Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have shown an association of allele C of the 5-HT2A-T102C polymorphism with suicidal ideation in patients with major depression.
|
11121191 |
2000 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
HTR2A-1438A/G polymorphism influences the risk of schizophrenia but not bipolar disorder or major depressive disorder: a meta-analysis.
|
23404241 |
2013 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Converging translational evidence for the involvement of the serotonin 2A receptor gene in major depressive disorder.
|
24801750 |
2014 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Interaction of TPH2 and 5-HT2A Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study.
|
31019472 |
2019 |
Unipolar Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia.
|
14744462 |
2004 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Influence of 5-HTR2A genetic polymorphisms on the efficacy of antidepressants in the treatment of major depressive disorder: a meta-analysis.
|
25108775 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population.
|
19428704 |
2009 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
5-HT2A receptor -1438 G/A polymorphism and serotonergic antidepressant-induced sexual dysfunction in male patients with major depressive disorder: a prospective exploratory study.
|
22612784 |
2012 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The serotonin 2A (5-HT2A) receptor gene has been implicated in the pathogenesis of suicidal behavior by a genetic association between the 5-HT2A C102T silent polymorphism and suicidality in patients with major depression.
|
17221840 |
2007 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia.
|
24962835 |
2014 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Additional evidence for a role of serotonin (5-HT) in the pathogenesis of suicidal behavior is provided by a recent report that the 5-HT2A (HTR2A) T102C polymorphism was associated with suicidality in patients with major depression.
|
15469201 |
2004 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis.
|
25270656 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several studies in major depression have implicated a role of the serotonin receptor gene (HTR2A) in treatment response to antidepressants.
|
22006095 |
2013 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that variation in the 5-HT2A receptor gene may play a role in the development of major depression with seasonal pattern and support the existence of a genetic and etiological heterogeneity underlying the diagnosis of major depression.
|
11317230 |
2001 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
|
19590397 |
2009 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia.
|
24962835 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis.
|
25270656 |
2014 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Neuroimaging, immunologic, and pharmacologic studies have emphasized the role of 5-HT2A and 5-HT3A serotonin receptors in the pathophysiology of major depression.
|
28125323 |
2017 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate the influence of a HTR2A polymorphism on aspects of somatization in major depression, which co-occurs with an unfavorable antidepressant treatment outcome.
|
21838737 |
2011 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.
|
21136126 |
2010 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Overall our results suggest that the investigated 5-HT2A and 5-HTTLPR polymorphisms are not major susceptibility factors in the etiology of major depression.
|
11311507 |
2001 |
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Preclinical and imaging/post-mortem studies in humans provide strong support for the involvement of HTR1A and HTR2A genes in MD.
|
23547754 |
2013 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to determine the relationship between the polymorphisms of -1438A/G and 102T/C in the 5-HT2A receptor (HTR2A) gene and nausea/vomiting as a side effect induced by sertraline (SERT) or citalopram (CIT) in patients with major depressive disorder.
|
30221791 |
2018 |
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results demonstrated that the -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene was unlikely to have a major role in therapeutic response to fluvoxamine in Japanese patients with major depressive disorder.
|
12422060 |
2002 |