|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia.
|
24962835 |
2014 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found that the association of the HTR2A -1438A/G polymorphism with SZ depends on the ethnic origin of the study population, and this genetic variant does not modify the susceptibility to BD or MDD.
|
23404241 |
2013 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The serotonin 2A (5-HT2A) receptor gene has been implicated in the pathogenesis of suicidal behavior by a genetic association between the 5-HT2A C102T silent polymorphism and suicidality in patients with major depression.
|
17221840 |
2007 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine the relationship between the -1438A/G polymorphism in the 5-HTR2A gene and the response to citalopram in a Korean population with major depressive disorder (MDD).
|
16127283 |
2005 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggested that the 5-HTR2A rs6313 T>C polymorphism was significantly correlated with a higher response rate to antidepressants in MDD patients (allele model: OR=1.33, 95% CI=1.05-1.68, P=0.020; dominant model: OR=1.62, 95% CI=1.21-2.18, P=0.001; homozygous model: OR=1.85, 95% CI=1.18-2.90, P=0.008).
|
25108775 |
2014 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, two single nucleotide polymorphisms of the HTR2A gene (rs6314 ie His452Tyr and rs6313 ie rs6313" genes_norm="3356">102C/T), which specific allelic variants may decrease 5-HT2AR-mediated transmission (as in Htr2a(-/-)mice), were studied in a sample of 485 Caucasian patients with MDD.
|
24801750 |
2014 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Additional evidence for a role of serotonin (5-HT) in the pathogenesis of suicidal behavior is provided by a recent report that the 5-HT2A (HTR2A) T102C polymorphism was associated with suicidality in patients with major depression.
|
15469201 |
2004 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results demonstrated that the -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene was unlikely to have a major role in therapeutic response to fluvoxamine in Japanese patients with major depressive disorder.
|
12422060 |
2002 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To explore the possible relationship between six single nucleotide polymorphisms (SNPs) (rs6311 and rs6305 of 5-HT2A, rs5443 of Gβ3, rs2230739 of ACDY9, rs1549870 of PDE1A and rs255163 of CREB1, which are all related with 5-HT2A the signal transduction pathway) and the response efficacy to selective serotonin reuptake inhibitor (SSRI) treatments in major depressive disorder (MDD) Chinese.
|
22480177 |
2012 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.
|
21136126 |
2010 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the HTR2A gene, were studied in 420 patients with MD to investigate the relationship between these genes and suicidal ideation in MD.
|
19897250 |
2009 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
|
19590397 |
2009 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Interaction of TPH2 and 5-HT2A Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study.
|
31019472 |
2019 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:56-60, 2000.
|
10686553 |
2000 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this prospective study was to examine whether the 5-HT2A receptor -1438 G/A polymorphism has functional consequences on sexual well-being in young adult men presenting with their first episode of major depressive disorder (MDD) after serotonergic antidepressant treatment.
|
22612784 |
2012 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to determine the relationship between the polymorphisms of -1438A/G and 102T/C in the 5-HT2A receptor (HTR2A) gene and nausea/vomiting as a side effect induced by sertraline (SERT) or citalopram (CIT) in patients with major depressive disorder.
|
30221791 |
2018 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The 102T/C polymorphism of the 5-HT(2A) receptor gene was analyzed in 159 patients with major depression (DSM-IV criteria) and 164 unrelated and healthy controls using a case control design.
|
11803534 |
2001 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to explore whether the variants in the 5-HT1A and 5-HT2A gene are susceptible to SZ or MDD in the Chinese Han population.
|
27756686 |
2016 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Many studies investigated the association between MDD and BD with the 5-HT2A 102 T/C, the 5-HTT promoter 44 bp insertion/deletion and the intron 2 VNTR polymorphisms, and thus, these could be pooled using meta-analytic techniques.
|
12851635 |
2003 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis.
|
25270656 |
2014 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have shown an association of allele C of the 5-HT2A-T102C polymorphism with suicidal ideation in patients with major depression.
|
11121191 |
2000 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A preliminary association study between serotonin transporter (5-HTTLPR), receptor polymorphisms (5-HTR1A, 5-HTR2A) and depression symptom-clusters in a north Indian population suffering from Major Depressive Disorder (MDD).
|
31228794 |
2019 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interaction between two HTR2A polymorphisms and gender is associated with treatment response in MDD.
|
21741447 |
2011 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Overall our results suggest that the investigated 5-HT2A and 5-HTTLPR polymorphisms are not major susceptibility factors in the etiology of major depression.
|
11311507 |
2001 |