the mechanisms underlying anxiety and depression or exploited for therapeutic benefit. 18772038 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 AlteredExpression disease BEFREE Altered HTR2A expression has been found in relation to several neuropsychiatric conditions, including depression and schizophrenia. 17069769 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease PSYGENET Associations between suicidal ideation and 5-HTTLPR, STin2 VNTR, 5-HTR2a 1438A/G, and 5-HTR2a 102T/C genotypes were estimated using logistic regression models, and gene-gene interactions were investigated using the generalized multifactor dimensionality reduction method after adjustment for potential covariates, including depression. 23973249 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 GeneticVariation disease BEFREE Associations between suicidal ideation and 5-HTTLPR, STin2 VNTR, 5-HTR2a 1438A/G, and 5-HTR2a 102T/C genotypes were estimated using logistic regression models, and gene-gene interactions were investigated using the generalized multifactor dimensionality reduction method after adjustment for potential covariates, including depression. 23973249 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease PSYGENET DNA hypermethylation of serotonin transporter gene promoter in drug naïve patients with schizophrenia. 24411530 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease PSYGENET FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like. 25106036 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease BEFREE FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like. 25106036 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 AlteredExpression disease BEFREE In particular, the implication of central postsynaptic 5-HT2A receptor in affective disorders has been supported by findings consistent with the hypothesis of 5-HT2A receptor up-regulation in depression. 10893484 2000
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 GeneticVariation disease BEFREE Increasing number of pregnant women at risk of depression are being treated with selective serotonin reuptake inhibitors (SSRI) that bind to serotonin transporters (SERT), which prevents 5-HT binding and cellular internalization, allowing for accumulation of extracellular 5-HT available to bind to 5-HT(2A) receptor (R). 31711155 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 AlteredExpression disease BEFREE It also provided evidence that 5-HTR2A mRNA levels in PBMCs of MDD patients could be associated with the severity of depression and the duration of the illness. 28125323 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease BEFREE It is proposed that the demonstrated 5-HT1A-5-HT2A isoreceptor complexes may play a role in depression through integration of 5-HT recognition, signaling and trafficking in the plasma membrane in two major 5-HT receptor subtypes known to be involved in depression. 28920103 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease BEFREE Previous studies have identified SLC6A4 and HTR2A associations with SSRI response in patients with depression and 5-HTTLPR (SLC6A4) associations with escitalopram response in ASD. 26262902 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 GeneticVariation disease BEFREE Reports have shown an association of a serotonin-2A receptor (HTR2A) gene T102C polymorphism with AD + P and with depression during AD. 17525976 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 GeneticVariation disease BEFREE SNPs in HTR2A were associated with both pain phenotypes in the discovery cohort, and a number of these SNP associations were replicated in the validation cohort, some of which were attenuated after adjustment for depression. 21305503 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease BEFREE Stress and anxiety disorders are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (CRFR1) and serotonin receptor (5-HT(2)R). 20383137 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease PSYGENET Targeted analysis of HTR2A in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study reveals associations between functional variants and depression severity or citalopram response. 23158458 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 GeneticVariation disease BEFREE Targeted analysis of HTR2A in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study reveals associations between functional variants and depression severity or citalopram response. 23158458 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease BEFREE The HTR2A gene may be involved in the development of depression by influencing the ability of individuals to use environmental support. 17339524 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 Biomarker disease BEFREE The HTR2A gene may be involved in the development of depression by influencing how individuals respond to environmental conditions. 17510953 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.500 GeneticVariation disease BEFREE The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome. 23537781 2013